Clinicopathological evaluation and survival of patients 
with squamous cell carcinoma of the tongue

Nóbrega, Thamirys-Dantas; Queiroz, Salomão-Israel-Monteiro-Lourenço; Santos, Edilmar-de Moura; Costa, Antônio de Lisboa Lopes; Pereira-Pinto, Leão; Souza, Lélia Batista De

doi:10.4317/medoral.22421

Cited by 12 publications

(11 citation statements)

References 9 publications

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“…Oral SCC remains as one of the most difficult malignancies to control due to its high tendency for local invasion and cervical lymph node dissemination, especially the tongue and floor of the mouth SCC 16 , 17 . This is the reason why its survival rates remain low, even with advances in therapeutic strategies 18 .…”

Section: Discussionmentioning

confidence: 99%

How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma

et al. 2020

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Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma.Objective:The objective of this study was to investigate the impact of pathological parameters on prognosis of patients affected only by tongue and/or floor of the mouth squamous cell carcinoma (SCC).Methodology:In total, 380 patients treated in the Brazilian National Cancer Institute (INCA) from 1999 to 2006 were included. These patients underwent radical resection followed by neck dissection. The clinical and pathological characteristics were recorded. The Kaplan-Meier method and Cox proportional hazards model were used in survival analysis. Overall survival (OS), cancer-specific survival (CSS) and disease-free interval (DFI) were estimated. Cox residuals were evaluated using the R software version 3.5.2. Worst OS, CSS and DFI were observed in patients with tumors in advanced pathological stages (p<0.001), with the presence of perineural invasion (p<0.001) and vascular invasion (p=0.005).Results:Advanced pathological stage and the presence of a poorly differentiated tumor were independent prognostic factors for OS and CSS. However, advanced pathological stage and perineural invasion were independent predictors of a shorter OS, DFI and CSS.Conclusion:Pathological stage and perineural invasion were the most significant pathological variables in survival analysis in tongue and/or floor of the mouth SCC.

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Section: Discussionmentioning

confidence: 99%

How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma

et al. 2020

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“…In addition to the biological factors of oral cancer, such as cellular aggressiveness, tumor size and presence of cervical metastases, socio-demographic health characteristics may also influence the incidence and severity of oral neoplasms (5-7). Oral squamous cell carcinoma is the most prevalent cancer type affecting oral tissues and advanced stage diagnosis of oral cancer negatively affects patient survival (8). Based on that, determining factors associated with advanced stage lesions are imperative to improve life expectancy of affected individuals.…”

Section: Introductionmentioning

confidence: 99%

Socio-demographic characteristics are related to the advanced clinical stage of oral cancer

Lins

Bezerra²,

Freire³

et al. 2019

Med Oral

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“…Current therapeutic strategies for TSCC include traditional surgical resection, radiotherapy and chemotherapy. Despite advances in these treatments, there has been no significant improvement in the prognosis and survival rate of patients with TSCC over the past 10 years, due to lymphatic metastasis, mortality and recurrence (6,7). The rates of incidence and death remain high (8,9) and the overall 5-year survival rate is less than 60% (10,11).…”

Section: Introductionmentioning

confidence: 99%

Knockdown of ectodysplasin‑A receptor‑associated adaptor protein exerts a tumor‑suppressive effect in tongue squamous cell carcinoma cells

Bai

Han

et al. 2020

Exp Ther Med

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Tongue squamous cell carcinoma (TSCC) is a common malignancy in oral cancer with a high mortality and morbidity. The ectodysplasin-A receptor-associated adaptor protein (EDARADD) is a death domain-containing adaptor protein that interacts with the TNF family ligand ectodysplasin A receptor. It is known that EDARADD has an effect on the development of ectodermal derivative tissues, such as hair and teeth. EDARADD expression is also associated with the development of melanoma. However, the role of EDARADD in TSCC remains unknown. The aim of the present investigation was to explore whether EDARADD plays a role in the biological function of TSCC. Immunohistochemistry was used to measure the expression of EDARADD in TSCC tissues and adjacent normal tissue. EDARADD was knocked down in a TSCC cell line in vitro using a specific lentivirus. The expression level of the EDARADD gene and the efficacy of gene knockdown were evaluated by reverse transcription-quantitative PCR, while EDARADD protein expression and the expression levels of Bcl-2, MYC and NF-κBp65 were determined by western blotting. Additionally, MTT assays, colony formation assays and apoptosis assays were carried out to examine the effect of EDARADD knockdown on the TSCC cells. A previous study showed that the majority of the TSCC tissues that were tested had high EDARADD expression. The expression of EDARADD both at mRNA and protein levels was significantly lower (P<0.01) after the gene was knocked down in the CAL27 cells compared with the level in control cells. Downregulation of EDARADD expression inhibited colony formation and proliferation and induced apoptosis of CAL27 cells when compared to control cells (P<0.01). Taken together, these results suggested that EDARADD may be actively involved in the progression of TSCC and that EDARADD may be a novel therapeutic target for the treatment of TSCC.

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Clinicopathological evaluation and survival of patients with squamous cell carcinoma of the tongue

Cited by 12 publications

References 9 publications

How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma

How pathological criteria can impact prognosis of tongue and floor of the mouth squamous cell carcinoma

Socio-demographic characteristics are related to the advanced clinical stage of oral cancer

Knockdown of ectodysplasin‑A receptor‑associated adaptor protein exerts a tumor‑suppressive effect in tongue squamous cell carcinoma cells

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