Carcinoma in Situ Contrasted With Benign Penetrating Epithelium

Broders, Albert C.

doi:10.1001/jama.1932.02740720024007

Cited by 269 publications

(58 citation statements)

References 9 publications

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“…Subsequent descriptions of the ''earliest histologic changes of cervical cancer'' as surface carcinoma or intraepithelial carcinoma, and later carcinoma in situ (CIS), reflected the histologic descriptions of cells that morphologically looked like cancer but had not invaded below the basement membrane [17][18][19]. The identification of CIS created a 2-tiered clinical approach that fostered hysterectomy for women with CIS and no treatment for women without it (see Figure 2).…”

Section: Mucosal Terminologymentioning

confidence: 99%

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

Darragh

Colgan

Cox

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

641

372

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The terminology for human papillomavirus (HPV)–associated squamous lesions of the lower anogenital tract has a long history marked by disparate diagnostic terms derived from multiple specialties. It often does not reflect current knowledge of HPV biology and pathogenesis. A consensus process was convened to recommend terminology unified across lower anogenital sites. The goal was to create a histopathologic nomenclature system that reflects current knowledge of HPV biology, optimally uses available biomarkers, and facilitates clear communication across different medical specialties. The Lower Anogenital Squamous Terminology (LAST) Project was cosponsored by the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology and included 5 working groups; 3 work groups performed comprehensive literature reviews and developed draft recommendations. Another work group provided the historical background and the fifth will continue to foster implementation of the LAST recommendations. After an open comment period, the draft recommendations were presented at a consensus conference attended by LAST work group members, advisors, and representatives from 35 stakeholder organizations including professional societies and government agencies. Recommendations were finalized and voted on at the consensus meeting. The final, approved recommendations standardize biologically relevant histopathologic terminology for HPV-associated squamous intraepithelial lesions and superficially invasive squamous carcinomas across all lower anogenital tract sites and detail the appropriate use of specific biomarkers to clarify histologic interpretations and enhance diagnostic accuracy. A plan for disseminating and monitoring recommendation implementation in the practicing community was also developed. The implemented recommendations will facilitate communication between pathologists and their clinical colleagues and improve accuracy of histologic diagnosis with the ultimate goal of providing optimal patient care.

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Section: Mucosal Terminologymentioning

confidence: 99%

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

Darragh

Colgan

Cox

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

641

372

View full text Add to dashboard Cite

show abstract

“…He defined a grading system for squamous cancer of the lip in 1920 (12), and also applied it to 362 cases of cancer of the tongue, oral cavity, pharynx, larynx, nasopharynx and paranasal sinuses (13). In 1932, Broders espoused the idea of carcinoma in situ and illustrated an example in the larynx (14). Stout briefly addressed the topic in 1952, but it was not until the 1970s that studies visited laryngeal carcinoma in situ in detail (15).…”

Section: Hnp Between 1900 and 1960mentioning

confidence: 99%

A Brief History of Head and Neck Pathology

Fechner

2002

Modern Pathology

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“…While cases in persons under 20 years of age are uncommon, a few histologically diagnosed cases have been described in such persons (22)(23)(24), the youngest being an infant of 7 months with a cervical adenocarcinoma (25). In 1955, out of 8,804 deaths attributed to cancer of the cervix in the United States, 3 were under 5 years of age and 5 under 20. Perhaps the most reliable data on age incidence of the disease are those from Denmark and Sweden. These data reflect the annual probability that women of various ages will develop or be diagnosed as having the disease.…”

Section: Age Selectionmentioning

confidence: 99%