Carcinoma of the kidney arising in the glomeruli

Abram, John Hill

doi:10.1002/path.1700060311

J. Pathol.

1900

DOI: 10.1002/path.1700060311

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Carcinoma of the kidney arising in the glomeruli

John Hill Abram¹

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2004

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An Immunophenotypic Comparison of Metanephric Metaplasia of Bowman Capsular Epithelium With Metanephric Adenoma, Wilms Tumor, and Renal Development : A Case Report and Review of the Literature

Fischer¹,

Carney²,

Anderson³

et al. 2004

American Journal of Clinical Pathology

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Metanephric metaplasia of the parietal epithelium of the Bowman capsule is a rare pathologic finding of unknown pathogenesis that has occurred in patients with widespread malignant neoplasms of various types. We report this finding in a 25-year-old woman with partial expression of the Carney triad who died of a disseminated gastrointestinal stromal tumor, specifically a gastric stromal sarcoma. The metaplasia involved both kidneys diffusely. It originated in the parietal epithelium of the Bowman capsule, extended into the proximal tubules, and focally surrounded the glomeruli in a semicircular manner Immunohistochemical analysis revealed that the cells of metanephric metaplasia expressed the Wilms tumor gene product, bcl-2 protein, and CD57 and cytokeratin 7 and keratin AE1/AE3 focally, but not CD56. This immunophenotype parallels that of metanephric adenoma, Wilms tumor, and nephrogenic rests and overlaps with antigen expression in certain periods of renal development.

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An Immunophenotypic Comparison of Metanephric Metaplasia of Bowman Capsular Epithelium With Metanephric Adenoma, Wilms Tumor, and Renal Development : A Case Report and Review of the Literature

Fischer¹,

Carney²,

Anderson³

et al. 2004

American Journal of Clinical Pathology

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show abstract

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Carcinoma of the kidney arising in the glomeruli

Cited by 1 publication

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An Immunophenotypic Comparison of Metanephric Metaplasia of Bowman Capsular Epithelium With Metanephric Adenoma, Wilms Tumor, and Renal Development : A Case Report and Review of the Literature

An Immunophenotypic Comparison of Metanephric Metaplasia of Bowman Capsular Epithelium With Metanephric Adenoma, Wilms Tumor, and Renal Development : A Case Report and Review of the Literature

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