Carcinogenesis and Bacillus Calmette-Guérin (BCG) Intravesical Treatment of Non-Muscle-Invasive Bladder Cancer under Tryptophan and Thymine Supplementation

Ossick, Marina Vian; Assalin, Heloísa Balan; Kiehl, Isis Ga; Salustiano, Ana Clara C; Rocha, George J. M.; Ferrari, Karen L.; Linarelli, Maria C B; Degasperi, Giovanna Rosa; Reis, Leonardo Oliveira

doi:10.1080/01635581.2020.1856389

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…Traditional TURBT, on the other hand, uses annular electrodes to perform layered resection of the tumor, and the excised tissue is relatively small, with each tissue undergoing electrocoagulation and burning, which is not conducive to pathological staging. e greater the contact surface with the tumor, the greater the extrusion pressure, the more bleeding, and the greater the risk of obturator nerve reflex due to bladder perforation [9,10].…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of the Efficacy of Transurethral Bipolar Plasma Needle Electrode and Ring Electrode in the Treatment of Non-Muscle-Invasive Bladder Cancer

Zheng

Zhang

Zhu

et al. 2022

Computational Intelligence and Neuroscience

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Bladder cancer is the most prevalent tumor of the urinary tract, ranking seventh in males and seventeenth in women. The gold standard for the definitive diagnosis and initial treatment of non-muscle-invasive bladder cancer is transurethral resection (TUR) of the bladder tumor. The ability to accurately detect disease, typically in the presence of hematuria as well as to detect early recurrent tumors in patients with a history of NMIBC, is critical to the successful treatment of non-muscle-invasive bladder cancer (NMIBC). Unfortunately, the current biomarker landscape for NMIBC is still evolving. Cystoscopy remains the gold standard, but it can still miss 10% of tumors. As a result, physicians frequently employ additional diagnostic tools to aid in the diagnosis of bladder cancer. The efficacy of transurethral bipolar plasma needle electrodes and ring electrodes in the treatment of non-muscle-invasive bladder cancer was compared and analyzed in this study. During our study, 100 patients with non-muscle-invasive bladder cancer admitted to our hospital between June 2019 and June 2020 were randomly assigned to a control group and an observation group, with 50 cases in each group. The observation group was given a bipolar plasma needle electrode, while the control group was given a bipolar plasma ring. Patients continued to receive bladder irrigation chemotherapy as well as traditional Chinese medicine (TCM) treatment as part of our treatment plan, while the control group received only bladder irrigation chemotherapy. Clinical factors such as operational blood loss, catheter indention time, length of hospital stay, and others were compared between the two groups. When the risk grades in the two groups were compared, the observation group had fewer medium- and high-risk grades than the control group, but the control group had more low-risk grades, with statistical significance (P < 0.05).

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Section: Introductionmentioning

confidence: 99%

Comparative Analysis of the Efficacy of Transurethral Bipolar Plasma Needle Electrode and Ring Electrode in the Treatment of Non-Muscle-Invasive Bladder Cancer

Zheng

Zhang

Zhu

et al. 2022

Computational Intelligence and Neuroscience

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“…In polycystic ovary syndrome (PCOS) patients with insulin resistance, thymine was found to be increased in follicular fluid compared to that in non-insulin-resistant PCOS patients ( 38 ). In addition, tryptophan and thymine supplementation was able to inhibit urothelial carcinogenesis and potentiate intravesical Bacillus Calmette–Guérin in the treatment of bladder cancer ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

“…The PP model group was established in the same way as the abovementioned described method. The thymine-treated group was supplemented with thymine (gavage, 1 g/kg/day, S18065, Shanghai Yuanye Bio-Technology Co., Ltd.) after PP modeling ( 17 ). Each group had 12 rats; 6 rats were used to observe the time of vaginal opening, and the remaining 6 rats were used for sample collection.…”

Section: Methodsmentioning

confidence: 99%

Multi-omic analysis of precocious puberty girls: pathway changes and metabolite validation

Zhou,

Mao,

Jin

et al. 2024

Front. Endocrinol.

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ObjectivePrecocious puberty (PP) is a prevalent endocrine disorder affecting the physical and mental wellbeing of children. Identifying the triggering factors of PP has become a central issue. This study seeks to investigate the metabolomic and transcriptomic alterations in PP.Material and methodsFirst, 37 school-aged girls diagnosed with PP and 25 age-matched prepubertal control girls were recruited, and the fecal samples were collected for non-targeted metabolomic analysis to screen for differentially expressed metabolites (DEMs). Subsequently, an animal model of PP was constructed by danazol administration to neonatal female rats, and both fecal non-targeted metabolomics and serum next-generation transcriptomic sequencing were performed to screen DEMs and differentially expressed genes (DEGs) in PP. Moreover, the DEM co-existing in clinical and animal models was administrated to PP rats to explore the role of the target metabolite in PP.ResultsA total of 24 DEMs in PP clinical samples and 180 DEMs and 425 DEGs in PP animal samples were identified. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that these DEMs and DEGs were enriched in disease-associated pathways, including fatty acid synthesis, glycerolipid metabolism, pyrimidine metabolism, steroid hormone biosynthesis, progesterone-mediated oocyte maturation, and gonadotropin-releasing hormone (GnRH) signaling pathway, forming a tight DEM–DEG pathway regulatory network. Further DEM validation demonstrated that thymine supplementation delayed the opening of the vagina and development of PP in model rats.ConclusionThis study reveals that the metabolomic and transcriptomic changes, along with enriched pathways, are implicated in PP based on clinical and animal analyses. The findings may provide new strategies and research avenues for PP treatment.

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“…The potential to modulate the activity of the immune system by interventions with specific nutrients is termed immunonutrition that may be applied to any situation in which an altered supply of nutrients is used to modify inflammatory or immune responses 5 . The nutrients most often studied were arginine, glutamine, branched‐chain amino acids, n‐3 fatty acids, tryptophan and nucleotides like thymine 6 …”

Section: Introductionmentioning

confidence: 99%

“…5 The nutrients most often studied were arginine, glutamine, branched-chain amino acids, n-3 fatty acids, tryptophan and nucleotides like thymine. 6 The immunonutrition has the potential to counteract cancer patients' usual adverse situations (malnutrition and impaired immune function) positively influencing their recovery. In this scenario, Oncoxin Oral Solution (OOS) is an oral nutritional supplement that includes recognised anti-cancer antioxidants (green tea's polyphenols, epigallocatechin 3-gallate, vitamin B6 and vitamin C), antiinflammatories, immunomodulators (cinnamic and glycyrrhizin acids), L-arginine and L-cysteine.…”

mentioning

confidence: 99%

Immunonutrition hope? Oral nutritional supplement on cancer treatment

2021

Self Cite

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Cancer's natural history and clinical outcome depend upon complex interactions among tumour cells, the immune system and host body homeostasis. Oncoimmunology is a new pillar of cancer therapy adding to surgery, chemo-and radiotherapy, and it is just the tip of an iceberg of new opportunities to improve patient recovery, recently demonstrated by the strategies that have motivated the 2018 Nobel Prize in Medicine. [1][2][3] A hyperinflammatory state depletes antioxidant defences and suppresses lymphocyte function. In cancer patients, immunosuppression installs by diverse mechanisms, including increased inflammatory and oxidant stress. However, reactive oxygen species (ROS) or nitric oxide, reactive nitrogen species may play a double-faced role in cancer, entailing protumorigenic and tumour-suppressing effects in early and later stages, respectively. In that sense, antioxidants could be deleterious in the escape phase (3rd phase) during which ROS or nitric oxide would have a pro-tumour effect, depending on

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Carcinogenesis and Bacillus Calmette-Guérin (BCG) Intravesical Treatment of Non-Muscle-Invasive Bladder Cancer under Tryptophan and Thymine Supplementation

Cited by 6 publications

References 30 publications

Comparative Analysis of the Efficacy of Transurethral Bipolar Plasma Needle Electrode and Ring Electrode in the Treatment of Non-Muscle-Invasive Bladder Cancer

Comparative Analysis of the Efficacy of Transurethral Bipolar Plasma Needle Electrode and Ring Electrode in the Treatment of Non-Muscle-Invasive Bladder Cancer

Multi-omic analysis of precocious puberty girls: pathway changes and metabolite validation

Immunonutrition hope? Oral nutritional supplement on cancer treatment

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