Carcinogenesis Studies in Rodents for Evaluating Risks Associated with Chemical Carcinogens in Aquatic Food Animals

Abstract

FIsh and selish caught in polluted waters contain poentially dangerous amounts ofti an carcinogenic l Public concern was heightened when a large percentage ofwinter founder taken from Boston Harbor wa found to have visiblecancer ofthe Diver; winterflounderoutsidetheesuary ara had no livwerlesons. LIng-tenn cbemicalcardnogenesis sudies could be esily and feasibly designd using laboratory rodentsoffred diet _contaling fshcaught in pollted waters.Induced cancers in rodents would corroborate field observations in fish; positive results from these studies would provide futhe evienc about potenti human health hazards from eaing s l amounts of emlly ontaminated fish. Nonetheless, fish and aquatic orgnisms should be viewed as environmental biological monitors of polution or of potential human heth harwds, and authoritis responsible for asuring clan and safe rivers, bodies ofwater, and biota should give more attention to these valid biological indicators or sentinels ofenvhinmental polution. Consequendy, fish and other sea creatures alone should serve as alarms regarding whether water areas constitute public health hazards.

Chemicals and Cancer in Humans: First Evidence in Experimental Animals

“…One simply has to design more innovative experimental protocols to better evaluate likely correspondence in animals. Environmental sentinels have proven useful for identifying "carcinogenic environs," such as fish with liver tumors in Boston Harbor and elsewhere (56).…”

Critical Effective Methods to Detect Genotoxic Carcinogens and Neoplasm-Promoting Agents

“…The traditional chrnic bioassay in rodents is an importnt tool to examine whether or not a given chemical represents a cancer risk for man (42,43 (46)(47)(48)(49)(50). Thus, the in vitro tests and biochemical studies necessarily precede a chronic rodent bioassay so as to be in a position to design the bioassay in the light of the findings made (Si).…”

Finfish and aquatic invertebrate pathology resources for now and the future

“…More recently, diverse nonmammalian aquatic species have been used increasingly to detect mutagens (Anderson and Wild, 1994; Shima and Shimada, 1994), carcinogens (Couch and Harshbarger, 1985; Huff et al, 1991), and endocrine disruption worldwide (Blazer et al, 2007; Picard-Aitken et al, 2007; Wei et al, 2008). …”