Carcinosarcoma of pancreas with liver metastasis combined with gastrointestinal stromal tumour of the stomach: is there a good prognosis with the complete resection?

Shen, Zhanlong; Wang, S.; Ye, Y.J.; Wang, Y.L.; Sun, Kunkun; Yang, Xiaodong; Jiang, Kewei

doi:10.1111/j.1365-2354.2008.00977.x

Cited by 29 publications

(18 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The patients survived an average of only 6 months after surgery. Shen et al [7] reported an old woman with carcinosarcoma of pancreas with liver metastasis combined with gastrointestinal stromal tumor of the stomach. Though the patient received radical resection, she died 2 months postoperatively because of recurrence.…”

Section: Discussionmentioning

confidence: 98%

Long-term recurrence-free survival in a patient with pancreatic carcinosarcoma: A case report with a literature review

Zhu¹,

Liu²,

Zhu³

2011

Med Oncol

View full text Add to dashboard Cite

Here, we presented a case of carcinosarcoma of the pancreas in a 53-year-old woman. The carcinosarcoma was in the head of pancreas. She underwent a pancreaticoduodenectomy. The tumor was grossly yellowish-whitish. Histologic evaluation of the tumor revealed 2 elements separated from each other. One component was conventional pancreatic ductal adenocarcinoma, and the other component showed sarcomatous growth pattern composed of pleomorphic spindle cells. Immunohistochemically, the adenocarcinoma component was reactive for antibodies to cytokeratin 18 and epithelial membrane antigen. The sarcomatous component was reactive for smooth muscle antibody. These findings led to a diagnosis of pancreatic carcinosarcoma. The patient was treated with gemcitabine, adriamycin, and cisplatin after the operation. Although previously reported patients with pancreatic carcinosarcoma showed a very poor outcome, this patient has remained free of recurrence for 20 months, which is the longest recurrence-free survival time recorded for this type of cancer. This treatment plan may be a feasible option.

show abstract

Section: Discussionmentioning

confidence: 98%

Long-term recurrence-free survival in a patient with pancreatic carcinosarcoma: A case report with a literature review

Zhu¹,

Liu²,

Zhu³

2011

Med Oncol

View full text Add to dashboard Cite

show abstract

“…Shen et al (9) reported a carcinosarcoma of the pancreas with liver metastasis combined with a gastrointestinal stromal tumor of the stomach in a 72-year-old female. A radical resection, including a pancreaticoduodenectomy, left hepatic lobe resection and local resection, of the gastric mass was performed, however, the patient succumbed to multiple organ failure at 2 months post-surgery.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic left pancreatectomy for pancreatic sarcomatoid carcinoma: A case report and review of the literature

et al. 2013

View full text Add to dashboard Cite

Sarcomatoid carcinoma of the pancreas is extremely rare. The current report presents a case of carcinosarcoma of the pancreas in a 48-year-old male. Pre-operative computed tomography scans revealed a large complex cystic and solid mass in the tail of the pancreas; the patient underwent a laparoscopic spleen-preserving left pancreatectomy. The tumor was shown to be made of cystic and solid components, with a grossly grey/ white appearance. A histological evaluation of the tumor revealed two elements separated from each other, one component was a pancreatic ductal adenocarcinoma and the other component exhibited a sarcomatous growth pattern, composed of spindle cells and multinucleated giant cells. Immunohistochemically, the epithelial area was positive for cytokeratin (CK) and negative for vimentin, while the sarcomatoid area was negative for CK and positive for vimentin. These observations confirmed a diagnosis of pancreatic carcinosarcoma. Although the patient was treated by gemcitabine following surgery, the outcome was extremely poor and the patient succumbed to sarcomatoid carcinoma three months after the treatment.

show abstract

“…One report mentioned sarcoma. Data were not large enough for statistical analysis (2,4,(7)(8)(9)(10)(11)(12)(13)(14).…”

Section: Resultsmentioning

confidence: 99%

Primary Pancreas Sarcoma, Optimal Treatment and Prognostic Factors

Omidvari

Nasrolahi

Kadkhodaei

et al. 2015

Rep Radiother Oncol

View full text Add to dashboard Cite

Context: Sarcoma is a rare human cancer and pancreatic sarcoma is even rarer. Its treatment and clinical history and prognosis are not well described.Evidence Acquisition: In this review, we collected all articles in the English language found in PubMed that were published between January 2000 to August 2015 to draw conclusions. We found 170 articles in total and 124 articles were excluded. The remaining 46 reports and information of 55 patients were collected and analyzed.Results: Mean age was 57.1 ± 16.7 years and male/female ratio was 27/28. The most common presenting symptom was pain. In 31 cases no adjuvant treatment was prescribed. Others received different chemotherapy agents and only two cases received radiotherapy. Mean tumor size was 9.0 ± 6.8 cm (1 -27 cm) and the most common type was leiomyosarcoma (16 patients). Nine patients had carcinosarcoma and six cases had MFH. The most common site of metastasis was liver, 14 patients had liver metastasis at presentation. Median survival was 14 months. One, three and five year overall survival were 78.4, 48.5 and 48.5 percent, respectively. We found no effective clinical factor in survival.Conclusions: Pancreatic sarcoma is a rare disease and an optimal treatment, such as surgery, chemotherapy or radiotherapy is not well defined.Keywords: Pancreas, Sarcoma, Treatment ContextMost pancreatic tumors are epithelial cancers. Adenocarcinoma is the most common malignancy in this organ. Stromal pancreatic tumors are usually GIST or neurogenic cancers. Primary sarcoma of pancreas (PS) are very rare and most be differentiated from gastrointestinal and retroperitoneal sarcoma with extension to pancreas (1). Among 15,000 patients who were referred to our center for treatment over a 10-year period (2003 -2013), 95 cases had sarcoma. Among those who had sarcoma, only one case had pancreas sarcoma. Most pancreatic sarcomas (PS) are diagnosed in autopsy (1). Presenting symptoms are nonspecific and are abdominal pain, mass, epigastric tenderness or even may present as acute pancreatitis (1, 2). In order to elucidate the clinical course and behavior and responses to treatment, we searched PubMed for information regarding primary pancreatic sarcoma. Evidence AcquisitionWe searched PubMed for primary pancreatic sarcomas. Only studies that reported clinical data were included in the study. Review articles (without reporting a new case), animal studies and genetic or radiologic studies were excluded. Keywords in the title were: "sarcoma" or "leiomyosarcoma" or "liposarcoma" or "rhabdomyosarcoma" or "mesenchymal" or "malignant fibrous histiocytomas" AND "pancreas" or "pancreatic". Articles that had no information about a new patient or were published before the year 2000 were excluded. Metastasis to pancreas (non-primary pancreatic tumors) and non-English reports were also exclusion criteria.All clinical data, including age, sex, and disease presentation, type of sarcoma, and completeness of resection, treatment, site of metastasis and survival were collected. Some studies r...

show abstract

Carcinosarcoma of pancreas with liver metastasis combined with gastrointestinal stromal tumour of the stomach: is there a good prognosis with the complete resection?

Cited by 29 publications

References 18 publications

Long-term recurrence-free survival in a patient with pancreatic carcinosarcoma: A case report with a literature review

Long-term recurrence-free survival in a patient with pancreatic carcinosarcoma: A case report with a literature review

Laparoscopic left pancreatectomy for pancreatic sarcomatoid carcinoma: A case report and review of the literature

Primary Pancreas Sarcoma, Optimal Treatment and Prognostic Factors

Contact Info

Product

Resources

About