Carboxymethyl‐β‐cyclodextrin and histidine‐zeolitic imidazolate framework‐8 used for enantioseparation of three basic drugs in open‐tubular capillary electrochromatography

Miao, Pandeng; Gan, Jie; Zhang, Jian; Ma, Mingxuan; Li, Xiaoqi; Du, Yingxiang; Feng, Zijie; Zhang, Liu

doi:10.1002/chir.23480

Cited by 9 publications

(1 citation statement)

References 38 publications

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“…Capillary chromatographic columns play a central role in capillary HPLC. There are three types of capillary chromatographic columns based on the preparation method of the stationary phase: open tubular columns [14,15], packed columns [16,17], and monolithic columns [18,19]. In comparison to the other two, monolithic capillary columns (MCCs) offer the advantages of high column efficiency and substantial column capacity without requiring the sintering of the frits.…”

Section: Introductionmentioning

confidence: 99%

Study of the Enantioselectivity and Recognition Mechanism of Allyl‐β‐CD Modified Organic Polymer Monolithic Capillary Column

Jia,

Li,

et al. 2024

Chirality

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Allyl‐β‐CD was synthesized and used as the chiral functional monomer to prepare chiral organic polymer monolithic columns in capillary HPLC. First, the enantioselectivity of the prepared allyl‐β‐CD modified organic polymer monolithic capillary columns was investigated. Then, the influences of enantioseparation conditions of chiral drugs were further explored. Finally, the recognition mechanism was studied by molecular docking with AutoDock. Complete enantioseparations of four chiral drugs as well as partial enantioseparations of eight chiral drugs have been achieved. Results showed that the RSD values for run‐to‐run, day‐to‐day, and column‐to‐column variations ranged from 1.2% to 4.6%, 1.4% to 4.7%, and 2.0% to 6.1%, respectively. The enantioselectivity factor rather than resolution is correlated with the binding free energy difference between enantiomers with allyl‐β‐CD. Furthermore, the abundant ether bonds, hydroxyl groups, and hydrophobic cavities in cyclodextrin are responsible for the enantioseparation ability of the chiral monolithic capillary columns.

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