Carbonyl scavenger and antiatherogenic effects of hydrazine derivatives

Galvani, Sylvain; Coatrieux, Christelle; Elbaz, Meyer; Grazide, Marie-Hélène; Thiers, Jean-Claude; Parini, Angelo; Uchida, Koji; Kamar, Nassim; Rostaing, Lionel; Baltas, Michel; Salvayre, Robert; Nègre‐Salvayre, Anne

doi:10.1016/j.freeradbiomed.2008.08.026

Cited by 97 publications

(81 citation statements)

References 50 publications

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“…The medication with hydralazine (received by daily intraperitoneal injections) was reported to significantly improve behavioral outcomes and lessen myelin damage in spinal cord [96]. Finally, in both rabbit femoral artery smooth muscle cells treated with oxidized LDL and ApoE À/À mice (model for atherosclerosis), the application of hydralazine and its derivatives was reported to block the carbonyl stress through reversing the decrease of free amino group contents and the increase of carbonylated protein levels [97]. All these studies suggest the beneficial effects of hydralazine and its derivatives as ACR scavengers.…”

Section: Impact On Healthmentioning

confidence: 99%

Acrolein scavengers: Reactivity, mechanism and impact on health

Zhu

Sun

Jiang

et al. 2011

Molecular Nutrition Food Res

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Acrolein (ACR) is an α,β-unsaturated aldehyde that exists extensively in the environment and (thermally processed) foods. It can also be generated through endogenous metabolism. Its high electrophilicity makes this aldehyde notorious for its facile reaction with biological nucleophiles, leading to the modification of proteins/DNA and depletion of glutathione. Recent studies also have revealed its roles in disturbing various cell signing pathways in biological systems. With growing evidences of ACR's implication in human diseases, strategies to eliminate its hazardous impacts are of great importance. One of the intervention strategies is the application of reactive scavengers to directly trap ACR. Some known ACR scavengers include sulfur (thiol)-containing and nitrogen (amino)-containing compounds as well as the newly emerging natural polyphenols. In this review, the interactions between ACR and its scavengers are highlighted. The discussion about ACR scavengers is mainly focused on their chemical reactivity, trapping mechanisms as well as their roles extended to biological relevance. In addition to their direct trapping effect on ACR, these scavengers might possess multiple functions and offer additional benefits against ACR-induced toxicity. A comprehensive understanding of the mechanism involved may help to establish ACR scavenging as a novel therapeutic intervention against human diseases that are associated with ACR and/or oxidative stress.

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Section: Impact On Healthmentioning

confidence: 99%

Acrolein scavengers: Reactivity, mechanism and impact on health

Zhu

Sun

Jiang

et al. 2011

Molecular Nutrition Food Res

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“…Aminoguanidine sequesters FA in vitro and in vivo (65), and acrolein and 3-AP have been shown to be sequestered by hydralazine, dihydralazine and PLZ, producing inert hydrazones (8,66). PLZ was also shown to sequester 4-HNE in vitro (67). The free hydrazine group of PLZ interacts with the aldehyde to produce a hydrazone molecule (Figure 2).…”

Section: Phenelzine and Reactive Aldehydesmentioning

confidence: 99%

Phenelzine: An Old Drug That May Hold Clues to The Development of New Neuroprotective Agents

MacKenzie

Song

Dursun

et al. 2010

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…RLS are biologically important, because they modify proteins associated with signal transduction (18,51,90), energy production (21), mitochondrial respiration (33,46), and cell death pathways (36,42,45,89). At low levels, many RLS play a role in cell signaling events (16,25,91,96) and in this case, control the formation of reactive oxygen species (ROS)/reactive nitrogen species (RNS) and have a protective role (5,28,37,101). However, in pathology, the role of RLS changes dramatically.…”

Section: Introductionmentioning

confidence: 99%

The Electrophile Responsive Proteome: Integrating Proteomics and Lipidomics with Cellular Function

Higdon

Landar²,

Barnes³

et al. 2012

Antioxidants & Redox Signaling

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Significance: The process of lipid peroxidation is emerging as an important mechanism that mediates the posttranslational modification of proteins. Through advanced analytical techniques, lipidomics is now emerging as a critical factor in our understanding of the pathology of a broad range of diseases. Recent Advances: During enzymatic or nonenzymatic lipid peroxidation, the simple structure of an unsaturated fatty acid is converted to an oxylipidome, many members of which are electrophilic and form the reactive lipid species (RLS). This aspect of lipid biology is particularly important, as it directly connects lipidomics with proteomics through the posttranslational modification of a sub-proteome in the cell. This arises, because the electrophilic members of the oxylipidome react with proteins at nucleophilic amino-acid residues and so change their structure and function to form electrophile-responsive proteomes (ERP). Critical Issues: Biological systems have relatively few but well-defined and mechanistically distinct pro-oxidant pathways generating RLS. Defining the ERPs and the mechanisms underlying their formation and action has been a major focus for the field of lipidomics and redox signaling. Future Directions: We propose that a unique oxylipidome can be defined for specific oxidants and will predict the biological responses through the reaction with proteins to form a specific ERP. In this review, we will describe the ERPs that modulate antioxidant and anti-inflammatory protective pathways, including the activation of Keap1/Nrf2 and the promotion of cell death through interactions with mitochondria. Antioxid. Redox Signal. 17, 1580-1589.

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Carbonyl scavenger and antiatherogenic effects of hydrazine derivatives

Cited by 97 publications

References 50 publications

Acrolein scavengers: Reactivity, mechanism and impact on health

Acrolein scavengers: Reactivity, mechanism and impact on health

Phenelzine: An Old Drug That May Hold Clues to The Development of New Neuroprotective Agents

The Electrophile Responsive Proteome: Integrating Proteomics and Lipidomics with Cellular Function

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