Carcinoma of the pancreas

Levison, David A.

doi:10.1002/path.1711290406

Cited by 34 publications

(3 citation statements)

References 87 publications

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“…In reviewing carcinoma of the pancreas in 1979, Levison postulated that a diet rich in fat and protein may promote growth of the pancreas through the gut hormone cholecystokinin (CCK), and thus sensitize the pancreas to the action of (precursors of) environmental carcinogens derived from the d.iet (Levison, 1979). CCK was reported to enhance nitrosamine-induced pancreatic carcinogenesis in hamsters (Howatson and Carter, 1985).…”

Section: Discussionmentioning

confidence: 99%

“…Although one study reported a positive association with chronic constipation (Howson and Asal, 1976). it was postulated that frequent, loose stools may be positively related to risk mediated by the gut hormone CCK which increases bowel motility (Christensen, 1987) and is thought to play a role in pancreatic carcinogcnesis (Levison, 1979;Howatson and Carter, 1985). A history of tonsillectomy was shown to be related to decreased risk (Gold et al, 1985).…”

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confidence: 99%

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Aspects of medical history and exocrine carcinoma of the pancreas: A population‐based case‐control study in The Netherlands

Mesquita

Maisonneuve

Moerman

et al. 1992

Intl Journal of Cancer

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During 1984-88 a population-based case-control study was carried out in The Netherlands, in collaboration with the International Agency for Research on Cancer, to examine the possible relationship between aspects of medical history and exocrine pancreatic carcinoma in 176 cases and 487 controls. About 58% of patients were interviewed directly. We observed an inverse relationship between medical treatment for allergy-related conditions and the development of pancreatic cancer (30 cases vs. 130 controls, OR 0.57, 95% CI 0.36 to 0.90). A history of gallbladder problems, gallstones, cholecystectomy, stomach or duodenal ulcer, pancreatitis, appendicitis, diabetes or tonsillectomy was not related to risk. In direct responses, compared with once daily, a positive relationship was seen for stool frequency, 10 years ago, of less than once daily (18 cases vs. 40 controls, OR 2.10, 95% CI 1.09 to 4.04). In men, diabetes treated with insulin and diagnosed more than 1 year previously was significantly and positively related to risk (5 cases vs. 1 control, OR 11.66, 95% 1.28 to 105.95). In brief, the results of the present study suggest that a history of allergy-related conditions may protect, whereas a past stool frequency of less than once daily may enhance the risk of cancer of the pancreas. Other elements of the medical history were not consistently related to risk.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Aspects of medical history and exocrine carcinoma of the pancreas: A population‐based case‐control study in The Netherlands

Mesquita

Maisonneuve

Moerman

et al. 1992

Intl Journal of Cancer

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“…There were seven deaths from cancer of the stomach with 3 2 expected, a statistically significant increase. The analysis was repeated for the causes of death of interest according to the duration of follow up (table 6). At Bilston the SMR was significantly raised for all cancers and for cancer of the pancreas with five of the six deaths occurring in those with a follow up of over 20 years.…”

Section: Simulation Testsmentioning

confidence: 99%

Mortality of workers at acetylene production plants.

Newhouse

Matthews

Sheikh

et al. 1988

Occupational and Environmental Medicine

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To reduce the risk of explosion oxyacetylene cylinders are filled with a spongy mass, acetone is added to saturate the mass, and acetylene is pumped into the cylinder. The first cylinders manufactured before 1936 By the late 1970s the stock of kapok cylinders was less than 10% of all cylinders in circulation. Kapok cylinders at present account for less than 5% of the total DA cylinder stock.DA cylinders had to be examined by law annually to ensure that the mass was in sound condition. The methods of examining kapok cylinders varied between three successive periods. During the first period, which lasted from the time of first manufacture up to about 1939, the thimble and blue asbestos were removed and the kapok examined; about 16 oz of asbestos and the thimble were then replaced. The second period was between 1939 and 1972. Owing to settling of the cylinder packing the practice was to remove the thimble, top up with a small amount of asbestos if necessary, without removing the old asbestos, and then to replace the thimble and valve. A search for a material to replace crocidolite asbestos began in 1969. Sisal was finally chosen and since January 1972 has been put over the crocidolite as required. All topping up with crocidolite ceased and stores of crocidolite asbestos were disposed of. Between 1972 and 1975 no removal of any material took place.In 1975 and 1976 the metal thimbles were replaced with felt plug filters and every kapok cylinder examined had a thick pad of sisal put over the crocidolite. 63

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Concomitant neoplasia in pancreatic cancer

Hartveit

Mæhle

1982

Cancer

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An association is reported between endocrine tumors and adenocarcinoma of the exocrine pancreas. This became apparent in autopsy material from Hordaland County, Norway, between 1972‐1976, but had not been seen in the preceding 15 years. It was accompanied by an increase in multiple primary cancers. On the basis of the findings in the case‐matched controls, it is concluded that the increases recorded in this autopsy material are real.

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Carcinoma of the pancreas

Cited by 34 publications

References 87 publications

Aspects of medical history and exocrine carcinoma of the pancreas: A population‐based case‐control study in The Netherlands

Aspects of medical history and exocrine carcinoma of the pancreas: A population‐based case‐control study in The Netherlands

Mortality of workers at acetylene production plants.

Concomitant neoplasia in pancreatic cancer

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