Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule

Benchimol, S; Fuks, Abraham; Jothy, Serge; Beauchemin, Nicole; Shirota, Kinji; Stanners, Clifford P.

doi:10.1016/0092-8674(89)90970-7

Cited by 887 publications

(491 citation statements)

References 25 publications

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“…CEA is overexpressed primarily by adenocarcinomas including colon, rectum, breast, and lung and more than 90% of primary colorectal carcinomas produce CEA [19]. In colon cancer, CEA modulates intercellular adhesion and functions as a promoter of cellular aggregation [20,21], suggesting that CEA has an important role as a facilitator of tumor invasion and metastasis. Nakamura et al [22] reported that seven clinicopathological variables, including undifferentiated tumors, deep tumor invasion, lymphatic and venous invasion, node metastasis, liver metastasis, and advanced stages were significantly greater for patients with a positive CEA (>5 ng/ml) than for patients with a negative CEA (<5 ng/ml).…”

Section: Discussionmentioning

confidence: 99%

Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer

Huh

Kim

et al. 2010

Journal of Surgical Oncology

111

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Objective: We evaluated the prognostic value of the preoperative serum carcinoembryonic antigen (CEA) level in patients with colon cancer. Methods: We reviewed 474 patients who underwent potentially curative resection for nonmetastatic colon cancer. Patients were categorized into two groups according to the preoperative serum CEA level: low CEA (<5 ng/ml) and high CEA ( 5 ng/ml) groups. Results: During the median 45-month follow-up period, the 5-year overall and disease-free survival rates for patients with a low CEA level were 81.7% and 82.4%, respectively, which were significantly higher than the rates for those with a high CEA level (69.9%; P ¼ 0.011 and 70.6%; P ¼ 0.002, respectively). A multivariate analysis revealed that a preoperative serum CEA level was a significant independent prognostic factor for both overall survival (P ¼ 0.021) and disease-free survival (P ¼ 0.026). Both the overall and disease-free survival rates in patients with stage II tumors differed significantly between the low and high CEA groups, whereas the rates did not different between those with stage I and III tumors. Conclusions: Preoperative serum CEA is a reliable predictor of recurrence and survival after curative surgery in patients with colon cancer, particularly in those classified as having stage II disease.

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Section: Discussionmentioning

confidence: 99%

Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer

Huh

Kim

et al. 2010

Journal of Surgical Oncology

111

View full text Add to dashboard Cite

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“…In vitro studies using tumor cells have demonstrated that several CEA subfamily members, notably CEACAM1, CEA (CEACAM5) and CEACAM6, can act as homophilic and heterophilic cell adhesion molecules when expressed on the tumor cell surface (Benchimol et al, 1989). Another study suggested that CEAs play an important role in protecting the colonic mucosa from microbial invasion (Hammarstro¨m, 1999).…”

Section: Introductionmentioning

confidence: 99%

CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-β signaling

et al. 2007

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The carcinoembryonic antigen (CEAs) family consists of a large group of evolutionarily and structurally divergent glycoproteins. The transforming growth factor-b (TGF-b) signaling pathway has been implicated in the stimulation of CEA secretion in TGF-b-sensitive colon cells, thereby possibly modulating cell adhesion and differentiation. However, the specific CEAs targeted by TGF-b signaling or underlying mechanism of the expression of CEAs has not yet been clarified. In this study, we investigated the specific CEAs targeted by the TGF-b signaling pathway. In nine human gastric cancer cell lines examined, TGF-bresponsive cell lines showed positive expression of CEAs. Expression patterns of CEA proteins correlated well with the level of CEA (CEACAM5) and CEACAM6 transcripts in these cell lines, but CEACAM1 expression was not observed in all of these cells. To investigate the role of TGF-b signaling in CEA expression, we selected two TGFb unresponsive gastric cancer cell lines; SNU638 cells that contain a mutation in the TGF-b type II receptor and SNU484 cells that express low to undetectable level of the TGF-b pathway intermediate protein, Smad3. Restoration of TGF-b signaling in these cells induced expression of the CEAs and increased activity of both CEA (CEACAM5) and CEACAM6 promoters. CEA expression was observed in the epithelium of the stomach of wild-type mice, but was markedly decreased in Smad3 null mice. These findings suggest that CEA (CEACAM5) and CEACAM6 are major target genes for Smad3-mediated TGF-b signaling.

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“…It is an intercellular adhesion glycoprotein with a molecular mass of ~180 kDa, belonging to the immunoglobulin superfamily (18). CEA is expressed at low levels in the embryonic and foetal gut, adult colon epithelium and other endodermal tissues (19).…”

Section: Discussionmentioning

confidence: 99%

Clinical factors in prediction of prognosis after anterior resection with total mesorectal excision for carcinoma of the rectum

Szynglarewicz¹,

Matkowski²,

Forgacz³

et al. 2007

Oncol Rep

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Abstract. The aim of the study was to estimate the long-term results and the prognostic value of clinical and pathological factors following R0 anterior resection with total mesorectal excision (TME). Ninety-eight consecutive patients with histologically confirmed rectal cancer were studied prospectively with five-year follow-up. Survival was calculated using the Kaplan-Meier method and differences between curves were tested by the log-rank test. Multivariate analysis was performed using the Cox regression model. Recurrence-free survival (RFS) was 63.6%. Mean time of recurrence was 13.8 months (range 3-38). Local recurrence rate was 7.8% with the mean time of 12.7 months (range 3-25). In univariate analysis Dukes' stage (RFS for stage: A=93.2%; B=53.8%; C=26.3%) and preoperative CEA serum level (s-CEA) (for s-CEA ≤5 ng/ml RFS=93.8%; for s-CEA >5 ng/ml RFS = 5.9%) significantly influenced survival (P<0.005 and P<0.00001). These parameters were also found to be independent prognostic factors in multivariate analysis (P<0.05 and P<0.00001). Survival was worse in older female patients with low-localised poorly differentiated tumors; however, those variables had not significant impact on prognosis. Neither symptom duration nor mucinous histology was significantly related to survival. Using TME technique a low local recurrence rate resulting in improved survival can be achieved. Apart from clinicopathological staging, elevated s-CEA can identify patients with poor prognosis. In addition to TME adjuvant therapy for this high-risk group should be considered.

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Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule

Cited by 887 publications

References 25 publications

Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer

Preoperative carcinoembryonic antigen level as an independent prognostic factor in potentially curative colon cancer

CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-β signaling

Clinical factors in prediction of prognosis after anterior resection with total mesorectal excision for carcinoma of the rectum

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