2021
DOI: 10.7759/cureus.18546
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Carcinosarcoma of the Nasal Septum: A Case Report and Review of the Literature

Abstract: We report a case of a 62-year-old man with epistaxis and right-sided nasal obstruction. Nasal endoscopy revealed an exophytic mass arising from the anterior septum that extended posteriorly to the osteo-meatal complex. Excision with endoscopic sinus surgery was performed. Carcinosarcoma was diagnosed based on histopathology and immunohistochemical studies. The patient declined surgery and opted for chemoradiation therapy for the residual tumor. Six weeks after completion of the treatment, clinical resolution o… Show more

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Cited by 3 publications
(9 citation statements)
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“…Carcinosarcoma is a biphasic variant of sarcomatoid carcinoma that may arise from any squamous epithelium of the body such as respiratory tract, upper gastrointestinal tract, female reproductive organs. 1,2,4,8,9 In the head and neck region, the most common site is in the salivatory glands. 1,3 This is an extremely rare and aggressive neoplasm in the sinonasal tract.…”
Section: Discussionmentioning
confidence: 99%
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“…Carcinosarcoma is a biphasic variant of sarcomatoid carcinoma that may arise from any squamous epithelium of the body such as respiratory tract, upper gastrointestinal tract, female reproductive organs. 1,2,4,8,9 In the head and neck region, the most common site is in the salivatory glands. 1,3 This is an extremely rare and aggressive neoplasm in the sinonasal tract.…”
Section: Discussionmentioning
confidence: 99%
“…3 Sinonasal carcinosarcomas typically have a rapid growth, extensive local destruction and high recurrence rate. 4,5 Sinonasal carcinosarcomas are most commonly diagnosed in elderly individuals and are slightly more common in men than women. 6 The exact cause of sinonasal carcinosarcoma is not yet known, but it is believed to be associated with exposure to certain environmental toxins such as wood dust, leather dust and textile fibers.…”
Section: Introductionmentioning
confidence: 99%
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“…1 Clinical case reports suggests sinonasal carcinosarcomas should be treated with surgery and adjuvant radiotherapy, with an unclear role for chemotherapy. 4 There are limited outcomes data due to the rarity of sinonasal carcinosarcomas. To date the literature consists of case reports [1][2][3][4][5][6][7][8][9] and one case-control analysis by Patel et al 10 using the Surveillance, Epidemiology, and End Results (SEER) database to calculate a 5-year disease-specific survival of 48.5% based on 15 cases.…”
Section: Introductionmentioning
confidence: 99%