Carbonated Beverages and Chronic Kidney Disease

Saldana, Tina M.; Basso, Olga; Darden, Rebecca; Sandler, Dale P.

doi:10.1097/ede.0b013e3180646338

Cited by 90 publications

(93 citation statements)

References 26 publications

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“…The authors concluded that drinking cola beverages over time likely led to higher levels of phosphoric acid that caused kidney damage via mechanism of nephrocalcinosis. 28 This study was not able to explore the association between sugarsweetened beverages and CKD, as significant associations were seen with both sugar-sweetened colas and artificially sweetened colas, and further comparisons between sweetened versus nonsweetened noncola drinks were not made.…”

Section: Sugar-sweetened Beverages and Kidney Outcomesmentioning

confidence: 97%

“…As with the first prospective study, the exposure of more than one beverage daily in this study is less than the exposure studied in earlier studies that yielded significant results. 28,29 This study also did not provide information on antihypertensive medications that might have been important confounders and that might also have affected serum uric acid level. Bomback and colleagues and other reviewers caution readers to not interpret the "negative" study as dismissing the effects of sugar-sweetened beverages on hyperuricemia and CKD.…”

Section: Us Endocrinologymentioning

confidence: 98%

“…The authors theorized that the damaging effects of fructose may be limited only to incipient kidney disease and no longer be harmful to kidneys that have already suffered chronic insults. 28 Shoham et al 29 Bomback et al 30 Bomback et al 31 Bomback et al 31 Lin et al …”

Section: Sugar-sweetened Beverages and Kidney Outcomesmentioning

confidence: 99%

“…28,29 This study identified the need for studies of larger populations having varying degrees of kidney function.…”

Section: Us Endocrinologymentioning

confidence: 99%

“…This result with artificial sweeteners was not consistent with prior observational studies. 28,29,31 Authors noted that a higher consumption of diet soda may be a marker of unmeasured risk factors that resulted in a higher risk for kidney decline for women consuming artificial sweeteners. 33 Another limitation of this study was the small proportion of participants having high sugar-sweetened beverage consumption (∼3 % of the study population), so a definite association between sugar intake and kidney outcomes could not be established.…”

Section: Us Endocrinologymentioning

confidence: 99%

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Sugar-sweetened Beverages and Chronic Kidney Disease

Wang¹,

Upadhyay²

2015

US Endocrinology

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Increasing consumption of sugar-sweetened beverages has occurred in parallel with the increasing prevalence of chronic kidney disease (CKD) in the US. Consumption of sugar-sweetened beverages, particularly with fructose, has been shown to play an important role in the pathogenesis of obesity, diabetes, hypertension, hyperuricemia, and nephrolithiasis, all of which are risk factors for CKD. However, the direct role of sugarsweetened beverages in the progression of CKD remains unclear. To date, five epidemiologic studies have examined the association between sugar consumption and kidney outcomes, with two showing statistically significant positive associations between higher sugar intake and adverse kidney outcomes. Even though the direct causal relationship between sugar-sweetened beverages and CKD has not been definitely established, it is advisable to counsel individuals with CKD and those at risk for CKD to limit the intake of sugar-sweetened beverages in light of its known detrimental effects on CKD risk factors. KeywordsSugar-sweetened beverages, chronic kidney disease, hyperuricemia -1995 and 1995-1999. 6 During both periods, weight gain was highest among participants who increased their sugar-sweetened beverage consumption from one or fewer drinks per week to one or more drinks per day (4.69 and 4.20 kg for the two periods, respectively) and lowest among participants who decreased their overall sugar-sweetened beverage intake (1.34 and 0.15 kg for the two periods, respectively). Likewise, Palmer and colleagues examined more than 40,000 women in the Black Women's Health Study and found that participants who increased their intake of sugar-sweetened

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Section: Sugar-sweetened Beverages and Kidney Outcomesmentioning

confidence: 97%

Section: Us Endocrinologymentioning

confidence: 98%

Section: Sugar-sweetened Beverages and Kidney Outcomesmentioning

confidence: 99%

“…28,29 This study identified the need for studies of larger populations having varying degrees of kidney function.…”

Section: Us Endocrinologymentioning

confidence: 99%

Section: Us Endocrinologymentioning

confidence: 99%

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Sugar-sweetened Beverages and Chronic Kidney Disease

Wang¹,

Upadhyay²

2015

US Endocrinology

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Sweetened Beverage Intake and Incident Chronic Kidney Disease in the UK Biobank Study

Heo,

Koh,

Park

et al. 2024

JAMA Netw Open

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ImportanceAn increasing body of evidence indicates an association between consuming sugar or its alternatives and cardiometabolic diseases. However, the effects of the consumption of sugar-sweetened beverages, artificially sweetened beverages, and natural juices on kidney health remain unclear.ObjectiveTo investigate the association of the intake of sugar-sweetened beverages, artificially sweetened beverages, and natural juices with the risk of chronic kidney disease (CKD), and the effect of substituting these beverage types for one another on this association.Design, Setting, and ParticipantsThis prospective, population-based cohort study analyzed data from the UK Biobank. Participants without a history of CKD who completed at least 1 dietary questionnaire were included. The follow-up period was from the date of the last dietary questionnaire until October 31, 2022, in England; July 31, 2021, in Scotland; and February 28, 2018, in Wales. Data were analyzed from May 1 to August 1, 2023.ExposuresConsumption of sugar-sweetened beverages, artificially sweetened beverages, and natural juices.Main Outcomes and MeasuresThe primary outcome was incident CKD. Multivariable Cox proportional hazards models were used to estimate the associations between the 3 beverage types and incident CKD. A substitution analysis was used to evaluate the effect on the associations of substituting one beverage type for another.ResultsA total of 127 830 participants (mean [SD] age, 55.2 [8.0] years; 66 180 female [51.8%]) were included in the primary analysis. During a median (IQR) follow-up of 10.5 (10.4-11.2) years, 4459 (3.5%) cases of incident CKD occurred. The consumption of more than 1 serving per day of sugar-sweetened beverages was associated with higher risk of incident CKD (adjusted hazard ratio [AHR], 1.19 [95% CI, 1.05-1.34]) compared with not consuming sugar-sweetened beverages. The AHR for participants consuming more than 0 to 1 serving per day of artificially sweetened beverages was 1.10 (95% CI, 1.01-1.20) and for consuming more than 1 serving per day was 1.26 (95% CI, 1.12-1.43) compared with consuming no artificially sweetened beverages. By contrast, there was no significant association between natural juice intake and incident CKD (eg, for &gt;1 serving per day: HR, 0.99 [95% CI, 0.87-1.11]; P = .10). Substituting sugar-sweetened beverages with artificially sweetened beverages did not show any significant difference in the risk of CKD (HR, 1.03 [95% CI, 0.96-1.10]). Conversely, replacing 1 serving per day of sugar-sweetened beverage with natural juice (HR, 0.93 [95% CI, 0.87-0.97]) or water (HR, 0.93 [95% CI, 0.88-0.99]) or replacing 1 serving per day of artificially sweetened beverage with natural juice (HR, 0.90 [95% CI, 0.84-0.96]) or water (HR, 0.91 [95% CI, 0.86-0.96]) was associated with a reduced risk of incident CKD.Conclusions and RelevanceFindings from this cohort study suggest that lower consumption of sugar-sweetened beverages or artificially sweetened beverages may reduce the risk of developing CKD.

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Occupational exposures and chronic kidney disease: Possible associations with endotoxin and ultrafine particles

Sponholtz

Sandler

Parks

et al. 2015

American J Industrial Med

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Background Chronic kidney disease (CKD) carries a high public health burden yet there is limited research on occupational factors, which are examined in this retrospective case-control study. Methods Newly diagnosed cases of CKD (n=547) and controls (n=508) from North Carolina provided detailed work histories in telephone interviews. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results There was heterogeneity in the association of CKD and agricultural work, with crop production associated with increased risk and work with livestock associated with decreased risk. Work with cutting/cooling/lubricating oils was associated with a reduced risk. CKD risk was increased for working in dusty conditions. Conclusions CKD risk was reduced in subjects with occupational exposures previously reported to involve endotoxin exposure. Further, exposure to dusty conditions was consistently associated with increased risk of glomerulonephritis across industry, suggesting that research on CKD and ultrafine particulates is needed.

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Carbonated Beverages and Chronic Kidney Disease

Abstract: These preliminary results suggest that cola consumption may increase the risk of chronic kidney disease.

Cited by 90 publications

References 26 publications

Sugar-sweetened Beverages and Chronic Kidney Disease

Sugar-sweetened Beverages and Chronic Kidney Disease

Sweetened Beverage Intake and Incident Chronic Kidney Disease in the UK Biobank Study

Occupational exposures and chronic kidney disease: Possible associations with endotoxin and ultrafine particles

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