Carcinoma base of tongue: Single institution 15 year experiences

Abstract

In locally advanced squamous cell carcinoma of base of tongue tumors concomitant chemoradiotherapy with infusional cisplatinum and 5 fluorouracil results in higher disease free and overall survival as compared to radiotherapy as single modality. This better tumor response with chemoradiotherapy comes at cost of higher incidence of mucosal toxicity.

Clinicopathological evaluation and survival of patients with squamous cell carcinoma of the tongue

“…This study found that tumour size (T stage) and the presence of lymph nodes at diagnosis (N stage) were significant predictors of patient outcomes. This finding indicates that T and N stages can be considered independent factors prognostic of overall survival in this group of patients and that patients without lymph node metastases at initial diagnosis and with T1 or T2 tumours have a higher survival rate (64.92%), confirming previous results ( 10 , 18 ).…”

“…After analysing the high mortality rates evidenced in this study and the published reports, it can be concluded that this is a serious disease because of the difficulties of access to adequate treatment, medical professionals often not able to make the appropriate initial diagnosis, and neglect of patients not seeking care but having habits that trigger the disease, corroborating with several surveys ( 10 - 18 ).…”

“…Other factors as solar radiation exposure and viruses infections, including human papilloma virus (HPV) which are more specific of other SCC, respectively the lip and oropharynx ( 1 , 5 , 11 ). The majority of studies of oral SCC found that all reported alcohol consumption and/or smoking tobacco ( 10 - 18 ).…”

“…According to the Almeida ( 13 ) classification, the main factors influencing patient prognosis and survival include the size and location of the primary tumour, regional lymph node involvement, and the presence of distant metastases, with all of these factors included in TNM stage. Prognosis is significantly better in patients with stage I than stage IV tumors ( 10 , 18 ). This study found that tumour size (T stage) and the presence of lymph nodes at diagnosis (N stage) were significant predictors of patient outcomes.…”