Carcinoma in situ testis

Skakkebæk, Niels E.; Berthelsen, Jens; Müller, Jørn; Giwercman, Aleksander; Maase, Hans von der; Rørth, Mikael

doi:10.1007/978-3-642-73492-2_60

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…These germ cells (spermatogonia) possibly escaped from the influence of the chemotherapeutic drugs because their cell cycle between two periods of active proliferation was lon ger than the period of chemotherapy administration. Intratubular tumor cells appear to have also relatively low levels of mitotic divisions considering the clinical obser vation of long intervals between CIS and the development of a solid tumor [14], Comprehensive follow-up studies are needed to clarify whether the finding of germ cells in biopsies following therapy may be a risk factor.…”

Section: Discussionmentioning

confidence: 99%

Further Practical Experiences in the Recognition and Management of Carcinoma in situ of the Testis

et al. 1992

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99 biopsies from the contralateral testis in patients with unilateral germ cell tumor were investigated using the semithin section technique. Four cases (4%) revealed a carcinoma in situ (CIS) pattern. Two patients underwent a local radiation (20 Gy), 2 patients received combination chemotherapy (cisplatin, etoposide and bleomycin; PEB). No tumor cells were found in control biopsies 4-8 months after therapy. Both biopsy specimens taken from radiated patients lacked also germ cells. In contrast, 1 patient who was treated with PEB and also another 1 presenting with a teratocarcinoma of apparently retro-peritoneal origin and unilateral CIS revealed germ cells after chemotherapy. The present data suggest radiation therapy to be the first line treatment for CIS-bearing testes. In order to get informations about the distribution of CIS cells in the affected testes, one or two biopsies were additionally taken from macroscopically unsuspicious tissue surrounding various solid germ cell tumors (74 patients). 56 cases (76 %) revealed CIS. Even considering the possibility of missing CIS, a screening biopsy is actually the only method for detecting early manifestations of germ cell tumors and should be performed routinely in contralateral testes of patients with germ cell tumors.

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Section: Discussionmentioning

confidence: 99%

Further Practical Experiences in the Recognition and Management of Carcinoma in situ of the Testis

et al. 1992

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“…Die von uns als Zufallsbefund entdeckte testikuläre intraepitheliale Neoplasie fanden Muller und Skakkebaek ebenfalls als Zufallsbefund bei einem Kind mit TF, bei dem die Hoden prophylaktisch entfernt worden waren [11,17].…”

Section: Diskussionunclassified

Klinisches Management beim Androgeninsensivitätssyndrom

Ruckhäberle¹,

Kissler²,

Lambrecht³

et al. 2006

Zentralbl Gynakol

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The seldom occurring androgen insensitivity syndrome is characterised by male karyotype in a phenotypical women. We report on a complete androgen insensitivity syndrome with the rare coincidence of bilateral Fallopian tubes and a testicular intraepithelial neoplasia. Additionally we discuss aspects of incidence, molecular background, characteristics, diagnostic pitfalls and therapy against the background of the current literature.

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Carcinoma‐in‐situ cells in cultured human seminiferous tubules

Lauke¹,

Seidl²,

Hartmann³

et al. 1991

Int J of Andrology

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For the first time, early germ-cell derived tumour cells were studied in an in-vitro system of cultured seminiferous tubules. The intratubular tumour cells not only survived in culture for 7 days but were also able to multiply. Dividing tumour cells were identified in semi-thin sections and electron micrographs by morphological criteria. Additionally, mitotic activity was demonstrated by [3H]thymidine histo-autoradiography. There are numerous reports on cell lines established from solid non-seminomas, but up to now no references to seminoma cell lines or cultures of intratubular tumour cells are available. The culture of seminiferous tubules offers a tool in making carcinoma-in-situ cells accessible for experimental work.

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Carcinoma in situ testis

Cited by 3 publications

References 22 publications

Further Practical Experiences in the Recognition and Management of Carcinoma in situ of the Testis

Further Practical Experiences in the Recognition and Management of Carcinoma in situ of the Testis

Klinisches Management beim Androgeninsensivitätssyndrom

Carcinoma‐in‐situ cells in cultured human seminiferous tubules

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