Cardiac and Metabolic Effects of Anabolic-Androgenic Steroid Abuse on Lipids, Blood Pressure, Left Ventricular Dimensions, and Rhythm

Achar, Suraj; Rostamian, Armand; Narayan, Sanjiv M.

doi:10.1016/j.amjcard.2010.05.013

Cited by 231 publications

(207 citation statements)

References 95 publications

(123 reference statements)

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“…2 Long-term consequences of AAS misuse include cardiovascular, endocrine, and psychiatric complications. 3,4 General population estimates suggest that AAS misuse is not uncommon among adolescent boys, with prevalence rates varying between 1.0% and 5.4%, 5,6 and nearly one-quarter of adult men who misuse AAS report initial use during adolescence. 7 One population that may be at an increased risk of misusing AAS is sexual minority (gay and bisexual) boys.…”

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confidence: 99%

Sexual Orientation and Anabolic-Androgenic Steroids in US Adolescent Boys

Blashill

Safren

2014

Pediatrics

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WHAT'S KNOWN ON THIS SUBJECT: Anabolic-androgenic steroid misuse is not uncommon among adolescent boys, and initial use in adolescence is associated with a host of maladaptive outcomes, including cardiovascular, endocrine, and psychiatric complications. WHAT THIS STUDY ADDS:This is the first known study to examine prevalence rates of anabolic-androgenic steroid misuse as a function of sexual orientation. A dramatic disparity was found, in that sexual minority boys reported misuse at a much higher rate than heterosexual boys. RESULTS: Sexual minority adolescent boys were at an increased odds of 5.8 (95% confidence interval 4.1-8.2) to report a lifetime prevalence of AAS (21% vs 4%) compared with their heterosexual counterparts, P , .001. Exploratory analyses suggested that increased depressive symptoms/suicidality, victimization, and substance use contributed to this disparity.CONCLUSIONS: This is the first known study to test and find substantial health disparities in the prevalence of AAS misuse as a function of sexual orientation. Prevention and intervention efforts are needed for sexual minority adolescent boys. Pediatrics 2014;133:469-475

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confidence: 99%

Sexual Orientation and Anabolic-Androgenic Steroids in US Adolescent Boys

Blashill

Safren

2014

Pediatrics

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“…Echocardiographic studies have derived conflicting results regarding the effects of AAS on left ventricular mass and function in athletes [9,10]. The results of the studies indicate a prevalence of both physiological and pathological cardiac hypertrophy in athletes taking anabolic steroids To the best of our knowledge, no study has investigated the effect of AAS use on cardiac IGF-1 content in response to exercise training.…”

Section: Introductionmentioning

confidence: 78%

“…The rats of UTr and Tr groups were given the same volume of sesame oil according to the same schedule. The TP dose (20 mg/250 g BW) was administered compared to non AAS-users [9,10]. It has been suggested that cardiac hypertrophy, after ingestion of high-doses of steroids, might be the result of the interactions between circulating anabolic hormones concentrations and growth factor expression in the heart in response to training overload [11].…”

Section: Experimental Animals and Hormonal Treatmentmentioning

confidence: 99%

Cardiac hypertrophy and IGF-1 response to testosterone propionate treatment in trained male rats

Żebrowska¹,

Sadowska-Krępa²,

Jagsz³

et al. 2017

Open Life Sciences

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Abstract:Objective: Several studies have suggested that testosterone exerts a growth-promoting effect in the heart. Limited data are available regarding interactions between possible endocrine/paracrine effects in response to exercise training. Therefore, we examined supraphysiological testosterone-induced heart hypertrophy and cardiac insulin-like growth factor (IGF)-1 content in sedentary and exercise-trained rats. Design: Male Wistar rats (n=33) were randomly allocated to groups with a 6-week endurance training with or without testosterone, and sedentary animals with or without testosterone. The hormone (20 mg/250 g body weight was administrated once a week for six weeks. After six weeks the animals were anesthetized, euthanized and the heart was excised and weighed. The left ventricle was separated for biochemical analyses. Results: Testosterone-treated animals showed significantly higher cardiac IGF-1 content compared to untreated control and trained groups (p=0.01). The administration of supraphysiological testosterone significantly increased the heart weight to body weight ratio (HW/BW, p<0.01). A significant positive correlation was seen between IGF-1 levels and the HW/BW ratio (p=0.002; r=0.50) and between serum total testosterone levels and HW/BW (p=0.000; r=0.79). Conclusions:The results demonstrate that increased

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“…1, 3 Os efeitos adversos podem atingir e provocar danos em múltiplos órgãos e sistemas, da qual são exemplos as tendinopatias e as roturas tendinosas.…”

Section: Introductionunclassified

Avulsão Distal do Tendão Bicipital Associado ao Uso Prolongado de Esteroides Androgénicos Anabolizantes

Couto¹,

Lopes²,

Ramos³

et al. 2018

Revdesp

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RESUMO / ABSTRACTO uso de esteroides anabolizantes para melhorar o desempenho atlético constitui uma realidade na atividade desportiva. É necessário saber reconhecer indicadores de abuso, projetar a sua prevenção e tratar devidamente as eventuais complicações. Os autores descrevem um caso de avulsão distal do tendão bicipital num atleta de Culturismo, consumidor de esteroides injetáveis para ganho de maior massa muscular. Referiu dor aguda e súbita, com retração bicipital, equimose medial e fraqueza durante a supinação e flexão do antebraço. Os doentes que desejam manter a função total do membro têm na reparação cirúrgica precoce a melhor opção, pelo que os autores optaram pelo seu tratamento com técnica de incisão anterior isolada e fixação tendinosa com duas âncoras de sutura à tuberosidade radial. Seguiu-se um período de imobilização braquiopalmar durante três semanas e programa de reabilitação durante oito semanas, com recuperação total da função. The use of anabolic steroids to improve athletic performance is a reality in sports activity. It is necessary to be able to recognize abuse signs, design the prevention and deal properly with possible complications. The authors describe a case of distal bicipital tendon avulsion in a Bodybuilding PALAVRAS-CHAVE / KEYWORDSTendão, bicípite, avulsão, esteroides Tendon, biceps, avulsion, steroids Caso clínicoRev. Medicina Desportiva informa, 2018; 9(4):7-10. https://doi.org/10.23911/rotura_tendao_esteroides IntroduçãoOs esteroides androgénicos anabolizantes (EAA) são análogos sinté-ticos da testosterona e derivados, manipulados laboratorialmente para maximizar os efeitos anabóli-cos e minimizar os efeitos laterais androgénicos.1,2 Frequentemente, o abuso de suplementos ergogénicos -substâncias usadas para melhorar o desempenho atlético, energia, aparência física ou a capacidade de trabalho -têm sido usados não apenas por atletas profissionais, mas também por amadores.1,3 Os efeitos adversos podem atingir e provocar danos em múltiplos órgãos e sistemas, da qual são exemplos as tendinopatias e as roturas tendinosas. 1,2,5Acredita-se que este efeito se deva, não só à alteração irreversível da estrutura do colagénio, diminuindo a sua elasticidade, mas também à força desproporcionada dos múscu-los hipertrofiados, não permitindo uma adaptação equivalente dos tendões. 1Uma das lesões mais importante nos consumidores de EAA é precisamente a avulsão distal do tendão bicipital (podendo ser parcial ou completa). No passado foi descrita como sendo uma patologia rara, mas diversos casos têm sido publicados com uma frequência crescente 8 : representa aproximadamente 10% das roturas do músculo bicipital, das quais 86% são na extremidade dominante e 93% em doentes masculinos (entre os 40 e 60 anos).6-8 Estima-se que afeta 1.2/100000 pessoas anualmente 7 , sendo que apenas 29% destes doentes possuem uma atividade desportiva intensa e exigente. 6A lesão ocorre quando uma força de extensão não expectada é aplicada a um braço em flexão.7,8 A avulsão (ou rotura) ocorre tipicamente ao níve...

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Cardiac and Metabolic Effects of Anabolic-Androgenic Steroid Abuse on Lipids, Blood Pressure, Left Ventricular Dimensions, and Rhythm

Cited by 231 publications

References 95 publications

Sexual Orientation and Anabolic-Androgenic Steroids in US Adolescent Boys

Sexual Orientation and Anabolic-Androgenic Steroids in US Adolescent Boys

Cardiac hypertrophy and IGF-1 response to testosterone propionate treatment in trained male rats

Avulsão Distal do Tendão Bicipital Associado ao Uso Prolongado de Esteroides Androgénicos Anabolizantes

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