Carboxymethyl chitosan/ionic liquid imidazolium-based nanoparticles as nanocarriers for zinc phthalocyanine and its photodynamic activity

Ebani, Patrícia Regina; Stefanello, Luiza Bertoldo; Kuhn, Bruna L.; Frizzo, Clarissa P.; Burgo, Thiago A. L.; Kloster, Carmen Luisa; Villetti, Marcos A.

doi:10.1016/j.molliq.2021.116874

Cited by 13 publications

(2 citation statements)

References 56 publications

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“…Zinc Phthalocyanine(ZnPc)-loaded carboxymethyl chitosan/ionic liquid imidazolium-based nanoparticles in an in vitro release study confirmed the sustained release of ZnPc. The synthesized nanoparticles showed great ability to generate singlet oxygen, and it is appropriate to facilitate the high PDT activity to diseased cells [41]. Light-responsive polymers have attracted considerable attention in PDT, and are designed to load and release the encapsulated drugs inside the cells.…”

Section: Polymer-based Nanocarriersmentioning

confidence: 99%

Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Kumar

Abrahamse

2021

Pharmaceutics

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In recent years, the role of nanotechnology in drug delivery has become increasingly important, and this field of research holds many potential benefits for cancer treatment, particularly, in achieving cancer cell targeting and reducing the side effects of anticancer drugs. Biocompatible and biodegradable properties have been essential for using a novel material as a carrier molecule in drug delivery applications. Biocompatible nanocarriers are easy to synthesize, and their surface chemistry often enables them to load different types of photosensitizers (PS) to use targeted photodynamic therapy (PDT) for cancer treatment. This review article explores recent studies on the use of different biocompatible nanocarriers, their potential applications in PDT, including PS-loaded biocompatible nanocarriers, and the effective targeting therapy of PS-loaded biocompatible nanocarriers in PDT for cancer treatment. Furthermore, the review briefly recaps the global clinical trials of PDT and its applications in cancer treatment.

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Section: Polymer-based Nanocarriersmentioning

confidence: 99%

Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Kumar

Abrahamse

2021

Pharmaceutics

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“…The experiments were carried out in triplicate (n = 3) and the results are presented as the percentage (%) of drug released as a function of time. To evaluate the drug release profile from NP-11, the data were fitted using six kinetic models, including zero order, first order, biexponential, Higuchi, Korsmeyer-Peppas, and Hixon Crowell [46,52,53].…”

Section: In Vitro Release Kineticsmentioning

confidence: 99%

Design and Characterization of Maltoheptaose-b-Polystyrene Nanoparticles, as a Potential New Nanocarrier for Oral Delivery of Tamoxifen

et al. 2021

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Tamoxifen citrate (TMC), a non-steroidal antiestrogen drug used for the treatment of breast cancer, was loaded in a block copolymer of maltoheptaose-b-polystyrene (MH-b-PS) nanoparticles, a potential drug delivery system to optimize oral chemotherapy. The nanoparticles were obtained from self-assembly of MH-b-PS using the standard and reverse nanoprecipitation methods. The MH-b-PS@TMC nanoparticles were characterized by their physicochemical properties, morphology, drug loading and encapsulation efficiency, and release kinetic profile in simulated intestinal fluid (pH 7.4). Finally, their cytotoxicity towards the human breast carcinoma MCF-7 cell line was assessed. The standard nanoprecipitation method proved to be more efficient than reverse nanoprecipitation to produce nanoparticles with small size and narrow particle size distribution. Moreover, tamoxifen-loaded nanoparticles displayed spherical morphology, a positive zeta potential and high drug content (238.6 ± 6.8 µg mL−1) and encapsulation efficiency (80.9 ± 0.4 %). In vitro drug release kinetics showed a burst release at early time points, followed by a sustained release profile controlled by diffusion. MH-b-PS@TMC nanoparticles showed higher cytotoxicity towards MCF-7 cells than free tamoxifen citrate, confirming their effectiveness as a delivery system for administration of lipophilic anticancer drugs.

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Recent advances in surface-active ionic liquid-assisted self-assembly systems for drug delivery

Moshikur

Ali

Moniruzzaman

et al. 2021

Current Opinion in Colloid & Interface Science

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Carboxymethyl chitosan/ionic liquid imidazolium-based nanoparticles as nanocarriers for zinc phthalocyanine and its photodynamic activity

Cited by 13 publications

References 56 publications

Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Design and Characterization of Maltoheptaose-b-Polystyrene Nanoparticles, as a Potential New Nanocarrier for Oral Delivery of Tamoxifen

Recent advances in surface-active ionic liquid-assisted self-assembly systems for drug delivery

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