Carcinoma of the bronchus presenting as renal failure secondary to amyloidosis

Garthwaite, Elizabeth A.; Sellars, L; Bhandari, Sunil

doi:10.1093/ndt/gfg063

Cited by 5 publications

(4 citation statements)

References 3 publications

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“…Amyloid A (AA) amyloidosis is a fatal systemic condition that occurs secondary to chronic inflammatory disorders such as rheumatoid arthritis (RA) [ 13 ], tuberculosis, syphilis, chronic pyelonephritis [ 5 ], inflammatory bowel disease [ 24 ], connective tissue diseases [ 22 ], and malignancies [ 9 , 17 ]. Persistently high concentrations of serum amyloid A (SAA) in the plasma are essential for the pathogenesis of AA amyloidosis [ 25 ].…”

mentioning

confidence: 99%

Variation of amino acid sequences of serum amyloid a (SAA) and immunohistochemical analysis of amyloid a (AA) in Japanese domestic cats

Tei

Uchida

Chambers

et al. 2018

The Journal of Veterinary Medical Science

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Amyloid A (AA) amyloidosis, a fatal systemic amyloid disease, occurs secondary to chronic inflammatory conditions in humans. Although persistently elevated serum amyloid A (SAA) levels are required for its pathogenesis, not all individuals with chronic inflammation necessarily develop AA amyloidosis. Furthermore, many diseases in cats are associated with the elevated production of SAA, whereas only a small number actually develop AA amyloidosis. We hypothesized that a genetic mutation in the SAA gene may strongly contribute to the pathogenesis of feline AA amyloidosis. In the present study, genomic DNA from four Japanese domestic cats (JDCs) with AA amyloidosis and from five without amyloidosis was analyzed using polymerase chain reaction (PCR) amplification and direct sequencing. We identified the novel variation combination of 45R-51A in the deduced amino acid sequences of four JDCs with amyloidosis and five without. However, there was no relationship between amino acid variations and the distribution of AA amyloid deposits, indicating that differences in SAA sequences do not contribute to the pathogenesis of AA amyloidosis. Immunohistochemical analysis using antisera against the three different parts of the feline SAA protein—i.e., the N-terminal, central, and C-terminal regions—revealed that feline AA contained the C-terminus, unlike human AA. These results indicate that the cleavage and degradation of the C-terminus are not essential for amyloid fibril formation in JDCs.

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confidence: 99%

Variation of amino acid sequences of serum amyloid a (SAA) and immunohistochemical analysis of amyloid a (AA) in Japanese domestic cats

Tei

Uchida

Chambers

et al. 2018

The Journal of Veterinary Medical Science

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“…17 A few cases of systemic amyloidosis (AA) have been seen in patients with NSCLC as well. 5,6 Currently, there is no scientific evidence establishing NSCLC and other malignancies as a factor in triggering ALECT2 amyloidosis but further exploration into this hypothesis might be fruitful.…”

Section: Discussionmentioning

confidence: 99%

“…Secondary amyloidosis (AA) occurs as a paraneoplastic syndrome in patients with renal cell carcinoma, and a few cases in patients with non-small cell lung carcinoma (NSCLC) have also been reported. 5,6 ALECT2 occurring in association with NSCLC has never been reported before, and currently, there is no scientific evidence linking the two. We report the autopsy findings of a 70-year-old Hispanic woman who died of metastatic adenocarcinoma of the lung and was incidentally found to have extensive amyloid deposition in her kidneys, liver, spleen, adrenal glands, small intestine, gallbladder, lungs, ovaries, and uterus at autopsy.…”

Section: Introductionmentioning

confidence: 97%

Leukocyte Cell-Derived Chemotaxin-2 Amyloidosis (ALECT2) in a Patient With Lung Adenocarcinoma: An Autopsy Report and Literature Review

Tariq

Sharkey

2017

Int J Surg Pathol

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Amyloidosis caused by deposition of leukocyte cell-derived chemotaxin-2 amyloidosis (ALECT2) is the most recently described form of systemic amyloidosis and has quickly emerged as a common and possibly underdiagnosed cause of slowly declining renal function, particularly in patients of Hispanic ancestry. We describe the autopsy findings in a 70-year-old Hispanic woman who died of metastatic lung adenocarcinoma and was incidentally found to have extensive amyloid deposition in the kidneys, liver, spleen, adrenal glands, small intestine, gallbladder, lungs, bilateral ovaries, and uterus. The type of amyloid was confirmed to be ALECT2 by mass spectrometry. The pattern of amyloid deposition in the kidneys and the liver was typical for what has been described for ALECT2. In addition, a unique pattern of amyloid deposition was observed in spleen, adrenal glands, small intestine, gallbladder, lungs, ovaries, and uterus. The pattern of amyloid deposition in ALECT2 is distinct from amyloid A and amyloid light-chain and needs to be recognized to avoid misdiagnosis as amyloid light-chain or amyloid A amyloidosis. After recognition, an accurate diagnosis by mass spectrometry and/or immunohistochemical staining is essential to guide treatment and avoid toxic therapies.

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“…This low incidence of malignancy-related systemic AA amyloidosis seems to be linked to the short-term survival of cancer patients who died before significant systemic deposition of amyloid fibrils can occur. Although the association between renal cell carcinoma and systemic AA amyloidosis has been established, the evidence linking pulmonary cancer to AA amyloidosis is scarce [ 2 , 5 – 7 ] and few reports concern mainly non small cell lung cancer and AA amyloidosis manifested by nephrotic syndrome [ 2 , 5 – 8 ]. We report here the case of nephrotic syndrome and renal failure due to systemic AA amyloidosis in a patient with nonsmall cell lung carcinoma (NSCLC).…”

Section: Introductionmentioning

confidence: 99%

Nephrotic Syndrome Associated with Lung Cancer: A Rare Case of Malignancy Associated with AA Amyloidosis

Gueutin

Langlois

Shehwaro

et al. 2013

Case Reports in Nephrology

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Carcinoma of the bronchus presenting as renal failure secondary to amyloidosis

Cited by 5 publications

References 3 publications

Variation of amino acid sequences of serum amyloid a (SAA) and immunohistochemical analysis of amyloid a (AA) in Japanese domestic cats

Variation of amino acid sequences of serum amyloid a (SAA) and immunohistochemical analysis of amyloid a (AA) in Japanese domestic cats

Leukocyte Cell-Derived Chemotaxin-2 Amyloidosis (ALECT2) in a Patient With Lung Adenocarcinoma: An Autopsy Report and Literature Review

Nephrotic Syndrome Associated with Lung Cancer: A Rare Case of Malignancy Associated with AA Amyloidosis

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