Carcinoma in diverticulum of the female urethra

Leiomyoma in a female urethral diverticulum

“…The etiology is uncertain, although it has been suggested that acquired diverticula may develop as a result of rupture of dilated and infected periurethral glands. 1,4 In addition, urethral injury during childbirth and urethral or vaginal surgery may cause a urethral diverticulum. The incidence of urethral diverticulum is lower in white women (1.1%) than in black women (6.0%), 3 who account for 78%-86% of female urethral diverticulum cases.…”

“…The incidence of urethral diverticulum is lower in white women (1.1%) than in black women (6.0%), 3 who account for 78%-86% of female urethral diverticulum cases. 4 Urethral diverticula are usually located in the posterolateral wall of the middle third of the urethra. 1 Calculi may occur in 1.5%-10.0% of female urethral diverticula.…”

Urinary retention caused by adenocarcinoma arising in recurrent urethral diverticulum

“…In 73% of these, the treatment failed with either local recurrence or distant metastasis [3]. When radiation was used alone, disease-free survival was approximately 33% [4,5].…”

Primary High-grade Serous Carcinoma Arising in the Urethra or Urethral Diverticulum

“…Tumors arising within urethral diverticulae are also rare, accounting for 5% of female urothelial and 0.002% of all female malignancies, with only approximately 100 cases reported to date [reviewed in Ahmed et al (15)]. Unlike primary vaginal and urethral carcinomas, tumors arising in urethral diverticulae are more commonly adenocarcinomas (60%) (15,16). The adenocarcinomas reported to date have been of columnar, mucinous, tubular, or clear cell morphology (15), and we are not aware of any examples of serous carcinoma arising within the urethra or within a urethral diverticulum.…”