Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation

Interaction of single and multi wall carbon nanotubes with the biological systems: tau protein and PC12 cells as targets

“…In comparison with control cells, which appeared uniformly stained green in color ( Fig. 11A–C ), apoptotic cells contain bright green and orange condensed bodies in their nuclei representing nuclear DNA fragmentation, and necrotic cells present uniformly orange-stained cell nuclei 41 . Analysis of results obtained in AO/EB dual staining indicated that MWCNT in comparison with SWCNT resulted in activation of necrotic modes of cell death ( Fig.…”

In vivo and in vitro effects of curcumin on head and neck carcinoma: a systematic review

“…This process led to the exclusion of 54 studies (Table S2). At the end, 30 articles were maintained for final analyses . A flowchart detailing this process is depicted in Fig.…”

“…Initiator caspases such as caspase 8 and caspase 9, which cleave inactive pro‐forms of effector caspases, were evaluated in eight included studies. Effector caspase 3 and caspase 7 were evaluated in 12 included studies . The intrinsic or mitochondrial apoptotic pathway is mostly controlled by members of the Bcl‐2 family, which may act as inhibitors or promoters of apoptosis .…”

Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

“…Curcumin induced the expression of HSP70 in HeLa cells, and the mechanism of induction was dependent on activation of HSF1 . Another study in human laryngeal carcinoma cells showed that curcumin induced reactive oxygen species (ROS) formation, which coincided with the induction of lipid and DNA damage as well as induction of apoptosis, and this outcome may have resulted from induced HSP70 expression by curcumin . Mild hyperthermia applied to nanoparticle‐encapsulated curcumin (nCCM), which is responsive to heat, augmented cancer cell destruction in PC‐3 (human prostate adenocarcinoma) cancer cells via induction of apoptosis and necrosis mediated through injury signaling pathways associated with HSP70 and HSP27.…”

“…78 Another study in human laryngeal carcinoma cells showed that curcumin induced reactive oxygen species (ROS) formation, which coincided with the induction of lipid and DNA damage as well as induction of apoptosis, and this outcome may have resulted from induced HSP70 expression by curcumin. 79 Mild hyperthermia applied to nanoparticle-encapsulated curcumin (nCCM), which is responsive to heat, augmented cancer cell destruction in PC-3 (human prostate adenocarcinoma) cancer cells via induction of apoptosis and necrosis mediated through injury signaling pathways associated with HSP70 and HSP27. Improved uptake and retention of nCCM by the cells as a consequence of hyperthermia played a role, causing decreased exocytosis and facilitating the delivery of nCCM to the nucleus.…”