Carcinosarcoma of ovary with its various immunohistochemical expression: Report of a rare case

Dasgupta, Senjuti; Bose, Debdas; Bhattacharyya, Nirmal Kumar; Biswas, Pranab Kumar

doi:10.4103/0973-1482.147390

Cited by 9 publications

(13 citation statements)

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“…According to the combination theory, both the malignant epithelial component and the sarcoma component came from pluripotent stem cells that have divergent differentiation. Finally, the conversion theory suggested that the sarcoma component of the tumor resulted from the evolution of the carcinomatous component of the tumor ( 14 , 15 ).…”

Section: Discussionmentioning

confidence: 99%

Management of a rare ovarian carcinosarcoma: A case report and literature review

Fu¹

2022

Exp Ther Med

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Ovarian carcinosarcoma (OCS) is a rare and lethal gynecological cancer. The present study reports on the case of a 61-year-old post-menopausal female with abdominal distension who was detected to have a large OCS. The patient underwent cytoreductive surgery, including sub-extensive hysterectomy, bilateral adnexectomy, sigmoid colon and partial rectal resection, and lymph node dissection. Postoperative pathology of the bilateral adnexal masses revealed carcinosarcoma. The main components of the carcinoma included serous carcinoma and a small amount of squamous cell carcinoma. The sarcoma components mainly contained fibrosarcoma, as well as a small amount of chondrosarcoma and rhabdomyosarcoma. Infiltrating cells in cancer tissues or metastasis were observed in the serosal surface, muscular and subserosal layers of the uterus, as well as the sigmoid colon and part of the rectum. The patient was diagnosed postoperatively with International Federation of Gynecology and Obstetrics stage IIIC ovarian carcinosarcoma and T3cN1M0 based on the TNM system. The patient then received six cycles of combination chemotherapy using carboplatin, paclitaxel plus bevacizumab. As severe myelosuppression occurred during and after chemotherapy, and bevacizumab was expensive, bevacizumab therapy was not maintained after chemotherapy. However, following chemotherapy, the patient received niraparib oral maintenance therapy. At 6 months after the sixth chemotherapy, cancer antigen 125 levels dropped to 4.55 U/ml (within normal range). Short-term follow-up of 6 months after the end of chemotherapy indicated that the patient had a remission prognosis based on the ultrasonography, computed tomography, magnetic resonance imaging examinations and serum tumor marker levels. The present study indicated that combined chemotherapy and targeted therapy after cytoreductive surgery may be a promising way for the treatment of OCS.

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Section: Discussionmentioning

confidence: 99%

Management of a rare ovarian carcinosarcoma: A case report and literature review

Fu¹

2022

Exp Ther Med

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“…IHC can be used to identify the biphasic population but the studies on overexpression of p53 and Ki67 index as prognostic indicators has not yet shown statistically significant results. 7,8…”

Section: Discussionmentioning

confidence: 99%

The worst of both worlds - carcinosarcoma of the ovary: A case report

Kareddy²,

M³

et al. 2022

ACHR

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“…Some studies believe that OCS occur most commonly in postmenopausal women of low parity and often present with disseminated disease at diagnosis with the average age was 65.5 years (range 55–77 years) [ 1 , 8 ]. However, one patient in 40 years of age were represented by Dasgupta [ 7 ]. Menon et al [ 9 ] showed the age at time of diagnosis of OCS varied from 33 to 70 years with a median age of 51 years.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, CT and / or MRI can provide more comprehensive information in the diagnosis and therapy. To date, numerous studies have focused on histopathological characteristics, clinical manifestations and prognosis of OCS [ 1 , 2 ], by contrast, there have been only scattered case studies that have described the imaging findings [ 3 – 7 ]. The purpose of the present study was to analyze the clinical features, CT and MRI characteristics of OCS, and to describe the pathological features and prognosis.…”

Section: Introductionmentioning

confidence: 99%

Primitive ovarian carcinosarcoma: a clinical and radiological analysis of five cases

Zhang

Zou

2020

J Ovarian Res

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Background Ovarian carcinosarcomas (OCS) are very rare tumors composed of a mixture of carcinomatous and sarcomatous elements. There have been only scattered case studies that have described the imaging findings. In order to improve the awareness of this rare tumor, this study aimed to analyze the clinical and imaging features of five cases of OCS confirmed by surgical pathologic evaluation. Methods This retrospective study includes five OCS patients diagnosed and treated at our institute. The clinical course and imaging findings of all patients were retrospectively analyzed. The patients were 31 to 59 years of age. All five patients underwent CT scans, two underwent MRI scans. Results The five patients have no specific symptoms. Four patients had elevated CA 125 levels and three patients had elevated CA 153 levels. All patients had unilateral tumors, four in the left ovary, one in the right ovary. The largest transverse diameter of the tumors ranged from 11 cm to 14 cm. Two tumors showed solid masses with unequally sized cystic areas or necrosis, one showed a multilocular cystic mass with a large solid protrusion, two tumors showed a larger cystic mass with multiple mural nodules. The solid components of the tumors demonstrated restricted diffusion (the average ADC value being 998 mm2/s and 1102 mm2/s, respectively), and showed moderate or obvious enhancement. All five patients were treated by surgical resection and adjuvant chemotherapy. One patient is currently undergoing post-operative chemotherapy 1 month after operation and clinical stable. Three patients survived and showed no obvious recurrence and / or metastasis in follow-up from 9 to 59 months. One patient died from recurrence and metastasis. Conclusions OCS are rare and demonstrate variable CT and MRI morphological appearances. Due to the heterogeneous nature and very low morbidity of OCS, combination of careful analysis of imaging findings and clinical features might be useful for a more accurate diagnosis of OCS.

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Carcinosarcoma of ovary with its various immunohistochemical expression: Report of a rare case

Cited by 9 publications

References 0 publications

Management of a rare ovarian carcinosarcoma: A case report and literature review

Management of a rare ovarian carcinosarcoma: A case report and literature review

The worst of both worlds - carcinosarcoma of the ovary: A case report

Primitive ovarian carcinosarcoma: a clinical and radiological analysis of five cases

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