Carcinosarcoma of the gallbladder: Report of a case

Lopez, Gloria E.; Strimel, William H.; Herrera-Ornelas, Lemuel

doi:10.1002/jso.2930290405

Cited by 16 publications

(8 citation statements)

References 4 publications

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“…A search of the English language literature since 1967 revealed only 14 cases of carcinosarcoma of the gallbladder, including our patient 1,2,,,19. The mean age of the patients was 71.4 years (range, 45–90), and the female‐to‐male ratio was 2.3 to 1.…”

Section: Discussionmentioning

confidence: 94%

“…Carcinosarcoma of the gallbladder, first described by Landsteiner in 1907,9 is a rare but clinicopathologically characteristic tumor exhibiting both carcinomatous and sarcomatous lesions. This tumor has been given complicated designations, including carcinosarcoma,, malignant mixed tumor, and malignant mixed mesodermal tumor 7. The multiplicity of terminology reflects the uncertain histogenesis of the sarcomatous component.…”

Section: Discussionmentioning

confidence: 99%

“…Carcinosarcoma of the gallbladder is a very rare malignant tumor that consists of both carcinomatous and sarcomatous elements . Various nomenclatures, including malignant mixed tumor and malignant mixed mesodermal tumor,7 have been used in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Carcinosarcoma of the gallbladder: A case report and review of the literature

Uesaka

Nimura

Hayakawa

et al. 1995

J Hep Bil Pancr Surg

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Abstract:A rare case of a huge carcinosarcoma of the gallbladder is presented. Despite a tumor thrombus in the portal vein, this tumor was resected successfully by extended right hepatic lobectomy with right caudate lobectomy and gastroduodenectomy. However, hepatic metastases developed rapidly, and the patient died only 3 months after surgery. Macroscopically, a whitish tumor filled the body and neck of the gallbladder and involved the right lobe and left medial segment of the liver, stomach, and duodenum. Microscopically, the neoplasm consisted of both carcinomatous and sarcomatous components. The former contained adenocarcinoma and squamous cell carcinoma, which were observed in the wall of the gallbladder. The latter comprised the bulk of the mass and contained malignant cartilage and osteoid. ImmunohistochemicaIly, the sarcomatous cells reacted to antibodies for epithelial membrane antigen and cytokeratin, but were negative for vimentin antibody. Although stromal differentiation into osteoid and cartilage was noted, the sarcomatous component was felt to be derived from mesenchymal metaplasia of the carcinomatous cells. Only 14 cases of carcinosarcoma of the gallbladder have been reported in the English language literature since 1967.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Carcinosarcoma of the gallbladder: A case report and review of the literature

Uesaka

Nimura

Hayakawa

et al. 1995

J Hep Bil Pancr Surg

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“…Sarcomatoid carcinoma has been reported in many organs including the uterus, lung, esophagus, kidney and pancreas, 1–5 although it is very rare in the gallbladder. To our knowledge only 39 cases of sarcomatoid carcinoma of the gallbladder have been reported in the English literature 6–28 . In most cases the epithelial component of the sarcomatoid carcinoma of the gallbladder consists of adenocarcinoma and there have only been two reported cases in which it consisted of small cell carcinoma and/or undifferentiated carcinoma.…”

mentioning

confidence: 99%

Sarcomatoid carcinoma with components of small cell carcinoma and undifferentiated carcinoma of the gallbladder

Takahashi

Fukushima

Fukusato

et al. 2004

Pathology International

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We report a case of sarcomatoid carcinoma with components of small cell carcinoma and undifferentiated carcinoma of the gallbladder. An 84-year-old woman was admitted to our university hospital with right upper abdominal pain and back pain. Clinical diagnosis of a gallbladder tumor was made based on the findings of abdominal ultrasonography, computed tomography and endoscopic retrograde cholangiopancreatography, and a cholecystectomy was carried out. On gross examination a pedunculated polypoid tumor protruded into the lumen of the gallbladder. Histologically the tumor was composed of carcinomatous and sarcomatous components; the carcinomatous component consisted mainly of small cell carcinoma and undifferentiated carcinoma. In general, the carcinomatous component of sarcomatoid carcinoma of the gallbladder consists of adenocarcinoma, and there have only been two previously reported cases in which the carcinomatous component consisted of small cell carcinoma or undifferentiated carcinoma. Because the patient's prognosis may be influenced by the peculiar carcinomatous component in such cases, it is important to accumulate case reports that clarify their clinicopathological features.

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“…Carcinosarcomas are rare neoplasms, which are composed of malignant epithelial and mesenchymal elements that grow intermingled with each other, 1 and are usually found in the uterine body or in the pelvic structures of Müllerian origin. 2 Carcinosarcomas of the gallbladder are rare, and 28 cases have been described in the English literature [3][4][5][6][7] and 34 cases in the Japanese literature.…”

Section: Introductionmentioning

confidence: 99%

So-Called Carcinosarcoma of the Gallbladder; Spindle Cell Carcinoma of the Gallbladder: Report of a Case

et al. 2002

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We report a so-called carcinosarcoma of the gallbladder in a 53-year-old man. The findings of ultrasonography, computed tomography, endoscopic retrograde cholangiopancreatography, and angiography revealed a large mass of the gallbladder with a cholesterol stone. He underwent three operations, and died from liver failure with multiple liver metastasis immediately after the third operation. A pathological examination revealed neoplastic tissue composed of sarcomatous and glandular components. Hematoxylin-eosin stain proved the presence of carcinosarcoma in the gallbladder, but an immunohistochemical study proved that the sarcomatous component was stained by antivimentin and also anticytokeratin antibodies, which thus proved it to be so-called carcinosarcoma of the gallbladder. As a result, an immunohistochemical study is considered to provide valuable information regarding the identification of sarcomatous elements in such cases.

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Carcinosarcoma of the gallbladder: Report of a case

Abstract: Carcinosarcomas of the gallbladder are rare tumors characterized by malignant epithelial and mesenchymal components that grow intermingled into each other. Herein we present a case that illustrates the difficulties in the diagnosis and the clinical management of this entity.

Cited by 16 publications

References 4 publications

Carcinosarcoma of the gallbladder: A case report and review of the literature

Carcinosarcoma of the gallbladder: A case report and review of the literature

Sarcomatoid carcinoma with components of small cell carcinoma and undifferentiated carcinoma of the gallbladder

So-Called Carcinosarcoma of the Gallbladder; Spindle Cell Carcinoma of the Gallbladder: Report of a Case

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