<i>In vitro</i>screening for the tumoricidal properties of international medicinal herbs

Mazzio, Elizabeth; Soliman, Karam F.A.

doi:10.1002/ptr.2636

Cited by 141 publications

(51 citation statements)

References 82 publications

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“…The results obtained for both aqueous and methanol extracts of C. papaya against MMS-induced cytotoxicity and mutagenicity explains the moderate antimutagenicity of the plant extract against MMS. In line to this, earlier reports regarding moderate antimutagenic and antitumor activity of C. papaya extracts were reported (Akinboro and Bakare, 2007;Mazzio and Soliman, 2009).…”

Section: Discussionsupporting

confidence: 61%

“…The plant is well known for its fruits & its parts are used for microbial infections (Sharmeen et al, 2012), treating burns & wounds, fever, intestinal nematode infection, asthma, & gastric (Runnie et al, 2004;starleyet al, 1999;Stepek et al, 2004). Moreover, according to Mazzio & Soliman (2009), the extract of papaya leave showed antitumor activity when tested in Neuro-2A cell lines.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of cytotoxic, mutagenic and antimutagenic potential of leaf extracts of three medicinal plants using Allium cepa chromosome assay

Rathnasamy¹,

Mohamed²,

Sulaiman³

et al. 2013

Int Curr Pharm J

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In the present study, the Allium cepa chromosome assay was employed as a preliminary test to investigate the mutagenic and antimutagenic potential of three plants, namely Clinacanthus nutans, Adhatoda vasica, and Carica papaya, used by traditional practitioners in Malaysia against a direct acting mutagen-Methyl Methanesulphonate (MMS). Onions were planted in various treatment groups: plant extract alone, treatment 1 (pre-treatment with MMS and transfer into plant extracts), and treatment 2 (mixture of MMS and plant extracts). The bulbs planted in the extract alone for cytotoxicity and mutagenicity assessment revealed that none of the extracts of the three plants except the 50 mg/kg of methanol extract of A. vasicawere cytotoxic to A. cepa cells, but a moderate level of mutagenicity was observed at 200 and 400 mg/kg of methanol extract of C. papaya and at 400 mg/kg of aqueous extract of C. nutans. Antimutagenic screening on the other hand revealed that all the extracts tested were able to reduce the percentage chromosomal aberration induced by MMS, both in treatment 1 and 2. Besides that, MMS-induced cell death was also observed to be reduced in onion root cells treated with the plant extracts. Therefore, taking all the results obtained into consideration, the order of the plant extracts with increasing suppressiveness against MMS was C. papaya < A. vasica < C. nutans.DOI: http://dx.doi.org/10.3329/icpj.v2i8.15588 International Current Pharmaceutical Journal, July 2013, 2(8): 131-140

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Evaluation of cytotoxic, mutagenic and antimutagenic potential of leaf extracts of three medicinal plants using Allium cepa chromosome assay

Rathnasamy¹,

Mohamed²,

Sulaiman³

et al. 2013

Int Curr Pharm J

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show abstract

“…In order to determine the probable mechanism of growth inhibition, apoptosis and proliferation markers were evaluated; the inhibition occurred through apoptosis and necrosis, as shown by Annexin V/PI apoptosis assay. cer cell lines, such as bladder cancer by up-regulation of several pro-apoptotic genes, such as Il-6, CDKN1a and TNFa1 (10). Also, Frankincense oil revealed to have influence on the expression of Akt protein, an important protein in regulation of p53.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Jaafari‐Ashkavandi¹,

Hamedi²,

Assar³

et al. 2017

Int J Cancer Manag

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Background: Cytotoxic effects of Frankincense resin have been shown on some cancer cell lines. Due to its low side effects, this study was designed to evaluate the anticancer properties of water soluble elements of Frankincense oleo-gum-resin on human oral squamous cell carcinoma cell line. Methods:Oleo-gum-resin was macerated in ethanol. After filtration, the water soluble fraction of dried residue was extracted. KB cells were treated with 0, 62.5, 125, 250 and 500 µg/mL concentrations of obtained Frankincense aqueous fractions and with Doxorubicin as positive control. Frankincense induced cell cytotoxicity; apoptosis and proliferation were investigated using WST assay, Annexin V-FITC/PI, and Ki-67 staining, respectively. Data were analyzed using Kruskal-Wallis test by SPSS 17 software.Results: IC50 of 137.21 µg/mL was obtained from Frankincense aqueous fraction after 48 hours. The percentage of apoptotic cells was elevated in a time-and dose-dependent manner. There was no statistical difference in the Ki-67 expression of KB cells, using different concentration of Frankincense aqueous fraction after 24 and 48 hours (P = 0.083). Doxorubicin inhibited cells growth essentially through apoptosis. Conclusions:Frankincense aqueous fractions seem to suppress KB cell growth through the induction of apoptosis and necrosis rather than the inhibition of proliferation and hence might be a potential anticancer agent. Structural analysis and purification of potent components are suggested for determining more definitive results.

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“…In similar studies, the cytotoxic effect of essential oil of K. scoparia on MDA-MB-231 cancer cells (breast cancer cell line) and oral squamous carcinoma cell line (OSCC) has been shown by Hey-yeon et al [6]. Mazzio and Soleiman found the antitumor effect of the essential oil of K. scoparia in their study [12] [15]. Based on our findings, the essential oils of red clover and K. scoparia inhibit the proliferation of the MCF-7 breast cancer cell line.…”

Section: Discussionmentioning

confidence: 70%

Anti-tumor Effects of Essential Oils of Red Clover and Ragweed on MCF-7 Breast Cancer Cell Line

Kianinodeh

Tabatabaei

Alibakhshi

et al. 2017

mcij

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Introduction: Breast cancer is one of the most common malignancies among Iranian women. Nowadays, the use of traditional medicinal plants has emerged as a tempting complementary to the treatment of breast cancer due to minimal side effects and less documented drug resistance. The aim of this study was to examine the anticancer effects of the essential oils of red clover and mature fruit of Bassia scoparia on MCF-7 cells. Methods: Essential oils were extracted from Bassia scoparia and red clover plants, by a Clevenger condenser and mass spectrometry was performed for qualitative analysis, then MCF-7 and HU02 cells were treated with different concentrations of these essential oils at different time intervals. The viability of cells was measured by the MTT assay. The results were analyzed using the one-way ANOVA and Tukey′s test. Results: Essential oils of Kochia scoparia and red clover have cytotoxic effects on MCF7 cells. The MTT analysis showed decreased cell viability percentage in treated cells (P < 0.05). In addition, the microscopic examination of cells treated with essential oils revealed morphological changes of apoptotic cells in MCF-7 cells. Conclusions: The findings of this study show that essential oils of Bassia scoparia and Red clover have toxic and anticancer effects on MCF-7 cells.

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In vitroscreening for the tumoricidal properties of international medicinal herbs

Cited by 141 publications

References 82 publications

Evaluation of cytotoxic, mutagenic and antimutagenic potential of leaf extracts of three medicinal plants using Allium cepa chromosome assay

Evaluation of cytotoxic, mutagenic and antimutagenic potential of leaf extracts of three medicinal plants using Allium cepa chromosome assay

The Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Anti-tumor Effects of Essential Oils of Red Clover and Ragweed on MCF-7 Breast Cancer Cell Line

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