Carcinogenesis by Ultraviolet Light

Blum, Harold F.

doi:10.1515/9781400879922

Cited by 294 publications

(97 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Blum (1959) described that there occurred rapid churning or cyclic movement in the cytoplasm within a few minutes after exposure of cells to ultraviolet rays. It is thus conceivable that a prompt change may occur in viscosity at the irradiated area, and as a result the cytoplasm around it may flow into the region creating a cytoplasmic streaming.…”

Section: Discussionmentioning

confidence: 99%

Unusual Movement of the Daughter Chromosome Group in Telophasic Cells Following the Exposure to Ultraviolet Microbeam Irradiation

Nakanishi¹,

Kato²

1965

CYTOLOGIA

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Unusual Movement of the Daughter Chromosome Group in Telophasic Cells Following the Exposure to Ultraviolet Microbeam Irradiation

Nakanishi¹,

Kato²

1965

CYTOLOGIA

View full text Add to dashboard Cite

“…3). (Blum, 1959) and for leukaemia in atomic bomb survivors with increase in radiation doses or decreased age at time of bombing (Ichimaru and Ishimaru, 1975). Stem cells will be newly born more frequently from damage-free stem cells than from damagebearing ones, resulting in natural selection of fitter stem cells.…”

Section: Time Of Fixation and Expression Of Mutations And Neoplasiamentioning

confidence: 99%

A test for mutation theory of cancer: Carcinogenesis by misrepair of DNA damaged by 4-nitroquinoline 1-oxide

Kondo¹

1977

Br J Cancer

View full text Add to dashboard Cite

Summary.-Evidence for a mutation theory of cancer is presented by reviewing the experimental work on 4-nitroquinoline 1-oxide (4NQO) carcinogenesis. 4NQO almost completely mimics u.v. light and produces 4NQO-purine adducts on DNA. When 4NQO-treated cells are held in liquid medium under appropriate conditions, the 4NQO adducts disappear from DNA, in parallel to decrease of premutational damage in Escherichia coli, or pretransformational damage in cultured mouse cells. Post-treatment with caffeine greatly diminishes the yields by 4NQO of mutants in E. coli, malignant transformants in cultured mouse cells and tumour nodules in the lung of mice. Potentially tumourigenized stem cells in the lung remain sensitive to selective killing by caffeine for at least 5 days after 4NQO treatment, in spite of their DNA being apparently replicated, an indication that carcinogen-damaged DNA in the stem cell can be transmitted to its successive daughter stem cells for many generations. This peculiar characteristic is discussed as a possible lead to the crux of the mutation theory of cancer in vivo, and a model for carcinogenesis is proposed.

show abstract

“…Already, in laboratory experimental work, Blum (1955) has found the integrated normal curve to be appropriate to the production of skin cancers in albino mice by ultraviolet radiation. However, it has recently been questioned whether these observations are transferable to the situation in man.…”

Section: Fitting Suitable Curvesmentioning

confidence: 99%

“…Solar cancers might be regarded as one of the simplest and most straightforward examples of carcinogenesis that can be studied in man. However, even in this instance there is disagreement about the importance of the melanin pigment and thickness of the stratum corneum as protective factors against solar radiation (Mackie and McGovern, 1958;Blum, 1959;Thomson, 1955). Until some of the biological difficulties are resolved, the appropriateness of various theoretical models of carcinogenesis cannot be adequately assessed.…”

Section: Estimates Of Average Riskmentioning

confidence: 99%