Carcinoma of gall bladder: Demographic and clinicopathological profile in Indian patients

Dubey, AP; Rawat, Kavita; Pathi, Nikhil; Sundaram, Vinay; Rathore, Anvesh; Kapoor, Rajan; Pathak, Abhishek

doi:10.4103/oji.oji_1_18

Cited by 8 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…35 Socio-economic scale was described on the Kuppuswamy scale, standardized for India.75 % of patients with GBC belong to the lower-socio-economic status. 40 In another study by Dubey et al lower socio-economic class is correlated with low literacy rate, increased population and limited availability of health related care, inadequate sanitation and reduced access to clean drinking water relative to people of the upper socio-economic class.This, however, is associated with an improved susceptibility to faeco-oral infections such as S. Typhi, H. Pylori. 41 .Some studies assessed the literacy rate in GBC patients and found that lower literacy rates are linked with higher GBC Relative Risk (1.49, 95 per cent CI: 1.3-1.7).…”

Section: Socio-economic Conditionsmentioning

confidence: 96%

Comprehensive review of current trends in adenocarcinoma of gall bladder in northern Indian region: An imperative clinico-histological approach

Bhasker¹

2020

JDPO

View full text Add to dashboard Cite

We are aware that epidemiological studies have established significant geographical and ethnic differences and this disproportionality is quite high in Southeast Asia, but the numbers are few in the America and other parts of world. Age, female gender, congenital biliary tract abnormalities and genetic predisposition represent imperative irreversible risk factors. Environment factors too have been implicated in causing gallbladder carcinoma. Other causes of gall bladder carcinoma include bile duct cholelithiasis, chronic inflammatory conditions and parasite infestation. These occurrences are associated with high mortality rates. Countries with highest gallstone prevalence usually suffer with greatest gallbladder cancer mortality. Indistinct and unclear clinical signs frequently prolong the gallbladder cancer diagnosis and lead to its eventual development and poor prognosis. Therefore, surgery seems to be viable treatment option which is practiced all around the globe since decades. Some patients are lucky to have gallbladder cancer treated incidentally when cholecystectomy is performed for cholelithiasis. This review is an attempt to genuinely explore the current trends in adenocarcinoma of gall bladder in Northern Indian region by clinicohistological approach.

show abstract

Section: Socio-economic Conditionsmentioning

confidence: 96%

Comprehensive review of current trends in adenocarcinoma of gall bladder in northern Indian region: An imperative clinico-histological approach

Bhasker¹

2020

JDPO

View full text Add to dashboard Cite

show abstract

“…Ainda no Chile, observou-se que a implementação desta política transformou a tendência de mortalidade no país, de uma curva ascendente entre 2013). Um estudo piloto realizado com 68 pessoas na Índia analisou a variação sociodemográfica e econômica dos pacientes com câncer de vesícula biliar, neste, 75% dos pacientes selecionados ao acaso, eram pertencentes à classe econômica média-baixa ou baixa (DUBEY et al, 2018). Portanto, nota-se que classes sociais com menor poder econômico detêm menos acesso à educação, à saúde e consequente impacto em fatores de risco modificáveis (DUTTA et al, 2019).…”

Section: Métodosunclassified

Mortalidade por câncer de vesícula biliar no Estado de Sergipe e no Brasil, no período de 2009 a 2019 / Mortality from gallbladder cancer in the State of Sergipe and in Brazil, from 2009 to 2019

Pereira¹,

Santos²,

Batista³

et al. 2022

Braz. J. Hea. Rev.

View full text Add to dashboard Cite

Objetivos: Avaliar a tendência temporal da mortalidade por câncer de vesícula biliar no Brasil e no estado de Sergipe no período de 2009 a 2019. Metodologia: Estudo ecológico, descritivo, de série temporal e de abordagem quantitativa, sobre a mortalidade de câncer de vesícula biliar no Estado de Sergipe e no Brasil, entre 2009 e 2019. Os dados epidemiológicos estudados encontram-se para consulta pública no Sistema de Informação sobre Mortalidade (SIM), disponibilizado no Departamento de Informática do Sistema Único de Saúde (DATASUS). Resultados: Foram identificados 110 óbitos por neoplasia maligna de vesícula biliar no Estado de Sergipe, dos quais 80% foram de mulheres. Observa-se ainda predomínio da faixa etária entre 60-69 anos 30,9%, seguido por 70-79 anos com 26,3%. No Brasil, foram identificados 12.016 óbitos por neoplasia maligna de vesícula biliar, dos quais 73,5% foram de mulheres, e com predomínio na faixa etária com 80 anos ou mais. O Brasil apresentou uma variação percentual anual (VPA) em mulheres de -13,9% (95% IC: -36,3 e 16,5) e em homens de -5,2% (95% IC: -18,5 e 10,2), uma tendência de queda que para o período não foi estatisticamente significativa. No estado de Sergipe, a mortalidade manteve-se estável em todo o período do estudo, para a população feminina que apresentou VPA de -0,6% (95% IC: -6,8 e 6,1), já para os homens, observou-se uma maior VPA com 21,7% (95% IC: 0,5 e 48,8), porém, ambos sem significância estatística. Conclusão: Este estudo fornece dados de registros de câncer de vesícula com base populacional do Brasil e do estado de Sergipe, que confirmam que a as taxas de mortalidade são mais altas entre as mulheres do que os homens, e aumentam significativamente com a idade. A variação na taxa padronizada anual, não refletiu em diferenças estatisticamente significativas, podendo considerar que a mortalidade se manteve estável no período estudado para ambas as populações.Palavras-chave: câncer de vesícula biliar, epidemiologia, mortalidade.

show abstract

Prognostic Insights and Survival Analysis of Gallbladder Cancer in Bihar, India: a Prospective Observational Study Emphasizing the Impact of Surgical Intervention on Overall Survival

Singh,

Mandal

et al. 2024

Indian J Surg Oncol

View full text Add to dashboard Cite

Purpose: The aim of this study was to determine the one-and three-year overall survival rates. Methods:This prospective observational study was conducted at a tertiary care center in Bihar state, India. Results: The study analyzed 228 patients in Bihar with a median age at diagnosis of 55 ± 12.05 years. The most common symptoms included upper abdominal pain (26.3%), weight loss (14%), and ascites (13.6%). The majority of patients presented at stage IV (72.8%), with liver metastasis being prevalent (61.4%). Interventional biliary drainage was performed in 9.6% of cases, and systemic chemotherapy was received by 84.64%, while 15.36% opted for best supportive care. Univariate Cox regression analysis identi ed Eastern Cooperative Oncology Group (ECOG) performance status, stage, gallstone disease, and surgical intervention as signi cant risk factors in uencing overall survival (OS) (p<0.001). Multivariate Cox regression analysis con rmed ECOG performance status (p<0.001), stage (p=0.039), and surgical intervention (p=0.038) as independent factors impacting OS.One-year OS rates for stages II, III, and IV were 100%, 97%, and 44%, respectively, while three-year OS rates were 29%, 4%, and 0%. Surgical intervention signi cantly in uenced OS (p<0.001). OS for surgical intervention was 28 months, and for inoperable cases, it was 12 months. One and three-year OS for surgical intervention were 95% and 11%, while for inoperable cases, they were 41% and 0%, respectively. Conclusion: Patients with gallbladder cancer, particularly in Bihar's Gangetic plains, face poor survival, especially with advanced disease. Adequate surgery improves outcomes, prompting a call for enhanced strategies, particularly for locally advanced GBC.

show abstract

Carcinoma of gall bladder: Demographic and clinicopathological profile in Indian patients

Cited by 8 publications

References 0 publications

Comprehensive review of current trends in adenocarcinoma of gall bladder in northern Indian region: An imperative clinico-histological approach

Comprehensive review of current trends in adenocarcinoma of gall bladder in northern Indian region: An imperative clinico-histological approach

Mortalidade por câncer de vesícula biliar no Estado de Sergipe e no Brasil, no período de 2009 a 2019 / Mortality from gallbladder cancer in the State of Sergipe and in Brazil, from 2009 to 2019

Prognostic Insights and Survival Analysis of Gallbladder Cancer in Bihar, India: a Prospective Observational Study Emphasizing the Impact of Surgical Intervention on Overall Survival

Contact Info

Product

Resources

About