Carcinoma of the Female Breast: Conservative and Radical Surgery

Williams, I. G.; Murley, R. S.; Curwen, M. P.

doi:10.1136/bmj.2.4840.787

Cited by 83 publications

(14 citation statements)

References 5 publications

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“…Although limited in sample size, this was one of the first studies attempting to compare different local therapies in terms of objective outcomes. A retrospective study by Ivor G Williams (1907Williams ( -1989 in 1953 compared 10-year results for 1044 women treated with varying surgical approaches (simple excision, radical mastectomy, modified radical mastectomy and no surgery) with or without chest wall radiation at St Bartholomew's Hospital (London, UK) from 1930 to 1939 [22]. A subgroup of 505 patients were given either radical (n = 338) or modified radical (n = 167) mastectomy with or without radiation.…”

Section: Halstedian Eramentioning

confidence: 99%

A Historical Account of Breast Cancer Surgery: Beware of Local Recurrence but be not Radical

2014

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In the late 19th century, William Halsted proposed the radical mastectomy, which became the standard surgical treatment of breast cancer for nearly 100 years. Later in this period, theories suggesting that breast cancer was a systemic disease at inception were championed by Bernard Fisher. This alternative hypothesis of biological predeterminism was based upon results of randomized clinical trials comparing breast conserving therapy with mastectomy, which showed similar overall survival outcomes. Nonetheless, data from meta-analyses suggest that inadequate local therapy can increase risk of local recurrence, which can subsequently increase mortality. In this review, the authors provide an historical account of how local therapy of breast cancer has evolved in the face of improved adjuvant therapies and better understanding of disease biology.

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Section: Halstedian Eramentioning

confidence: 99%

A Historical Account of Breast Cancer Surgery: Beware of Local Recurrence but be not Radical

2014

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“…Because of the rudimentary external beam radiation equipment available at that time, Keynes treated patients by radium needle implantation of the breast and draining lymph node areas. A lO-year retrospective review from St. Bartholomew'S Hospital was published in 1953 (17). For patients with disease clinically confi ned to the breast, the lO-year survival rate following simple surgery and radium treatment was 49%, compared to 52% for radical surgery.…”

Section: Primary Radiation Therapymentioning

confidence: 99%

Primary Radiation Therapy for Breast Cancer

Harris¹,

Levene²,

Hellman³

1981

Annu. Rev. Med.

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“…[1][2][3][4][5][6][7][8][9] Since this proposition is completely contrary to standard concepts about cancer, it appeared worthwhile for us to study our own results. Essentially this paper is a review of what has happened to a relatively uniform group of patients in different age series.…”

Section: Introductionmentioning

confidence: 99%