Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice

Dunnick, June K.; Pandiri, Arun R.; Merrick, B. Alex; Kissling, Grace E.; Cunny, Helen; Mutlu, Esra; Waidyanatha, Surayma; Sills, Robert C.; Hong, Hue-Hua L.; Ton, Thai-Vu; Maynor, T; Recio, Leslie; Phillips, Suzanne; DeVito, Michael J.; Brix, Amy E.

doi:10.1016/j.toxrep.2018.05.010

Cited by 40 publications

(44 citation statements)

References 86 publications

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“…Samples of liver, fat and/or plasma were taken for PBDE congener tissue level determinations. Liver tissue samples from control or treated female rats were collected for DNA extraction and AhR genotyping [1] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…This includes methods for the development of plasmid controls to generate AhR DNA, AhR wild and mutant nucleotide sequence, and other details on the AhR genotyping of female Sprague Dawley rats. These data were used in the original paper [1] to determine if the occurrence of PBDE induced liver tumors were related to the AhR genotype.…”

Section: Methodsmentioning

confidence: 99%

“…Data are provided to characterize the AhR genotype of Wistar Han rats used in toxicology studies of pentabrominated diphenyl ether mixture [1] . The AhR genotyping results showed that PBDE-induced liver tumors occurred independently of a mutant or wild type AhR genotype.…”

Section: Datamentioning

confidence: 99%

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Mutational analysis of pentabrominated diphenyl-induced hepatocellular tumors in rats and mice, tissue levels of PBDE congeners in rats and mice, and AhR genotyping of Wistar Han rats

et al. 2018

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This article describes data related to the research article entitled “Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice” (Dunnick et al., 2018). PBDE-induced hepatocellular tumors harbored Hras and Ctnnb1 mutations and the methods for these studies are provided. Tissue levels of PBDE congeners in rats and mice after oral exposure to PBDE mixture increased with increasing dose of PBDE. There was no correlation between AhR status and the incidence of hepatocellular tumors in female Wistar Han rats. This manuscript provides additional information on the methods for conducting mutational analysis, PBDE tissue level determinations, and AhR genotyping.

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Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Mutational analysis of pentabrominated diphenyl-induced hepatocellular tumors in rats and mice, tissue levels of PBDE congeners in rats and mice, and AhR genotyping of Wistar Han rats

et al. 2018

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“…The commonly used ether solvents are diethyl ether, tetrahydrofuran, 1,4-dioxan etc. The ether solvents are toxic, many experimental models showed the toxicity of ether to the HepG2 cells [59], toxicity to blood lymphocytes [60], testicular toxicity [61], carcinogenicity [62]. The tetrahydrofuran (THF) shows CNS toxicity with dizziness, headache, loss of sense of smell and fatigue etc.…”

Section: Ethersmentioning

confidence: 99%

An Overview on Common Organic Solvents and Their Toxicity

Joshi

Adhikari

2019

JPRI

384

156

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Organic solvents are known as carbon-based solvents and their general property is primarily based on their volatility, boiling point, the molecular weight and color. Having enormous hazards associated with the organic solvents, they are used for millions of purposes which alert us to think more on its toxicity points. Almost all of the solvents are hazardous to health, if swallowed or inhaled more than the limit quantity and on contact to the skin most of them cause irritation. Some of the common solvents are acetone, ethyl acetate, hexane, heptane, dichloromethane, methanol, ethanol, tetrahydrofuran, acetonitrile, dimethylformamide, toluene, dimethylsulfoxide etc. Researchers, scientists, workers in the chemical industry and research institutes use these solvents on regular basis leading them to be affected in major aspects. But also, the nearby persons are affected by the contamination to the soil, water, air etc. If constantly exposed with solvents, it will badly affect the function of CNS and other body parts. The level of impact, sign and symptoms will depend on concentration, time, duration, frequency and nature of solvents, leading to common effects like headache, dizziness, tiredness, blurred vision, behavioral changes, unconsciousness, and even(Zimmermann, Mayer et al. 1985) death. To overcome it, the green chemistry concept is growing rapidly, and the solvent selection guide is in practice in many big company and research institute. A researcher or chemical worker is the primary person who works with solvents and they need to consider throughout these things while performing their activities for their own good health and for the sake of the world. The purpose of this review is to provide needed basic knowledge about common organic solvents and their potential toxicities which will alert researchers to think twice and always think for their health as well as for the environment via safe and green practice.

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“…The crude incidence of hepatoblastoma in male mice (1,1,16,5) were reported after treatment of 0 3 15 50 mg/kg pentabrominated diphenyl ether [6] (n i = 50). Assuming dose as a qualitative factor, the proportions were modeled in the generalized linear model with the logit link function and small sample add-2 sample adjustment [2].…”

Section: Crude Tumor Rates In a Long-term Carcinogenicity Studymentioning

confidence: 99%

Statistical approach for …a test chemical is considered to be positive… in regulatory toxicology: Trend and pairwise tests

Hothorn

2019

Preprint

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Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice

Abstract: Graphical abstract

Cited by 40 publications

References 86 publications

Mutational analysis of pentabrominated diphenyl-induced hepatocellular tumors in rats and mice, tissue levels of PBDE congeners in rats and mice, and AhR genotyping of Wistar Han rats

Mutational analysis of pentabrominated diphenyl-induced hepatocellular tumors in rats and mice, tissue levels of PBDE congeners in rats and mice, and AhR genotyping of Wistar Han rats

An Overview on Common Organic Solvents and Their Toxicity

Statistical approach for …a test chemical is considered to be positive… in regulatory toxicology: Trend and pairwise tests

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