Carcinoma of the ileum occurring in an area of regional enteritis

Buchanan, David P.; Huebner, Gilbert D.; Woolvin, Samuel C.; North, Robert L.; Novack, Tevor D.

doi:10.1016/0002-9610(59)90313-7

Cited by 36 publications

(3 citation statements)

References 2 publications

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“…So far as carcinoma of the small intestine is concerned we have found a number of individual case reports (Bersack et al, 1958;Buchanan et al, 1959;Ginzburg et al, 1956;Kornfeld et al, 1957;Weingarten et al, 1959;Weingarten and Weiss, 1960;Zisk et al, 1960). In nearly all these cases the Crohn's disease had been diagnosed several years before the occurrence of the carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Crohn's disease and carcinoma of colon.

Perrett¹,

Truelove²,

Massarella³

1968

BMJ

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[WITH SPECIAL PLATE BETWEEN PAGES 466 AND 467] Brit. med. J., 1968, 2, 466-468 In a recent survey of Crohn's disease undertaken at the Radcliffe Infirmary three cases were encountered in which both carcinoma of the colon and Crohn's disease were present. As it is generally held that there is no association between these two diseases it seems important to report these cases and to discuss the possibility that a genuine association exists. Investigations.-Haemoglobin 7.2 g./100 ml. Blood filmmarked iron-deficiency changes. Stools-repeatedly positive for occult blood, negative for pathogens, no acid-fast bacilli on culture. Barium enema showed an irregular filling defect of the caecum, together with narrowing of a short segment of the pelvic colon.At operation in November 1949 the appearances were those of a malignant lesion of the caecum, to which the sigmoid colon and coils of terminal ileum were adherent. A right hemicolectomy, ileal resection, and sigmoid resection was carried out, with end-toend anastomosis of the left colon, and end-to-side ileotransverse colostomy.The caecum contained a large soft carcinoma which had partially infiltrated the caecal wall. There were adhesions between caecum and overlying loops of ileum. Histologically the tumour was a moderately differentiated papillary adenocarcinoma. Microscopically, some adhesions were inflammatory in nature and others were neoplastic. A mixed inflammatory infiltrate within the caecum extended well beyond the limits of the tumour, and within this infiltrate were granulomatous foci containing giant cells. There were marked submucosal fibrous thickening and fibrous infiltration of pericolic fat, and fissures were present. Within the ileum there was again pronounced subserosal and submucosal fibrous thickening, and the submucosa contained patchy mixed inflammatory infiltrate, including moderate numbers of giant cells. Enlarged mesenteric lymph nodes showed marked reactive hyperplasia but no evidence of malignancy. In summary the changes were typical of Crohn's disease involving the caecum and ileum.After the operation the patient developed a faecal fistula from the sigmoid resection site, but this eventually closed and she was discharged home three months after admission. She was readmitted four months later because the fistula had recurred. This was excised and the defect in the colon closed. She remained well for seven years.She was admitted again in 1957 and an intraperitoneal abscess adjacent to the ileocolic anastomosis was drained. Numerous adhesions were divided at the time. She had persistent diarrhoea after this operation and was readmitted a few months later with a fistula-in-ano, a fissure-in-ano, and an ischiorectal abscess. These were dealt with surgically and she was discharged considerably improved.She was next admitted in November 1958 with a small-intestinal obstruction. Laparotomy revealed a mass at the site of the ileocolic

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Section: Discussionmentioning

confidence: 99%

Crohn's disease and carcinoma of colon.

Perrett¹,

Truelove²,

Massarella³

1968

BMJ

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“…For many years, the only published evidence for an association between CD and cancer came from case reports. [3][4][5][6][7][8][9] The first epidemiologic study reporting risk ratios for cancer in patients with CD compared with the background population was published by the Mayo Clinic in 1973. 10 In this particular study, the relative risk of developing colorectal cancer was more than 20 times greater in patients with CD compared with the background population.…”

mentioning

confidence: 99%

The Risk of Cancer in Patients with Crohn's Disease

Roon¹,

Reese²,

Teare³

et al. 2007

Diseases of the Colon &Amp; Rectum

286

166

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“…The risk of developing cancer in patients with Crohn's disease, in fact, was subject of controversy since 1948, when Warren and Sommers reported the case of a colorectal carcinoma arising in a patient with Crohn's disease (Warren & Sommers, 1948). The testimony of some association between Crohn's disease and cancer remained for many years related to description of single case reports (Ginzburg et al, 1956;Buchanan et al, 1959;Zisk et al, 1960;Hoffert et al, 1963;Berman et al, 1964;Cantwell et al, 1968), until in 1973 published an epidemiological study on the risk of cancer in patients with Crohn's disease compared with that of the general population (Weedon et al, 1973). While the evidence of an increased risk of colorectal cancer in patients with ulcerative colitis is yet another further confirmation in recent study (Eaden JA.…”

Section: Crohn's Disease and Cancer: Historymentioning

confidence: 99%