Carboxymethyl pachymaran attenuates short-term stress induced depressive behaviours and over-expression of occludin and claudin-2 in the blood–brain-barrier by regulating inflammatory cytokines- JNK/ERK/p38 pathway

Jia-tao, HE; Hu, Lianhua; Deng, Qi; Sun, Lijun; Zhao, Yun-Tao; Fang, Zhijia; Wang, Chen; Zhao, Jun

doi:10.1016/j.jff.2023.105490

Cited by 3 publications

(2 citation statements)

References 18 publications

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“… Myocardial protection. [ [189] , [190] , [191] ] Ophiopogon japonicus polysaccharide Ophiopogon japonicus SOD, GSH-Px and MDA. Oxidative stress.…”

Section: The Representative Natural Products With Anti-heart Failure ...mentioning

confidence: 99%

“…Traditional Chinese medicine poria peel has diuretic effect, which make it be a classic diuretic in Asian traditional medicine. In recent years, it has been found that pachymaran is the main natural active ingredient for its diuretic and cardiovascular protective effects [ 189 ]. After treatment of pachymaran, the urine output of HF rats is significantly increased, and the plasma BNP level is significantly decreased.…”

Section: The Representative Natural Products With Anti-heart Failure ...mentioning

confidence: 99%

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The recent advance and prospect of natural source compounds for the treatment of heart failure

Chen,

Liu,

et al. 2024

Heliyon

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“… Myocardial protection. [ [189] , [190] , [191] ] Ophiopogon japonicus polysaccharide Ophiopogon japonicus SOD, GSH-Px and MDA. Oxidative stress.…”

Section: The Representative Natural Products With Anti-heart Failure ...mentioning

confidence: 99%

Section: The Representative Natural Products With Anti-heart Failure ...mentioning

confidence: 99%

The recent advance and prospect of natural source compounds for the treatment of heart failure

Chen,

Liu,

et al. 2024

Heliyon

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Ziziphus Jujube Polysaccharides inhibit over-abundance of fecal butyric acid in mildly stressed growing mice to ameliorate depression-like behavior

Sun,

Luo,

et al. 2024

Food Bioscience

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Gut-Microbiota-Derived Butyric Acid Overload Contributes to Ileal Mucosal Barrier Damage in Late Phase of Chronic Unpredictable Mild Stress Mice

Wang,

Qiu,

Wang

et al. 2024

IJMS

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Intestinal mucosal barrier damage is regarded as the critical factor through which chronic unpredictable mild stress (CUMS) leads to a variety of physical and mental health problems. However, the exact mechanism by which CUMS induces intestinal mucosal barrier damage is unclear. In this study, 14, 28, and 42 d CUMS model mice were established. The indicators related to ileal mucosal barrier damage (IMBD), the composition of the ileal microbiota and its amino acid (AA) and short-chain fatty acid (SCFA) metabolic functions, and free amino acid (FAA) and SCFA levels in the ileal lumen were measured before and after each stress period. The correlations between them are analyzed to investigate how CUMS induces intestinal mucosal barrier damage in male C57BL/6 mice. With the progression of CUMS, butyric acid (BA) levels decreased (14 and 28 d) and then increased (42 d), and IMBD progressively increased. In the late CUMS stage (42 d), the degree of IMBD is most severe and positively correlated with significantly increased BA levels (p < 0.05) in the ileal lumen and negatively correlated with significantly decreased FAAs, such as aspartic, glutamic, alanine, and glycine levels (p < 0.05). In the ileal lumen, the abundance of BA-producing bacteria (Muribaculaceae, Ruminococcus, and Butyricicoccus) and the gene abundance of specific AA degradation and BA production pathways and their related enzymes are significantly increased (p < 0.05). In addition, there is a significant decrease (p < 0.05) in the abundance of core bacteria (Prevotella, Lactobacillus, Turicibacter, Blautia, and Barnesiella) that rely on these specific AAs for growth and/or are sensitive to BA. These changes, in turn, promote further colonization of BA-producing bacteria, exacerbating the over-accumulation of BA in the ileal lumen. These results were validated by ileal microbiota in vitro culture experiments. In summary, in the late CUMS stages, IMBD is related to an excessive accumulation of BA caused by dysbiosis of the ileal microbiota and its overactive AA degradation.

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Carboxymethyl pachymaran attenuates short-term stress induced depressive behaviours and over-expression of occludin and claudin-2 in the blood–brain-barrier by regulating inflammatory cytokines- JNK/ERK/p38 pathway

Cited by 3 publications

References 18 publications

The recent advance and prospect of natural source compounds for the treatment of heart failure

The recent advance and prospect of natural source compounds for the treatment of heart failure

Ziziphus Jujube Polysaccharides inhibit over-abundance of fecal butyric acid in mildly stressed growing mice to ameliorate depression-like behavior

Gut-Microbiota-Derived Butyric Acid Overload Contributes to Ileal Mucosal Barrier Damage in Late Phase of Chronic Unpredictable Mild Stress Mice

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