Carcinoma of the vulva: Analysis of treatment failures

Podratz, Karl C.; Symmonds, Richard E.; Taylor, William F.

doi:10.1016/0002-9378(82)90823-7

Cited by 175 publications

(123 citation statements)

References 13 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…All patients in this study with FIGO stage III/IV had positive lymph nodes. This is in accordance with others who also found positive lymph nodes as a predictive factor [21,32,33]. The primary route of spread in vulvar cancer is by lymphatic embolization to the regional inguinofemoral lymph nodes.…”

Section: Discussionsupporting

confidence: 92%

Patterns and frequency of recurrences of squamous cell carcinoma of the vulva

Woolderink

Bock

Hullu

et al. 2006

Gynecologic Oncology

View full text Add to dashboard Cite

Objective. To analyze patterns and frequency of recurrences of squamous cell carcinoma (SCC) of the vulva after wide local excision (WLE) and superficial inguinal lymphadenectomy with separate incisions and to identify prognostic factors for the development of recurrences.Methods. Between January 1985 and December 1999, all 125 consecutive patients with primary SCC of the vulva, treated with WLE and superficial inguinal lymphadenectomy, were retrospectively analyzed. Recurrences were registered by localization as: local, skin bridge, groin or distant.Results. A local recurrence was diagnosed in 29 (23%) patients, 11 (9%) developed a groin and 4 (3%) a distant recurrence. No skin bridge recurrences were identified. The 5 years local relapse-free survival was 70%. After a first local recurrence, 72% of these patients developed a second local recurrence. Adjusted for other predictors, older age (>74 years) is an independent risk factor for local recurrences (HR: 2.38; 95%-C. I.: 1.08-5.23) and stage III/IV cancer for developing groin/distant recurrences (HR: 3.03; 95%-C.I.: 1.0-9.18).Conclusion. WLE and superficial inguinal lymphadenectomy with separate incisions result in a high groin recurrence rate in this study; superficial lymphadenectomy should be replaced by deep inguinofemoral lymphadenectomy. After a local recurrence, 72% of the patients developed a second local recurrence. These patients are at high risk and need a close follow-up.

show abstract

Section: Discussionsupporting

confidence: 92%

Patterns and frequency of recurrences of squamous cell carcinoma of the vulva

Woolderink

Bock

Hullu

et al. 2006

Gynecologic Oncology

View full text Add to dashboard Cite

show abstract

“…Potential risk factors for vulvar rancer recurrences include stage, tumour size, depth of invasion, tumor free margin, lymphovascular space invasion, age and nodal involvement. Althought the importance of these risk factors is inconclusive and varies across the studies (Andreasson et al, 1985;Podratz et al, 1983;Hefler et al, 1999;Chan et al, 2007). …”

Section: Discussionmentioning

confidence: 99%

Midline Involvement as a Risk Factor for Vulvar Cancer Recurrence

Stankeviča

Macuks²,

Baidekalna³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…Debilitating lymphedema is a longterm problem affecting the lower extremities; in a study by Podratz et al, this was reported to be the case in 69% of their radical vulvectomy patients [14]. Other complications reported include lymphocyst development and p arasthesia over the medial thigh.…”

Section: Surgical Morbiditymentioning

confidence: 99%

State of the Art of Sentinel Lymph Node Biopsy in Vulvar Carcinoma

McGee

Covens

2009

Womens Health (Lond Engl)

View full text Add to dashboard Cite

Treatment for early-stage vulvar carcinoma has evolved from radical en bloc dissection to wide local incision with lymphadenectomy through separate groin incisions, to sentinel lymph node biopsy (SLNB). The morbidity of SLNB is far less than traditional inguinofemoral lymphadenectomy, with less lymphedema and sensory deficit, shorter hospital stays and fewer infections. A multidisciplinary approach is required, with success of the SLNB technique maximized when radiolabeled colloid is used, with blue dye added when further identification is needed. Frozen-section analysis, followed by ultrastaging of the nodal sample, minimizes the need for reoperations and decreases the risk of false negatives. We believe that SLNB will become the standard of care for treatment of early-stage vulvar carcinoma.

show abstract

Carcinoma of the vulva: Analysis of treatment failures

Cited by 175 publications

References 13 publications

Patterns and frequency of recurrences of squamous cell carcinoma of the vulva

Patterns and frequency of recurrences of squamous cell carcinoma of the vulva

Midline Involvement as a Risk Factor for Vulvar Cancer Recurrence

State of the Art of Sentinel Lymph Node Biopsy in Vulvar Carcinoma

Contact Info

Product

Resources

About