Carbosilandendrimere – Synthese, Funktionalisierung und Anwendung

Schlenk, Christian; Frey, Holger

doi:10.1007/s007060050158

Cited by 3 publications

(4 citation statements)

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“…Carbosilane dendrimers are a type of hyperbranched macromolecules based on CASi bonds which provides them with an hydrophobic internal skeleton. 22 However, these dendrimers can be transformed in water soluble compounds by an accurate functionalization of their surface, for example with ionic groups (cationic or anionic). The presence of a highly functionalized surface in these dendrimers along with a defined structure and inertness have allowed their recent used in medicinal chemistry.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

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Synthesis of anionic carbosilane dendrimers via “click chemistry” and their antiviral properties against HIV

Arnáiz

Vacas-Córdoba

Galán

et al. 2014

J. Polym. Sci. Part A: Polym. Chem.

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The synthesis and characterization of four families of anionic carbosilane dendrimers bearing carboxylate, phosphonate, naphthylsulfonate, and sulfate terminal groups prepared by cycloaddition of azide–alkyne catalyzed by copper (CuAAC) are presented here. For the preparation of these anionic carbosilane dendrimers, two strategies starting from azide‐terminated carbosilane dendrimers were followed: (i) click coupling of neutral alkynes followed by derivatization into anionic moieties or (ii) click coupling of anionic alkynes. Both strategies require different reaction conditions in order to accommodate the different substrate polarities. These anionic dendrimers, in general, do not present cell toxicity in vitro until concentration up to 20 µM. Therefore, they can be used in inhibition experiments in concentrations below this limit. We have observed that dendrimers bearing phosphonate groups possess poor anti‐HIV capabilities in vitro in PBMCs, while carboxylate dendrimers can reduce HIV infection levels moderately. On the other hand, sulfate and naphthylsulfonate dendrimers are powerful anti‐HIV agents and their antiviral activity is generation and concentration dependent. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 1099–1112

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Section: Synthesis and Characterizationmentioning

confidence: 99%

“…Carbosilane dendrimers are a type of hyperbranched macromolecules based on CSi bonds which provides them with an hydrophobic internal skeleton . However, these dendrimers can be transformed in water soluble compounds by an accurate functionalization of their surface, for example with ionic groups (cationic or anionic).…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Synthesis of anionic carbosilane dendrimers via “click chemistry” and their antiviral properties against HIV

Arnáiz

Vacas-Córdoba

Galán

et al. 2014

J. Polym. Sci. Part A: Polym. Chem.

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“…Adsorption mechanism states that two phases are connected by chemical bonds, or an organic adhesion promoter layer is normally introduced to the interface. The organic adhesion promoter layer with two reactive groups can act with two phases to improve adhesion strength [9][10][11] . As reported, the silane coupling agent was introduced to improve the durability of aluminum bonded to the epoxy resin [12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Dependence of Amino-functionalization on Interfacial Adhesion Strength in Epoxy/Al Laminated Composites

Guo

Peng

et al. 2012

Polymers and Polymer Composites

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In epoxy/Al laminated composites, the interface between polymers and metals plays the role of load transfer from epoxy to Al. However, the interfacial bonding between epoxy and aluminum tends to be weak. In this paper, in order to improve the interfacial strength the dendrimer layer—poly (amido amine) (PAMAM) was used to realize the amino functionalization of the interface of epoxy/Al laminated composites. The amino functionalization was tuned by controlling the hydroxyl group concentration through different Al surface treatments. The results show the interfacial adhesion strength between aluminum and epoxy was highly dependent of amino group content. The adhesion strength of epoxy/Al interface is increased by 50% after PAMAM layer was introduced into the NaOH-treated interface between epoxy and Al surface.

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“…Polycarbosilanes are a class of hybrid polymers having regular carbon block‐spaced silicon backbone structures, [C m Si] n , which have found their applications in silicarbide ceramics,1, 2 surfactants,3 and catalysis support 4. The synthesis of these polymers varies depending on the number of carbon atoms ( m ) inserted between two silicon atoms.…”

Section: Introductionmentioning

confidence: 99%

Mechanism and characterization of alkylene‐ and p‐ethylenebenzylene‐spaced polycarbosilanes ceramic precursor synthesized by electropolymerization

Cabasso

Yuan

Wang

2008

J. Polym. Sci. A Polym. Chem.

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An electropolymerization of haloalkylhalosilanes (ClRSiCH3Cl2) that possess two types of electroactive sites, that is, the CCl and SiCl bond is described. The one‐pot synthesis method is shown to yield branched polycarbosilanes having a regular carbon block‐spaced silicon backbone structure. A series of branched polycarbosilanes, [RSiCH3]n with R being CH2, C2H4, C3H6, and CH2C6H4C2H4, have been successfully electropolymerized with Mn up to 42,600 Dalton. Experimental and simulation cyclic voltammetry of these monomers and the computational examination of their LUMOs are applied to study the electropolymerization mechanism. The results suggest that polymerization proceeds by iterating steps involving (1) electroreduction of a CCl bond to a carbanion, which is catalyzed by silylanion radical [Cl SiCl(CH3)RCl] and/or Ni(0)/TDA‐1; and (2) nucleophilic attack of carbanions to SiCl bonds of a second monomer or oligomer to extend the polymer chain. The investigation reveals that the R spacer has a considerable impact on the polymerizability of the corresponding monomer. Such interfacial polymerization resembles a template polymerization, leading to unique microstructures that were preserved even after converted to silicon carbide ceramics at high temperatures. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 7677–7689, 2008

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Carbosilandendrimere – Synthese, Funktionalisierung und Anwendung

Cited by 3 publications

References 0 publications

Synthesis of anionic carbosilane dendrimers via “click chemistry” and their antiviral properties against HIV

Synthesis of anionic carbosilane dendrimers via “click chemistry” and their antiviral properties against HIV

Dependence of Amino-functionalization on Interfacial Adhesion Strength in Epoxy/Al Laminated Composites

Mechanism and characterization of alkylene‐ and p‐ethylenebenzylene‐spaced polycarbosilanes ceramic precursor synthesized by electropolymerization

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