Carcinogenesis induced by black pepper (Piper nigrum) and modulated by Vitamin A

Shwaireb, Mohamed H.; Wrba, H.; El‐Mofty, M.M.; Dutter, A

doi:10.1016/s0232-1513(11)80307-5

Cited by 16 publications

(7 citation statements)

References 18 publications

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“…While a number of studies suggest that black pepper has anticancer properties, numerous reports have emerged suggesting that various portions of Piper nigrum plant, as well as its inherent constituents, safrole and tannic acid, can induce tumors and magnify the proliferation of malignant cells (Shwaireb et al , 1990). Feverfew ( Tanacetum parthenium ) also has a host of medicinal properties which include prophylaxis of migraine, antiinflammatory, antithrombotic effects and antitumor effects.…”

Section: Discussionmentioning

confidence: 99%

In vitroscreening for the tumoricidal properties of international medicinal herbs

Mazzio

Soliman

2008

Phytotherapy Research

141

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There is growing use of anticancer complementary and alternative medicines (CAMs) worldwide. The purpose of the current study is to assess a sizeable variety of natural and plant sources of diverse origin, to ascertain prospective research directives for cancer treatment and potential new chemotherapy drug sources. In this study, 374 natural extracts (10 μg/mL-5 mg/mL) were evaluated for dose-dependent tumoricidal effects using immortal neuroblastoma of spontaneous malignant origin. The findings indicate no pattern of tumoricidal effects by diverse plants with similar families/genus under the classes Pinopsida, Equisetopsida, Lycopodiosida, Filicosida, Liliopsida Monocotyledons or Magnoliopsida Dicotyledons. The results indicate that many of the most commonly used CAMs exhibited relatively weak tumoricidal effects including cats claw, astragalus, ginseng, echinacea, mistletoe, milk thistle, slippery elm, cayenne, chamomile, don quai, meadowsweet, motherwort and shepherd's purse. The data demonstrate that the most potent plant extracts were randomly dispersed within the plantae kingdom (LC 50 = 31-490 μg/mL) in order of the lowest LC 50 Dioscorea villosa (Dioscoreaceae) > Sanguinaria canadensis (Papaveraceae) > Dipsacus asper (Dipsacaceae) > Populus balsamifera (Salicaceae) > Boswellia carteri (Burseraceae) > Cyamopsis psoralioides (Fabaceae) > Rhamnus cathartica (Rhamnaceae) > Larrea tridentate (Zygophyllaceae) > Dichroa febrifuga (Hydrangeaceae) > Batschia canescens (Boraginaceae) > Kochia scoparia (Chenopodiaceae) > Solanum xanthocarpum (Solanaceae) > Opoponax chironium (Umbelliferae) > Caulophyllum thalictroides (Berberidaceae) > Dryopteris crassirhizoma (Dryopteridaceae) > Garcinia cambogia (Clusiaceae) > Vitex agnus-castus (Verbenaceae) > Calamus draco (Arecaceae). These findings show tumoricidal effect by extracts of wild yam root, bloodroot, teasel root, bakuchi seed, dichroa root, kanta kari, garcinia fruit, mace, dragons blood and the biblically referenced herbs: balm of gilead bud, frankincense and myrrh gum.

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Section: Discussionmentioning

confidence: 99%

In vitroscreening for the tumoricidal properties of international medicinal herbs

Mazzio

Soliman

2008

Phytotherapy Research

141

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“…Cubeb berry and black pepper derived from the Piper genus (LC 50 = 0.263 mg/mL), has a long touted historical application having both use as a food spice and medicinally to maintain the health of urinary tract, prostate and to treat dysentery, gonorrhea, bronchitis, hepatitis, inflammation and pain. While a number of studies suggest that black pepper has anticancer properties, numerous reports have emerged suggesting that various portions of Piper nigrum plant, as well as its inherent constituents, safrole and tannic acid, can induce tumors and magnify the proliferation of malignant cells (Shwaireb et al, 1990). Feverfew (Tanacetum parthenium) also has a host of medicinal properties which include prophylaxis of migraine, antiinflammatory, antithrombotic effects and antitumor effects.…”

Section: Potent Plant Extracts With Known Side Effectsmentioning

confidence: 99%

In vitro screening of tumoricidal properties of international medicinal herbs: part II

Mazzio

Soliman

2010

Phytotherapy Research

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With growing use of anticancer complementary and alternative medicines (CAMs) worldwide, there is a need to assess and screen commercially available natural products for relative tumoricidal properties under standard experimental conditions. In the current study, we screened and ranked 264 traditional Chinese and Egyptian herbal medicines for tumoricidal potency against malignant neuroblastoma in vitro. The data obtained show that tumoricidal potencies of plants were randomly dispersed throughout similar orders, families and genera under the Division: Magnoliophyta, class: Magnoliopsida, subclasses: Asteridae, Caryophyllidae, Dilleniidae, Hamamelididae, Magnoliidae and Rosidae. The most potent plant extracts (LC 50 < 0.08 mg/ml) were prepared from gromwell root also known as 'Hong Tiao Zi Cao' (Lithospermum Erythrorhizon) Family (Boraginaceae) > beth root (Trillium Pendulum), Family (Liliaceae) and galbanum (Ferula Galbaniflua), Family (Apiaceae). Gromwell root is traditionally used in the preparation of Chinese medicinal tea. In addition, galbanum was highly regarded for its sacred and medicinal value according to ancient texts and the bible. Future research will be required to isolate and identify chemical constituents within these plants which are responsible for tumoricidal effects.

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“…Mice were divided into two groups of seven each. Group I receiving 0.1 ml of double distilled water served as control, while Group II, treated with the water extract of Piper fruits at the dose of 4mg/kg (taken from Shwaireb et al, 1990) was considered as the treated group. The drug~and the vehicle were administered by gastric intubations between 11:00 and 12:00h of the day to avoid circadian interference and the treatment was continued for 15 days.…”

Section: Expt I: Effects Of Water Extractmentioning

confidence: 99%

“…As medicine, it is believed to cure sore throat, skin diseases, flatulence, arthritis and various gastric ailments (Sivarajan & Balachandran, 1994). Some reports on this plant have also indicated its toxic effects (Shwaireb et al, 1990;Piyachaturawat et aI., 1995;Daware et aI., 2000). In order to ascertain whether its effects are based on the type of preparation, in the present investigation a study was made with aqueous and alcohol extracts on the thyroid function of mice.…”

Section: Introductionmentioning

confidence: 98%

Water and Ethanol Extracts ofPiper nigrumin Regulating Thyroid Function and Lipid Peroxidation in Mice

Panda

Kar

2003

Pharmaceutical Biology

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An investigation was made to evaluate the effects of water and ethanol extracts of Piper nigrum L. fruits in the alteration ofthe serum thyroid hormone concentrations and tissue lipid peroxidation in liver, the main target organ of many drugs. The alcohol extract, at a dose of 4.0mg/kg for 15 days, caused thyrotoxicosis as evidenced by increased concentrations of thyroxine and triiodothyronine. A concomitant increase in hepatic lipid peroxidation with a decrease in superoxide dismutase and/or catalase activities also indicated its peroxidative effect. However, a trial with the aqueous extract did not exhibit any toxic effect either on thyroid or in liver functions. Rather, the latter extract appeared to be antithyroidic and antiperoxidative in nature as it could decrease serum thyroid hormone concentrations and hepatic lipid peroxidation, respectively. It is suggested that the aqueous extract of Piper nigrum may be preferred over the alcohol extract for therapeutic uses.

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Carcinogenesis induced by black pepper (Piper nigrum) and modulated by Vitamin A

Cited by 16 publications

References 18 publications

In vitroscreening for the tumoricidal properties of international medicinal herbs

In vitroscreening for the tumoricidal properties of international medicinal herbs

In vitro screening of tumoricidal properties of international medicinal herbs: part II

Water and Ethanol Extracts ofPiper nigrumin Regulating Thyroid Function and Lipid Peroxidation in Mice

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