Carcino-sarcoma of the urinary bladder with cartilaginous differentiation: About a case report

Dali, Kheireddine Mrad; Kacem, Aziz; Rhouma, Sami Ben; Chaker, Kays; Sellami, Ahmed; Nouira, Yassine

doi:10.1016/j.eucr.2019.101053

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Nazemi et al also evaluated the clinicopathological features of patients with BCS and found that patients tended to be older men who presented with advanced stage and higher grade 13 . These results are similar to our findings 6–9,14–19 . Further, Nazemi et al showed that most patients (95.9%) underwent cancer‐directed surgery, whereas only a small proportion of patients received radiation (16.7%) 13 .…”

Section: Discussionsupporting

confidence: 88%

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Carcinosarcoma is an aggressive subtype of bladder cancer: A population‐based study

2022

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Background Case reports of bladder carcinosarcoma (BCS) indicate high rates of recurrence and metastasis and poor prognosis. However, the differences in clinicopathologic characteristics and prognosis between BCS and conventional bladder cancer histologies (transitional cell carcinoma [TCC], squamous cell carcinoma [SCC] and adenocarcinoma [AC]) have not been fully clarified in a large study. Therefore, we conducted a large population‐based study to further investigate these differences. Patients and methods Information on patients with BCS and conventional bladder cancer (TCC, SCC or AC) was extracted from the Surveillance, Epidemiology, and End Results database. Categorical variables were compared using Pearson's chi‐squared test or Fisher's exact test. Survival analysis was carried out using the Kaplan–Meier method, and differences in survival were assessed using the log‐rank test. Propensity score matching analysis was conducted to calibrate the differences between the baseline characteristics, after which Cox regression analysis was applied to calculate the hazard ratios and 95% confidence intervals of BCS compared to other subtypes. Subgroup analysis and related interaction were tested to evaluate the consistency and heterogeneity of results. Results We enrolled 152 patients with BCS and 180,196 patients with TCC, SCC or AC. Our results showed that BCS was associated with poor differentiation, advanced stage and an unfavourable overall survival and cancer‐specific survival. BCS had a worse prognosis than TCC and AC, but no statistically significant difference in survival was noted between BCS and SCC. Conclusions BCS is a more aggressive bladder cancer than TCC and AC but is comparable to SCC. These findings broaden our understanding of BCS and may be helpful in clinical practice.

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Section: Discussionsupporting

confidence: 88%

“…13 These results are similar to our findings. [6][7][8][9][14][15][16][17][18][19] Further, Nazemi et al showed that most patients (95.9%) underwent cancer-directed surgery, whereas only a small proportion of patients received radiation (16.7%). 13 We observed similar characteristics in our cohort.…”

Section: Subgroup Analysismentioning

confidence: 99%

Carcinosarcoma is an aggressive subtype of bladder cancer: A population‐based study

2022

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OUP accepted manuscript

Rahoui

2022

Journal of Surgical Case Reports

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Carcinosarcoma is a distinct neoplasm consisting of bidirectional differentiation toward epithelial and mesenchymal cells. Bladder localization is rare and the association with a rahbdomyoblastic component is exceptional. Few cases of bladder carcinosarcoma with rhabdomyoblastic differentiation have been reported in the literature. We present a case of a bladder carcinosarcoma in a 68-year-old man who presented with terminal hematuria and discuss difficulties of diagnostic and treatment.

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Development and validation of a prognostic nomogram for predicting overall survival in patients with primary bladder sarcoma: a SEER-based retrospective study

Chen

2021

BMC Urol

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Background Primary bladder sarcoma (PBS) is a rare malignant tumor of the bladder with a poor prognosis, and its disease course is inadequately understood. Therefore, our study aimed to establish a prognostic model to determine individualized prognosis of patients with PBS. Patients and Methods Data of 866 patients with PBS, registered from 1973 to 2015, were extracted from the surveillance, epidemiology, and end result (SEER) database. The patients included were randomly split into a training (n = 608) and a validation set (n = 258). Univariate and multivariate Cox regression analyses were employed to identify the important independent prognostic factors. A nomogram was then established to predict overall survival (OS). Using calibration curves, receiver operating characteristic curves, concordance index (C-index), decision curve analysis (DCA), net reclassification improvement (NRI) and integrated discrimination improvement (IDI), the performance of the nomogram was internally validated. We compared the nomogram with the TNM staging system. The application of the risk stratification system was tested using Kaplan–Meier survival analysis. Results Age at diagnosis, T-stage, N-stage, M-stage, and tumor size were identified as independent predictors of OS. C-index of the training cohort were 0.675, 0.670, 0.671 for 1-, 3- and 5-year OS, respectively. And that in the validation cohort were 0.701, 0.684, 0.679, respectively. Calibration curves also showed great prediction accuracy. In comparison with TNM staging system, improved net benefits in DCA, evaluated NRI and IDI were obtained. The risk stratification system can significantly distinguish the patients with different survival risk. Conclusion A prognostic nomogram was developed and validated in the present study to predict the prognosis of the PBS patients. It may assist clinicians in evaluating the risk factors of patients and formulating an optimal individualized treatment strategy.

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Carcino-sarcoma of the urinary bladder with cartilaginous differentiation: About a case report

Cited by 3 publications

References 4 publications

Carcinosarcoma is an aggressive subtype of bladder cancer: A population‐based study

Carcinosarcoma is an aggressive subtype of bladder cancer: A population‐based study

OUP accepted manuscript

Development and validation of a prognostic nomogram for predicting overall survival in patients with primary bladder sarcoma: a SEER-based retrospective study

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