Carboxymethyl starch-chitosan-coated iron oxide magnetic nanoparticles for controlled delivery of isoniazid

Hussain, Abul; Ramteke, Anand; Sharma, Hemanta Kumar; Maji, Tarun K.

doi:10.3109/02652048.2014.940015

Cited by 40 publications

(18 citation statements)

References 28 publications

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“…The introduction of carboxymethyl groups interrupts the ordered structure of starch. The use of polyelectrolyte complex of carboxymethyl starch and cationic chitosan as coating material on magnetic iron particles was reported in our earlier communication [15]. However, the particle size of the polyelectrolyte complex obtained was in the higher range.…”

Section: Introductionmentioning

confidence: 88%

Carboxymethyl starch-coated iron oxide magnetic nanoparticles: a potential drug delivery system for isoniazid

et al. 2015

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Section: Introductionmentioning

confidence: 88%

Carboxymethyl starch-coated iron oxide magnetic nanoparticles: a potential drug delivery system for isoniazid

et al. 2015

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“…However, this polymer shows some limitations as a coating material, due to the partial protonation of its amino groups in water at physiological pH, which reduces chitosan solubility. Chemical changes in chitosan can overcome these problems, making chitosan derivatives more water-soluble [84,85].…”

Section: Drug Deliverymentioning

confidence: 99%

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

Bruschi

Toledo

2019

Magnetochemistry

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Advances of nanotechnology led to the development of nanoparticulate systems with many advantages due to their unique physicochemical properties. The use of iron-oxide magnetic nanoparticles (IOMNPs) in pharmaceutical areas increased in the last few decades. This article reviews the conceptual information about iron oxides, magnetic nanoparticles, methods of IOMNP synthesis, properties useful for pharmaceutical applications, advantages and disadvantages, strategies for nanoparticle assemblies, and uses in the production of drug delivery, hyperthermia, theranostics, photodynamic therapy, and as an antimicrobial. The encapsulation, coating, or dispersion of IOMNPs with biocompatible material(s) can avoid the aggregation, biodegradation, and alterations from the original state and also enable entrapping the bioactive agent on the particle via adsorption or covalent attachment. IOMNPs show great potential for target drug delivery, improving the therapy as a consequence of a higher drug effect using lower concentrations, thus reducing side effects and toxicity. Different methodologies allow IOMNP synthesis, resulting in different structures, sizes, dispersions, and surface modifications. These advantages support their utilization in pharmaceutical applications, and getting suitable drug release control on the target tissues could be beneficial in several clinical situations, such as infections, inflammations, and cancer. However, more toxicological clinical investigations about IOMNPs are necessary.

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“…The stomach and intestinal sections were cut and opened longitudinally, thus exposing the inner mucosal surface; using a spatula, all of the nanoparticles that were located in each part of the mucosa were collected. [51] The mixture was crushed using a homogenizer to extract vildagliptin-metformin hydrochloride, and the extract was kept for 12 hours. After centrifugation at 1,000×g for 30 minutes, the supernatant was determined spectroscopically.…”

Section: In Vivo Animal Modelmentioning

confidence: 99%

In Vitro and In Vivo Evaluation of Nanoparticles Prepared by Nano Spray Drying for Stomach Mucoadhesive Drug Delivery

Harsha

2014

Drying Technology

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According to a World Health Organization report published in 2010, 346 million people worldwide have diabetes; in Saudi Arabia, 16.8% of the population has been diagnosed with type 2 disease. Many patients with type 2 diabetes are unable to maintain adequate glycemic control even after receiving recent anti-diabetic drugs. Combination vildagliptin and metformin hydrochloride tablets are available; however, both conventional drugs have a short half-life. The formulation of mucoadhesive nanoparticles for these classes of drugs can be most beneficial, as they release the drug slowly into the gastrointestinal tract and maintain the therapeutic drug concentration. Vildagliptin and metformin hydrochloride were prepared with carbopol (VMCN) using a Buchi Nano Spray Drier B-90. The surface morphology was found to be shriveled (due to surface folding), and the average particle size was 437 nm. The percentage drug yield for vildagliptin and metformin hydrochloride in the nanoparticles was 71%±0.5% and 74%±0.3%, respectively, while the drug content was 84%±0.4% and 89%±0.4%, respectively. Ex vivo studies of mucoadhesion were 6.9±0.3 hours. The percentage of swelling was recorded as 162%±4%. In vivo studies of nanoparticles containing vildagliptin and Downloaded by [Selcuk Universitesi] at 08:11 27 December 2014 2 metformin hydrochloride showed that these values were 3.9% and 4.1% at 12 hours respectively.

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Carboxymethyl starch-chitosan-coated iron oxide magnetic nanoparticles for controlled delivery of isoniazid

Abstract: This study revealed that the MMT incorporated PEC of CMS-CS can be effectively used for coating of iron oxide nanoparticles.

Cited by 40 publications

References 28 publications

Carboxymethyl starch-coated iron oxide magnetic nanoparticles: a potential drug delivery system for isoniazid

Carboxymethyl starch-coated iron oxide magnetic nanoparticles: a potential drug delivery system for isoniazid

Pharmaceutical Applications of Iron-Oxide Magnetic Nanoparticles

In Vitro and In Vivo Evaluation of Nanoparticles Prepared by Nano Spray Drying for Stomach Mucoadhesive Drug Delivery

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