Carboxytherapy for treatment of localized chronic plaque psoriasis: Clinical and histopathologic evaluation

Kamel, Abeer M; Abdelghani, Rania

doi:10.1111/jocd.12494

Cited by 9 publications

(18 citation statements)

References 25 publications

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“…Clinical assessment was done using the total sign score (TSS), also known as psoriasis severity index, which is the summation of erythema, induration, and scale points and ranges between 0 and 12, where each point was given a grade (0 none, 1 mild, 2 moderate, 3 severe, and 4 very severe). 13 The response to treatment was graded as follow.…”

Section: The Outcome Was Assessed Based Onmentioning

confidence: 99%

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Botulinum toxin type‐A versus 5‐fluorouracil in the treatment of plaque psoriasis: Comparative study

Khattab

Samir

2021

J of Cosmetic Dermatology

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Psoriasis is a chronic, inflammatory systemic disease that is characterized by erythematous, scaly patches, or plaques over the skin that occurs due to the hyperproliferation of epidermal keratinocytes. 1,2 The 5-FU is an antimetabolite that inhibits deoxyribonucleic acid synthesis, as well as ribonucleic acid processing and therefore, decreases epidermal proliferation. 3,4 It has been widely used topically, intravenously, 5 and intralesionally in various concentrations (0.5%, 1%, and 5%) in various dermatological 6 and non-dermatological diseases. 7,8 The role of neurocutaneous pathways in the pathogenesis of psoriasis has been suggested based on some reports of improvement of plaque psoriasis after injuries that compromised some branches of the peripheral nervous system. 9,10 BTX injections have been reported for the treatment of numerous dermatological conditions, such as Keloids, hidradenitis suppurativa, and folds dermatitis. 11 The advantage of intralesional is that it allows higher drug concentration in the lesion for a longer duration in comparison with topical treatment while avoiding the systemic adverse effects of these toxic drugs. 12 To study the efficacy and safety of BTX and intralesional 5-fluorouracil in patients with mild-to-moderate chronic plaque psoriasis and to access clinical improvement based on clinical photographs.

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Section: The Outcome Was Assessed Based Onmentioning

confidence: 99%

“…The recurrence area was rated on a 10-point scale at 2 months after treatment in contrast to the baseline lesion: grade 0 (no recurrence), grade 1 (1-10%), grade 2 (11-20%), grade 3 (21-30%), grade 4 (31-40%), grade 5 (41-50%), grade 6 (51-60%), grade 7 (61-70%), grade 8 (71-80%), and grade 9 (81-100%). 13…”

Section: Psoriasis Disability Indexmentioning

confidence: 99%

Botulinum toxin type‐A versus 5‐fluorouracil in the treatment of plaque psoriasis: Comparative study

Khattab

Samir

2021

J of Cosmetic Dermatology

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“…Rejuvenating properties, improvement of tissue oxygenation and increase in venous and lymphatic circulation justify wide usage of carboxytherapy in medicine [6,7]. Various indications for carboxytherapy also make it is an increasingly popular method in aesthetic medicine [8].…”

Section: Indications For the Procedures And Results Of Clinical Trialsmentioning

confidence: 99%

“…Właściwości odmładzające, poprawa utlenowania tkanek oraz nasilenie krążenia żylnego i limfatycznego uzasadniają szerokie zastosowanie karboksyterapii w medycynie [6,7]. Dzięki szerokiemu zakresowi wskazań karboksyterapia zyskuje coraz większe znaczenie w medycynie estetycznej [8].…”

Section: Wskazania Do Zabiegu I Wyniki Badań Klinicznychunclassified

Carboxytherapy in the light of the latest reports. Erythema multiforme-like eruption as a side effect of carboxytherapy

Barańska‐Rybak¹,

Mehrholz²

2019

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Carboxytherapy is a very popular method applied in aesthetic medicine. The procedure is used for the reduction of cellulite, atrophic scarring and stretch marks, treatment of localized adiposities, wrinkle correction and rejuvenation of the skin. It is claimed that carbon dioxide therapy is a very safe procedure with only a small number of complications. Pain, oedema and bruising of the injection area are often side effects of carboxytherapy. There are only a few reports of more serious complications such as subcutaneous emphysema or Mycobacterium infection. The following is the first case report of herpes-associated erythema multiforme caused by carboxytherapy. A 41-year-old woman consulted a dermatologist because of erythematous skin lesions with brightening in the central part of the macules which appeared three days after the carboxytherapy. In the anamnesis recurrent herpes labialis was noted. streszczenie Karboksyterapia jest bardzo popularnym zabiegiem wykorzystywanym w medycynie estetycznej: w redukcji cellulitu, blizn zanikowych i rozstępów, a także w leczeniu miejscowych otłuszczeń, korekcji zmarszczek i odnowie skóry. Uważa się, że jest to bardzo bezpieczny zabieg obarczony małą liczbą powikłań. Do częstych działań ubocznych karboksyterapii należą: ból, obrzęk i zasinienia w miejscu iniekcji. Znane są tylko pojedyncze doniesienia dotyczące bardziej poważnych powikłań, takich jak odma podskórna lub zakażenie prątkami niegruźliczymi. Przedstawiamy pierwszy przypadek rumienia wielopostaciowego wywołanego infekcją wirusem opryszczki będącą powikłaniem karboksyterapii. Pacjentka w wieku 41 lat zgłosiła się do gabinetu dermatologicznego z powodu zmian rumieniowych z przejaśnieniem w centralnej części wykwitów, które pojawiły się 3 dni po karboksyterapii. W wywiadzie odnotowano nawracającą opryszczkę wargową.

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“…It is assumed that carboxytherapy can inhibit production of inflammatory cytokines through inhibition of nuclear factor of activated T‐cells‐kappa β (NFAT‐ƙβ) pathway. On the other hand, carboxytherapy has immunomodulatory effects by inhibition of cytotoxic T cells through activation of T regulatory cells and induction of apoptosis of cytotoxic T cells 5–12 . Therefore, combination of carboxytherapy with NB‐UVB can have synergistic effects and augments anti‐inflammatory effects of NB‐UVB, and accelerates proliferation and migration of melanocytes from hair follicles and periphery of depigmented skin 5–12 …”

Section: Discussionmentioning

confidence: 99%

Combination of carboxytherapy with narrowband‐ultraviolet B in the treatment of recalcitrant areas of vitiligo: A randomized clinical trial

Farajzadeh

Yazdanpanah

Khalili

et al. 2021

Dermatologic Therapy

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Carboxytherapy has been used in the treatment of autoimmune skin diseases such as psoriasis and morphea. Carboxytherapy has antioxidant effects, and leads to better tissue oxygenation, and release of growth factors. In this article, we decided to evaluate efficacy of combined carboxytherapy and narrowband‐ultraviolet B (NB‐UVB) compared to NB‐UVB alone in the treatment of vitiligo. This is a prospective, split‐body double‐blind comparative study performed in patients with generalized stable vitiligo in acral areas and extremities referred to dermatology clinic of Afzalipour hospital in Kerman University of Medical Sciences. NB‐UVB was performed three times a week in non‐consecutive days for 4 months. In each patient, one lesion was randomly treated with carboxytherapy (weekly sessions for total of 16 sessions). Efficacy of treatment was evaluated by percentage of repigmentation of the lesions. Chi‐square test and analysis of variance test (ANOVA) were used to compare efficacy of treatment based on demographic features of the patients and clinical features of the lesions, respectively. Twenty‐eight patients with mean age of 32.35 ± 7.37 years old completed the study. At the end of the treatment, 37% of the patients in combination therapy group demonstrated more than 75% improvement compared to 0% in the monotherapy group (p = 0.001). There was no significant difference between either demographic features of the patients (age, sex, and skin phototypes) or duration of disease with efficacy of the treatment in both groups. Combination of carboxytherapy with NB‐UVB leads to higher percentage of repigmentation and patients' satisfaction compared to monotherapy with NB‐UVB.

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Carboxytherapy for treatment of localized chronic plaque psoriasis: Clinical and histopathologic evaluation

Cited by 9 publications

References 25 publications

Botulinum toxin type‐A versus 5‐fluorouracil in the treatment of plaque psoriasis: Comparative study

Botulinum toxin type‐A versus 5‐fluorouracil in the treatment of plaque psoriasis: Comparative study

Carboxytherapy in the light of the latest reports. Erythema multiforme-like eruption as a side effect of carboxytherapy

Combination of carboxytherapy with narrowband‐ultraviolet B in the treatment of recalcitrant areas of vitiligo: A randomized clinical trial

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