Carboxymethylcellulose Binds to Human Corneal Epithelial Cells and Is a Modulator of Corneal Epithelial Wound Healing

Abstract

CMC probably binds to HCECs through interaction of its glucopyranose subunits with glucose transporters. CMC binding to the matrix proteins stimulated HCEC attachment, migration, and re-epithelialization of corneal wounds.

Activation of the epidermal growth factor receptor by hydrogels in artificial tears

“…The corneal epithelium contains numerous growth factor signaling systems that impact on cell motility (Klenkler and Sheardown, 2004;Wilson et al, 2003), so it is possible that the hydrogels have effects on other receptors. In addition, carboxymethyl cellulose binds to the extracellular matrix and enhances adhesion of corneal epithelial cells, so an effect on the matrix could also contribute to increased cell motility and wound healing (Garrett et al, 2007).…”

“…A key to success is to apply constant stimulation either by frequent applications or using some continuous release device (Brown et al, 1988;Hori et al, 2007;Sheardown et al, 1993) Soluble hydrogels may reside on the cell surface for hours (Garrett et al, 2007;Lee et al, 2000;Peppas and Sahlin, 1996;Salamat-Miller et al, 2005;Sudhakar et al, 2006), and even more prolonged contact may be achieved when applied with continuous release devices. Hydrogels are considered safe (Fu et al, 2005), and our studies suggest that particularly hydroxypropylmethyl cellulose and methyl cellulose may be used to promote wound healing.…”

“…The hydrogel components are typically listed as the "active" ingredients, and they are thought to act by providing viscosity, increased oncotic pressure, and possibly some illdefined demulcent action. A few reports have indicated that hydrogels, such as methyl cellulose and carboxymethyl cellulose, enhance healing of wounds in the cornea (Garrett et al, 2007;Gaton et al, 1998;Lin and Boehnke, 1999).…”

Tempo de reepitelização corneana com a instilação de colírio contendo hialuronato de sódio e carboximetilcelulose

“…Existem vários colírios com essa finalidade, entretanto dois deles chamam atenção pelas suas características farmacêuticas. Os colírios a base de hialu ronato de sódio (HS) e colírios contendo carboximetilcelulose (CMC).A comparação entre as duas substâncias tem fundamento bio químico por terem muitas propriedades semelhantes como a carga iônica, alta microviscosidade e a capacidade de permanecer sobre o epitélio corneano por tempo prolongado (7) . E também por estarem envolvidas na recuperação tecidual.…”

“…A comparação entre as duas substâncias tem fundamento bio químico por terem muitas propriedades semelhantes como a carga iônica, alta microviscosidade e a capacidade de permanecer sobre o epitélio corneano por tempo prolongado (7) . E também por estarem envolvidas na recuperação tecidual.…”