Carcinosarcoma of the larynx consisting of squamous cell carcinoma and inflammatory myofibroblastic tumor components

Suzuki, Shinsuke; Hanata, Kyoshi; Toyoma, Satoshi; Nanjo, Hiroshi; Saito, Hidekazu; Iikawa, Nobuko; Ishikawa, Kazuo

doi:10.1016/j.anl.2015.10.014

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…1 In this regard, Kichenaradjou et al recommend longer follow-up periods due to the unpredictable behavior of these tumors. 12 However, the follow-up period we employed is in line with that published by the majority of the authors: Tay and Balakrishnan (12 months), 2 Yan and Hu (12 months), 6 Suzuki et al (14 months), 7 Do et al (6 months), 9 Kieu et al (12 months), 10 Girardi et al (14 months). 13…”

Section: Discussionsupporting

confidence: 64%

“…Other synonyms include postinflammatory tumor, plasma cell granuloma, and IMT. 2,6,7 The fundamental question about the pathogenesis of IMT is whether it is reactive or a true neoplasm. Because rearrangements and expression of the ALK gene have been found in 30% to 60% of IMT, it is now classified as a mesenchymal neoplasm rather than a reactive process.…”

Section: Discussionmentioning

confidence: 99%

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Laryngeal Myofibroblastic Tumor: A New Therapeutic Approach. A Case Report

et al. 2020

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Myofibroblastic tumors are rare lesions which can affect any part of the body. Although benign, their mass effect causes symptoms that can become life-threatening. Supraglottic laryngeal involvement is extremely rare, with only 4 cases described in the English literature. Because the pathophysiology is unknown and the incidence is so low, there is no standardized therapeutic management, although for laryngeal tumors surgery has traditionally been the preferred initial option. Another less common option is intravenous and oral corticosteroid therapy, but this is usually reserved for myofibroblastic tumors in other head and neck sites that are more difficult to access surgically, or patients who cannot undergo surgery. These lesions have a very high tendency to recur, and morbidity rates are therefore also high. We present a case of supraglottic myofibroblastic tumor in which we elected high-dose corticosteroid therapy as the only form of treatment. With this new therapeutic approach, we avoided the undesirable effects of the usual type of surgery. At the 12-month follow-up, the patient is in complete remission.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Laryngeal Myofibroblastic Tumor: A New Therapeutic Approach. A Case Report

et al. 2020

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“…As far as we know, this case is the second reported case of this coexistence. The other case was reported by Suzuki et al 29 …”

Section: Discussionmentioning

confidence: 87%

Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings

Doğan

Vural

Kahriman

et al. 2020

Brazilian Journal of Otorhinolaryngology

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“…CS is a rare biphasic malignant tumor consisting of both carcinomatous and sarcomatous components that can affect various organs 1 5 . The most common carcinomatous components are adenocarcinoma, followed by squamous cell carcinoma 16 .…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma ex Pleomorphic Adenoma of the Submandibular Gland in a 64-Year-Old Man: A Case Report

et al. 2018

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Carcinosarcoma (CS) is a rare tumor, consisting of both carcinomatous and sarcomatous components. In this paper, we present a case of CS arising from a pleomorphic adenoma (PA) of the submandibular gland. A 64-year-old Japanese man presented with a left submandibular mass that had developed for 20 years with complaints of pain for the last 3 months. Magnetic resonance imaging showed a lesion involving the left submandibular gland. The patient underwent total dissection of the left submandibular gland and left cervical lymph nodes. Upon gross examination, the mass appeared completely covered by fibroadipose tissue measuring 46×42×45 mm; sectioning revealed a solid-white nodule with central bleeding and necrosis, invading into the surrounding adipose tissue. Microscopically, the presence of carcinomatous and sarcomatous components in the fibro-myxomatous stroma was detected, suggestive of pre-existing PA. The carcinoma component was diagnostic of salivary adenocarcinoma, not otherwise specified, whereas the sarcomatous component exhibited features of osteosarcoma characterized by formation of osteoid. As the border between the carcinomatous and sarcomatous components was not evident, CS may have occurred via transformation of the carcinoma into sarcoma. Tumor metastasis was detected in the cervical lymph nodes. Immunohistochemically, AE1/AE3 expression was noted in the carcinomatous component, but not in the osteosarcoma component. Both components were diffusely positive for vimentin. Four months after the operation, the patient developed a metastatic CS lesion in the lung, suggesting tumor aggression.

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Carcinosarcoma of the larynx consisting of squamous cell carcinoma and inflammatory myofibroblastic tumor components

Cited by 5 publications

References 13 publications

Laryngeal Myofibroblastic Tumor: A New Therapeutic Approach. A Case Report

Laryngeal Myofibroblastic Tumor: A New Therapeutic Approach. A Case Report

Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings

Carcinosarcoma ex Pleomorphic Adenoma of the Submandibular Gland in a 64-Year-Old Man: A Case Report

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