Carcinome épidermoïde de la tête et du cou dans une population ougandaise: étude épidémiologique descriptive

Kakande, Emily; Byaruhaga, R.; Kamulegeya, Adriane

doi:10.1007/s12558-010-0116-y

Cited by 5 publications

(8 citation statements)

References 41 publications

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“…This was consistent with other studies [21] but different from others [9, 11, 14]. The possibility of misclassification of original OSCC site is high given the complex anatomy of the oral cavity coupled with delayed presentation seen among our patients [22]. In advanced stages, there could be an overlap of oral tumours that arise from adjacent structures leading to misclassification.…”

Section: Discussionsupporting

confidence: 90%

Survival and associated factors among patients with oral squamous cell carcinoma (OSCC) in Mulago hospital, Kampala, Uganda

2018

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Background Despite improvements in diagnosis and patient management, survival and prognostic factors of patients with oral squamous cell carcinoma (OSCC) remains largely unknown in most of Sub Saharan Africa. Objective To establish survival and associated factors among patients with oral squamous cell carcinoma treated at Mulago Hospital Complex, Kampala. Methods We conducted a retrospective cohort study among histologically confirmed oral squamous cell carcinoma (OSCC) patients seen at our centre from January 1st 2002 to December 31st 2011. Survival was analysed using Kaplan-Meier method and comparison between associated variables made using Log rank-test. Cox proportional hazards model was used to determine independent predictors of survival. P -values of less than 0.05 were considered statistically significant. Results A total of 384 patients (229 males and 155 females) were included in this analysis. The overall mean age was 55.2 (SD 4.1) years. The 384 patients studied contributed a total of 399.17 person-years of follow-up. 111 deaths were observed, giving an overall death rate of 27.81 per 100 person-years [95% CI; 22.97–32.65]. The two-year and five-year survival rates were 43.6% (135/384) and 20.7% (50/384), respectively. Tumours arising from the lip had the best five-year survival rate (100%), while tumours arising from the floor of the mouth, alveolus and the gingiva had the worst prognosis with five-year survival rates of 0%, 0% and 15.9%, respectively. Independent predictors of survival were clinical stage ( p = 0.001), poorly differentiated histo-pathological grade ( p < 0.001), male gender (p = 0.001), age > 55 years at time of diagnosis ( p = 0.02) and moderately differentiated histo-pathological grade ( p = 0.027). However, tobacco & alcohol consumption, tumour location and treatment group were not associated with survival ( p > 0.05). Conclusions The five-year survival rate of OSCC was poor at 20.7%. Male gender, late clinical stage at presentation, poor histo-pathological types and advanced age were independent prognostic factors of survival. Early detection through screening and prompt treatment could improve survival.

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Section: Discussionsupporting

confidence: 90%

Survival and associated factors among patients with oral squamous cell carcinoma (OSCC) in Mulago hospital, Kampala, Uganda

2018

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“…This is similar to an earlier study done in Uganda so no change in age distribution [25]. As expected due to matching on age and gender, there was neither statistically significant difference between male and female distribution nor between HIV positive and negative patients as per age groups (P=0.09 χ 2 10.7 df 6) (p=0.97 χ 2 =1.23 df 6) respectively.…”

Section: Discussionsupporting

confidence: 89%

“…As expected due to matching on age and gender, there was neither statistically significant difference between male and female distribution nor between HIV positive and negative patients as per age groups (P=0.09 χ 2 10.7 df 6) (p=0.97 χ 2 =1.23 df 6) respectively. The combined male to female ratio was 1.7:1 in contrast with 1.3:1 in an earlier study [25] but close to what was reported from Egypt [26]. However, the ratio is lower than what has been reported from most developed countries [27].…”

Section: Discussionsupporting

confidence: 76%

Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample

Kamulegeya

Otiti

2017

IJCOMS

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Increased availability of highly active anti-retroviral therapy (HAART) has led to a change in the spectrum of neoplastic diseases affecting people living with HIV. Some cancers such as invasive cervical carcinoma and anal cancers have not changed or instead risen while others such as Kaporsi's sarcoma have seen a sharp decline. The aim of this study was to compare clinical findings at presentation between HIV positive and Negative patients with head and neck cancers using a retrospective case control design. The study was done at the Uganda cancer Institute by performing a manual match of records in the head and neck cancer database at a ratio of 1:2 cases: controls. The matching was done on the age group, gender and diagnosis. Clinical and demographic characteristics between HIV positive and HIV negative head and neck cancer patients were compared using chi square and a multinomial model including ECOG performance score, stage, grade and duration group was run. In the multinomial regression only duration group was significant with the HIV positive patients being more likely to present after a longer duration of the symptoms than HIV negative patients (OR=0.42 CI 0.20-0.86 p=0.02). The data does not show statistically significant difference between HIV positive and HIV negative head and neck cancer patients in terms of presentation at time of diagnosis except for duration of symptoms group. This study clearly demonstrates the need for more research on head and neck cancer in Africa in the context of HIV/AIDS, since the reasons for the high HIV prevalence among this cohort of patients hasn't been established.

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“…The commonest histological type is squamous cell carcinoma (SCC) accounting for more than 90% of HNC [2]. Globally and locally, more than half of these cancers arise from the oral cavity/ oropharynx [1,3].…”

Section: Introductionmentioning

confidence: 99%

A descriptive study of human papilloma virus in upper aero-digestive squamous cell carcinoma at Uganda cancer institute assessed by P16 immunohistochemistry

et al. 2020

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Background: Cancer burden in sub-Saharan Africa is on the rise with one-third of cancers estimated to be caused by infectious agents. Head and neck squamous cell cancer (HNSCC) is the sixth most common malignancy in sub-Saharan Africa and includes tumors in the Upper Aero-digestive Tract (UADT). The established risk factors are tobacco and alcohol exposure with a recent recognition of the role of Human Papilloma Virus (HPV). The HPV related HNC is seen predominantly in the oropharynx, presents at a younger age and has a better prognosis. With a rapidly increasing incidence of these cancers in the developed world, it was important to study HPV in HNC in Uganda. The HPV can be detected using P16 immunohistochemistry as a surrogate marker thus making it suitable for screening. The study aimed at establishing the presence of HPV and the commonly affected sites in UADT squamous cell carcinoma (SCC) at Uganda Cancer Institute (UCI) using P16 immunohistochemistry. Methodology: This was a cross sectional study in which 59 patients with histologically proven SCC from the oral cavity, oropharynx, larynx and hypopharynx were recruited. These patients' demographics and clinical data were collected. Tissue sections from retrieved histology samples were stained by Haematoxylin and Eosin to reconfirm SCC. Subsequently, P16 expression was determined using P16 immunohistochemistry. Results: Seventy-one patients were enrolled and 59 patients with confirmed SCC of the sites of interest were analyzed. The majority (79.7%) of the participants were male and over 50 years. 59.3% were tobacco smokers, 66.1% used alcohol, 52.2% used both. Only 27.1% used none of the substances. Only 27.1% of the participants were HIV positive. Most of the tumors were in the larynx (37.3%) and 64.4% were overall TNM stage 4. The overall prevalence of HPV in UADT SCC at UCI was 20.3, 95%CI 10.9-32.8. The oropharynx had the highest prevalence (30.8%). Conclusion: The prevalence of HPV in UADT SCC at UCI is significant at 20.3%. The most affected site, is the oropharynx. Vigilant HPV screening of these sites with confirmation where possible is recommended.

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Carcinome épidermoïde de la tête et du cou dans une population ougandaise: étude épidémiologique descriptive

Cited by 5 publications

References 41 publications

Survival and associated factors among patients with oral squamous cell carcinoma (OSCC) in Mulago hospital, Kampala, Uganda

Survival and associated factors among patients with oral squamous cell carcinoma (OSCC) in Mulago hospital, Kampala, Uganda

Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample

A descriptive study of human papilloma virus in upper aero-digestive squamous cell carcinoma at Uganda cancer institute assessed by P16 immunohistochemistry

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