Carcinosarcoma of lung associated with asbestosis

Farrell, D J; Cooper, P.; Malcolm, A. J.

doi:10.1111/j.1365-2559.1995.tb00317.x

Cited by 19 publications

(10 citation statements)

References 3 publications

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“…Chondroid metaplasia is also sometimes seen in the stroma next to a carcinoma. The tumors that contain heterologous cartilaginous elements usually occur in the female genital tract, but now they have been documented in many other organs as well, such as the lung, 9 liver, 10 prostate, 11 and breast. The nosological concept is equally debated between various authors.…”

Section: Discussionmentioning

confidence: 99%

“…These tumors have received a variety of appellations, such as mixed mullerian (mesodermal) tumors when seen in the female genital tract, 7,8 but carcinosarcomas when they occur in the lung, liver or prostate. [9][10][11] Neoplasms of the breast that are identical to these tumors are not usually designated as carcinosarcomas, but rather are referred to as metaplastic carcinomas.…”

Section: Discussionmentioning

confidence: 99%

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Sarcomatoid Carcinoma of the Stomach with Heterologous Elements

Khan

1999

Ann Saudi Med

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We report a unique sarcomatoid carcinoma of the stomach that, in addition to having carcinomatous and sarcomatous components, also contained foci of heterologous cartilaginous differentiation. Gastric sarcomatoid carcinomas were reviewed by Iezzoni and Mills, but cartilaginous differentiation was not seen in any of their 30 cases.1 Robey-Cafferty and associates have also reported three cases, but none of them contained heterologous cartilaginous elements.2 One case report from Korea, however, mentions the presence of cartilage in a carcinosarcoma of the stomach. Case ReportA 46-year-old Saudi man was admitted to Asir Central Hospital with recent onset of dyspepsia, anorexia and weight loss. An endoscopic examination of the stomach was performed and a biopsy was taken. This initial biopsy was unsuccessful in demonstrating the tumor. On explorative laparotomy, however, a large tumor was found, necessitating total gastrectomy and splenectomy.The gastrectomy specimen measured 22 cm in length and 9 cm in diameter across the body of the stomach. When the stomach was opened along the greater curvature, a large ulcer was noted in the antral region, measuring 4x3 cm. The margins of the ulcer were edematous and elevated, with loss of mucosal rugosities around its circumference. The wall of the stomach beneath the ulcerated lesion was thickened (2.5 cm), with grayish-white homogeneous cut surfaces. Six lymph nodes were found along the greater curvature of the stomach, ranging in size from 0.4 to 0.9 cm in maximal dimension. The spleen measured 10x5.5x4 cm, and was grossly unremarkable. Microscopically, the ulcerated lesion of the stomach showed a biphasic tumor invading the full thickness of its wall. The tumor was composed of two distinct components, one being a moderately differentiated adenocarcinoma and the other being a sarcoma (Figure 1).The carcinomatous component consisted of irregular glands that were lined by stratified columnar cells containing hyperchromatic nuclei. These neoplastic glands were separated from each other by a sarcomatous stroma of pleomorphic spindle-shaped cells exhibiting frequent mitotic figures. There were clear-cut foci of chondroid differentiation among the sarcomatous elements, exhibiting significant nuclear atypia. Transition between carcinomatous and sarcomatous components was not seen, but the sarcomatous foci merged imperceptibly with cartilaginous foci. The tumor invaded deeply in the muscularis propria. A random section taken at a distance from the main tumor displayed foci of intestinal metaplasia and dysplasia. Gastric margins of resection, the lymph nodes and spleen were not involved by the tumor. DiscussionChondroid differentiation is rare in sarcomatoid carcinomas of the stomach, but it is not uncommon in those tumors that arise from the esophagus, small intestine 1 and colon. 5 In the 30 cases reviewed by Iezzoni and Mills, 1 the average age of the patients with gastric sarcomatoid carcinoma was 52 years, and 64% were males. These tumors arose from all portions of the stomach...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sarcomatoid Carcinoma of the Stomach with Heterologous Elements

Khan

1999

Ann Saudi Med

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“…In our study, the male-female ratio was actually 18:1, but this could possibly be attributed to lower smoking rates of females in our country. [14] Although a very few reports associated asbestos with PC, the primary factor in many patients is smoking, [3,15] with most PC patients being heavy smokers. [3,16] Fishback et al [3] also reported that their patients had a diagnostic age of 62 years; while Mochizuki et al [13] determined that theirs had a diagnostic age of 67 years.…”

Section: Subgroupmentioning

confidence: 99%

Clinical characteristics and prognosis of pulmonary pleomorphic carcinoma: retrospective analysis of 57 patients

Aydin¹

2015

Turk Gogus Kalp Dama

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Bu çalışmada pulmoner pleomorfik karsinomun klinik özellikleri ve prognozu değerlendirildi. Ça lış ma pla nı: Çalışmaya pleomorfik karsinom nedeni ile ameliyat edilen 57 hasta (54 erkek, 3 kadın; ort. yaş 60.4 yıl; dağılım 33-75 yıl) dahil edildi. Kliniğimizde 1999-2009 yılları arasında pleomorfik karsinom tanısıyla opere edilen hastalar çalışmaya alındı. Tüm veriler hasta dosyalarından retrospektif olarak kaydedildi. Bul gu lar: Hastaların 54'ü sigara içmekte (ortalama 49.9 paket/yıl) idi. En yaygın semptomlar hemoptizi ve öksürük idi ve 51 hasta asemptomatik idi. Tüm hastaların tanısı pleomorfik karsinom olarak ameliyat sonrası doğrulandı. Uygulanan cerrahi yaklaşımlar beş parenkim koruyucu rezeksiyon, 35 lobektomi, yedi bilobektomi ve bir torakoskopik biyopsi idi. Epitelyal komponentlerin 28'i adenokarsinom, 15'i epidermoid karsinom, altısı büyük hücreli karsinom iken, sarkomatoid komponentlerin 28'inde iğsi hücreler, 22'sinde dev hücreler, yedisinde ise iğsi ve dev hücrelerin karışımı var idi. Takip süresi sonunda 28 ölüm kaydedildi. Ortalama sağkalım 62 ay idi. So nuç: Cerrahi ve adjuvan kemoradyoterapiye rağmen, pleomorfik karsinom sık uzak metastaza bağlı olarak kötü prognoz ile ilişkilendirilmektedir. Evreleme özellikle N 0 hastalarda önemli bir prognostik faktör olarak gözükmektedir.

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“…Metastatic lesions are noted in the adrenal gland, kidney, brain, bone, and gastrointestinal tract. 2,7,8 Metastasis of pulmonary carcinosarcoma to the small bowel has been reported only once previously. 9 Laparoscopic small bowel resection is performed for a variety of benign diseases.…”

Section: Introductionmentioning

confidence: 98%

Laparoscopic Small Bowel Resection of Metastatic Pulmonary Carcinosarcoma

Felsher

Brodsky²,

Brody³

2003

Journal of Laparoendoscopic & Advanced Surgical Techniques

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Carcinosarcoma of the lung is a rare malignancy consisting of both epithelial and mesenchymal components. Although metastatic disease is common, metastatic disease to the small intestine is rare and has been reported only once in the literature. An unusual case of pulmonary carcinosarcoma with metastasis to the small bowel is presented. At the time of laparoscopic exploration, a 4 x 4 cm mass was seen in the jejunum involving the adjacent mesentery. The affected small bowel and mesentery were resected laparoscopically and bowel continuity was restored through an entirely intracorporeal technique. Laparoscopic small bowel resection can be performed safely in the setting of malignant disease and imparts many of the benefits of minimally invasive surgery.

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Carcinosarcoma of lung associated with asbestosis

Cited by 19 publications

References 3 publications

Sarcomatoid Carcinoma of the Stomach with Heterologous Elements

Sarcomatoid Carcinoma of the Stomach with Heterologous Elements

Clinical characteristics and prognosis of pulmonary pleomorphic carcinoma: retrospective analysis of 57 patients

Laparoscopic Small Bowel Resection of Metastatic Pulmonary Carcinosarcoma

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