Carcinoma of the oral tongue in patients younger than 30 years: Comparison with patients older than 60 years

Hilly, Ohad; Shkedy, Yotam; Hod, Roy; Soudry, Ethan; Mizrachi, Aviram; Hamzany, Yaniv; Bachar, Gideon; Shpitzer, Thomas

doi:10.1016/j.oraloncology.2013.07.005

Cited by 79 publications

(116 citation statements)

References 30 publications

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“…Other studies revealed that the prognostic disadvantage of young age may be limited to individuals with advanced, as opposed to early, disease at presentation (12) or with recurrent, as opposed to new-onset, disease (13). Accordingly, we previously reported that tongue carcinoma in patients <30 years old is more advanced at presentation, with significantly high rates of regional metastases and an increased risk of distant failure compared with patients >30 years (14). In addition, recurrent disease is aggressive, with a fatality rate of 100% (14).…”

Section: Introductionmentioning

confidence: 99%

“…Accordingly, we previously reported that tongue carcinoma in patients <30 years old is more advanced at presentation, with significantly high rates of regional metastases and an increased risk of distant failure compared with patients >30 years (14). In addition, recurrent disease is aggressive, with a fatality rate of 100% (14). However, other authors noticed that clinical outcomes in young patients were similar to (15–18) or even better than (19–21) those in older patients.…”

Section: Introductionmentioning

confidence: 99%

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Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients

et al. 2016

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Oral cavity squamous cell carcinoma may be more aggressive at presentation and recurrence in young patients compared with older patients. Dysregulation of microRNAs (miRNAs or miRs) has been associated with the development and prognosis of oral cavity cancer. The present study investigated miRNA expression in carcinoma of the oral tongue in young patients. miRNA expression profiles were evaluated in formalin-fixed, paraffin-embedded samples of tumor and normal mucosa from 12 patients aged <30 years old with squamous cell carcinoma of the tongue. The levels of let-7f-5p, miR-30b-5p and let-7e-5p were upregulated in tumors (P<0.05). The expression of let-7f-5p was upregulated in non-aggressive tumors, while the expression of let-7e-5p was upregulated in aggressive tumors, compared with the corresponding normal tissue. Aggressive tumors had higher levels of let-7c, miR-130a-3p, miR-361-5p, miR-99a-5p, miR-29c-3p and let-7d-5p than non-aggressive tumors (P<0.05). The findings remained significant for let-7c upon false-discovery rate correction. An excellent correlation was noticed on validation of NanoString counts by quantitative polymerase chain reaction. The comparison with published findings in adults demonstrated a unique miRNA signature in young patients with aggressive disease. Aggressive oral cavity cancer in patients <30 years old is associated with a distinctive expression pattern of the let-7 family. Larger studies including direct comparison with older patients are warranted.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients

et al. 2016

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“…Although presented with malignancy at this late period of life, they were said to have less rates of regional metastases and distant failure. Recurrent disease, should it occur, is also less aggressive comparing to patients aged younger than 30 years 6 . Cigarette smoking and alcohol consumption are the two strongest etiological factors in the development of tongue SCC.…”

Section: Discussionmentioning

confidence: 99%

Tackling Squamous Cell Carcinoma of Tongue in a 76 Year Old Man: A Case Report

Shaeran

Rahman

Pohchi

et al. 2015

Bangladesh J Med Sci

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“…L'évolution clinique se démarque du carcinome épidermoïde de l'adulte avec une tendance à l'invasion métastatique significativement plus élevée même si on ne retrouve pas de différence au niveau des grades histologiques [5,6]. Le pronostic est beaucoup plus sombre chez les moins de 30 ans avec, en cas de récidive, 100 % de décès à 16 mois [7] contre 12 à 50 % de survie à 5 ans selon les études chez l'adulte plus âgé [8].…”

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Découverte d’un carcinome épidermoïde du trigone rétromolaire chez un jeune adulte sans facteurs de risque

Benhamou

Raybaud

Poissonnet

et al. 2014

Med Buccale Chir Buccale

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Résumé -Introduction :Le carcinome épidermoïde oral est habituellement diagnostiqué chez des patients alcoolo-tabagiques entre 50 et 60 ans. Des cas de carcinomes épidermoïdes oraux sont de plus en plus rapportés chez des patients jeunes sans facteurs de risques habituels, entrainant une errance diagnostique et un mauvais pronostic. Observation : Le diagnostic tardif d'un carcinome épidermoïde mandibulaire survenu chez un jeune patient de 27 ans sans facteurs de risque est rapporté. En dépit d'un traitement chirurgical, d'une chimiothérapie ciblée, et d'une radiothérapie, le patient n'a pas survécu. Discussion : L'interprétation des informations cliniques pourrait aider à comprendre ce qui provoque l'apparition prématurée de ces cancers et leur agressivité.Abstract -Discovery of squamous cell carcinoma of the retromolar trigone in a young adult without risk factors. Introduction: Oral squamous cell carcinoma (OSCC) is usually diagnosed in a context of alcohol and tobacco intoxication in patients between 50 and 60 years of age. Cases of OSCC are increasingly found in young patients without any of the usual risk factors, resulting in diagnostic uncertainty and poor prognosis. Case report: This article reports a case of late diagnosis of mandibular OSCC in a young 27-year-old male patient with no risk factors. Despite surgical treatment combined with targeted chemotherapy and radiotherapy, the patient did not survive. Discussion: Interpretation of clinical data might help in understanding what underlies early development of these cancers and their aggressiveness.

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Carcinoma of the oral tongue in patients younger than 30 years: Comparison with patients older than 60 years

Cited by 79 publications

References 30 publications

Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients

Distinctive pattern of let-7 family microRNAs in aggressive carcinoma of the oral tongue in young patients

Tackling Squamous Cell Carcinoma of Tongue in a 76 Year Old Man: A Case Report

Découverte d’un carcinome épidermoïde du trigone rétromolaire chez un jeune adulte sans facteurs de risque

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