Carcinoma ex pleomorphic adenoma of the soft palate

Yoshihara, Toshio; Tanaka, Masayo; Itoh, Michimasa; Ishii, Tetsuo

doi:10.1017/s0022215100129809

Cited by 24 publications

(15 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cancer has been known to manifest in the minor salivary glands in the oral cavity, particularly the hard and soft palate [8,9]. On average, the cancers at these sites tend to be smaller than those arising from the major salivary glands.…”

Section: Clinical Featuresmentioning

confidence: 99%

Carcinoma ex Pleomorphic Adenoma: A Comprehensive Review of Clinical, Pathological and Molecular Data

Antony

Gopalan

Smith

et al. 2011

Head and Neck Pathol

214

243

View full text Add to dashboard Cite

Carcinoma ex pleomorphic adenoma (Ca ex PA) is a carcinoma arising from a primary or recurrent benign pleomorphic adenoma. It often poses a diagnostic challenge to clinicians and pathologists. This study intends to review the literature and highlight the current clinical and molecular perspectives about this entity. The most common clinical presentation of CA ex PA is of a firm mass in the parotid gland. The proportion of adenoma and carcinoma components determines the macroscopic features of this neoplasm. The entity is difficult to diagnose pre-operatively. Pathologic assessment is the gold standard for making the diagnosis. Treatment for Ca ex PA often involves an ablative surgical procedure which may be followed by radiotherapy. Overall, patients with Ca ex PA have a poor prognosis. Accurate diagnosis and aggressive surgical management of patients presenting with Ca ex PA can increase their survival rates. Molecular studies have revealed that the development of Ca ex PA follows a multistep model of carcinogenesis, with the progressive loss of heterozygosity at chromosomal arms 8q, then 12q and finally 17p. There are specific candidate genes in these regions that are associated with particular stages in the progression of Ca ex PA. In addition, many genes which regulate tumour suppression, cell cycle control, growth factors and cell-cell adhesion play a role in the development and progression of Ca ex PA. It is hopeful that these molecular data can give clues for the diagnosis and management of the disease.

show abstract

Section: Clinical Featuresmentioning

confidence: 99%

Carcinoma ex Pleomorphic Adenoma: A Comprehensive Review of Clinical, Pathological and Molecular Data

Antony

Gopalan

Smith

et al. 2011

Head and Neck Pathol

214

243

View full text Add to dashboard Cite

show abstract

“…CXPA predominantly affects the major salivary glands with a majority of cases noted in the parotid and submandibular glands. The cancer has been known to manifest in the minor salivary glands in the oral cavity, particularly the hard and soft palate [54][55][56]. It has a prevalence rate of 5.6 cases per 100,000 malignant neoplasm's and a yearly incidence rate of 0.17 tumors per one million persons [51].…”

Section: Carcinoma Ex Pleomorphic Adenoma / Mixed Malignant Tumormentioning

confidence: 99%

Current Thinking on Malignant Salivary Gland Neoplasms

Arrangoiz¹

2013

JCTR

View full text Add to dashboard Cite

Abstract:Malignant salivary gland neoplasms are rare, representing approximately 3% to 7% of all head and neck cancers. Contrasting from the more common mucosal head and neck cancers, which, in general, are ascribed to excessive tobacco, alcohol use, and more recently to viral infection, specific carcinogenic factors for malignant salivary gland growths have not been as clearly identified. Histologically, they represent a heterogeneous group of tumors. Forty histologic types of epithelial tumors of the salivary glands have been reported; some are exceedingly rare and may be the topic of only a few case reports. Salivary tumors can arise in the major salivary glands or in one of the minor salivary glands (predominantly mucus secreting glands), which are distributed throughout the upper aerodigestive. Most patients who develop malignant salivary gland tumors are in the sixth or seventh decade of life. FNA should be considered as part of the diagnostic evaluation but due to its varying sensitivities and specificities imaging modalities such as ultrasound, CT scans, and MRI should also be used as diagnostic adjuncts. Surgery is the primary modality for management of these tumors, nontraditional surgical approaches and instrumentation, as well as facial nerve monitoring, can be selectively utilized to try and decrease the morbidity associated with these surgical procedures. Adjuvant treatment is primarily achieved with radiation therapy. Chemotherapy continues to have a palliative role in the management of salivary gland tumors; however, research in this field is trying to identify a therapeutic role for chemotherapy in order to improve overall survival.

show abstract

“…Although rare, this condition has been reported to be responsible for 4.5-15% of salivary gland malignancies. [1][2][3] Carcinoma ex pleomorphic adenoma (CXPA) has no distinctive sex predilection, 4 and is more frequent in the 5-6th decades of life. 3 5 These tumours are highly aggressive, with high rates of metastasis, 6 and carry a poor overall prognosis.…”

mentioning

confidence: 99%

“…3 5 These tumours are highly aggressive, with high rates of metastasis, 6 and carry a poor overall prognosis. 4 It has been suggested that a carcinoma may develop within a recurrent PA or when it remains untreated over an extended period of time. 7 8 Despite the recognised clinical importance of CXPA, little is known about its biology.…”

mentioning

confidence: 99%

Maspin expression in carcinoma ex pleomorphic adenoma

Martins

Altemani²,

Freitas³

et al. 2005

J Clin Pathol

View full text Add to dashboard Cite

Aims: To investigate the presence and distribution of the protein maspin in carcinoma ex pleomorphic adenoma (CXPA). Methods: Maspin expression was studied by means of immunohistochemistry in 16 cases of CXPA, using the labelled polymer method. Results: According to the extent of invasion, the tumours were subdivided into: intracapsular (five cases), minimally invasive (four cases), and invasive (seven cases). Twelve patients had carcinoma with only epithelial differentiation, whereas four had a malignant myoepithelial component. Non-luminal cells in the duct-like structures of the remnant pleomorphic adenoma were strongly positive for maspin, whereas only a few luminal cells were immunopositive. A few positive cells were seen in the frequent hypocellular and hyalinised areas. Maspin was abundantly expressed, mainly in non-luminal cells, in transitional areas of CXPA with only epithelial differentiation. In frankly carcinomatous areas there was a gradual decrease in maspin expression. Almost all cells were maspin positive in CXPA with a myoepithelial component. When present, luminal cells were in general negative for maspin. Conclusions: When only epithelial cells undergo malignant transformation, maspin expression is gradually lost. In cases with a myoepithelial component, maspin expression is high, and this might be related to the tumour suppressor activity attributed to this cell. P leomorphic adenoma (PA), the most frequent tumour in salivary glands, can undergo malignant transformation. Although rare, this condition has been reported to be responsible for 4.5-15% of salivary gland malignancies.

show abstract

Carcinoma ex pleomorphic adenoma of the soft palate

Cited by 24 publications

References 17 publications

Carcinoma ex Pleomorphic Adenoma: A Comprehensive Review of Clinical, Pathological and Molecular Data

Carcinoma ex Pleomorphic Adenoma: A Comprehensive Review of Clinical, Pathological and Molecular Data

Current Thinking on Malignant Salivary Gland Neoplasms

Maspin expression in carcinoma ex pleomorphic adenoma

Contact Info

Product

Resources

About