Cardiac arrhythmias secondary to hormone therapy in trans women

Wamboldt, Rachel; Haseeb, Sohaib; Waddington, Ashley; Baranchuk, Adrián

doi:10.1080/14779072.2019.1606713

Cited by 13 publications

(9 citation statements)

References 37 publications

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“…The finding that atrial fibrillation as the commonest arrythmia in our cohort, compares well with prior analyses using the NIS for various disease states 5,8,9,13 . It has been hypothesized that low testosterone in transgender females may increase the risk for atrial and ventricular arrhythmia 14 . There is higher incidence of atrial fibrillation in postmenopausal women on estrogen replacement therapy.…”

Section: Discussionsupporting

confidence: 81%

Burden of arrythmias in transgender patients hospitalized for gender‐affirming surgeries

Antwi‐Amoabeng

Doshi

Adalja

et al. 2020

Journal of Arrhythmia

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Background We sought to describe the burden of arrhythmias and their impact on in‐hospital outcomes in transgender patients who underwent gender re‐assignment surgery. Methods The study utilized data from the National Inpatient Sample from January 2012 to September 2015. Results 16 555 adult transgender patients were included in this study. A total of 610 adults developed arrhythmia out of which atrial fibrillation (N = 475, 2.87%) was the most frequent arrhythmia. In‐hospital mortality increased substantially with arrhythmias. Conclusions New‐onset arrythmias, while infrequent in the inpatient setting is associated with significantly higher in‐hospital mortality and resource utilization.

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Section: Discussionsupporting

confidence: 81%

Burden of arrythmias in transgender patients hospitalized for gender‐affirming surgeries

Antwi‐Amoabeng

Doshi

Adalja

et al. 2020

Journal of Arrhythmia

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“…Estradiol metabolites may exert a protective effect on cardiac vessels by inhibiting vascular smooth muscle cells and cardiac fibroblasts and improving the function of vascular endothelial cells ( 28 ). In addition, some evidence has shown that estradiol has a significant effect on atrial electrophysiology, which may be related to the prevention of AF ( 29 ). This may also be one reason why women have a lower incidence of AF than men.…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiota and Metabolites in Atrial Fibrillation Patients and Their Changes after Catheter Ablation

et al. 2022

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“…This means that preserving the allograft with E2 (1 mg/mL) improves posttransplant kidney function. But the supplementation of E2 is usually relevant with multiside effects 20,21 . In order to find out whether this method of drug usage affects the internal environment of the recipient, plasma estradiol and testosterone were also examined after 24 hours of IRI.…”

Section: Discussionmentioning

confidence: 99%

“…But the supplementation of E2 is usually relevant with multiside effects. 20,21 In order to find out whether this method of drug usage affects the internal environment of the recipient, plasma estradiol and testosterone were also examined after 24 hours of IRI. The results showed that there were no differences among 5 groups.…”

mentioning

confidence: 99%

Protective effect of estradiol copreservation against kidney ischemia‐reperfusion injury

Zhou

Leung

et al. 2021

Artificial Organs

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Ischemia-reperfusion injury (IRI) is the major cause of delayed graft function (DGF) during the posttransplantation period. Estradiol (E2) prevents IRI-induced kidney dysfunction and tissue injury. However, many side effects limit E2's in vivo application. Recent evidence uncovers E2's expanded use in the field of transplantation.We aimed to study if and how E2 exerts protective activity during the period of kidney organ preservation. The autologous kidney transplant model in rats was first established. Rats were divided into 5 groups: normal group (N), sham group (sham), static cold storage (SCS) 4 hours group (control), SCS 4 hours + ethanol (1 µL/ mL) group (solvent), and SCS 4 hours + ethanol (1 µL/mL) + E2 (1000 ng/mL) group (E2). ERα expression under hypothermia was measured by western blotting.Moreover, biochemical analyses of plasma levels of creatinine, BUN, estradiol, and testosterone were examined. Among all groups, kidney tissues were collected and processed for further western blot analysis about ERα, eNOS, Bcl-2, and Bax expression, histological analyses such as H&E staining to evaluate pathological severity.In addition, a TUNEL assay is performed to evaluate apoptosis. E2 copreservation upregulated ERα expression under hypothermia. Moreover, E2 copreservation reduced levels of creatinine and BUN in plasma but without affecting estradiol and testosterone. Further, E2 copreservation increased expression of eNOS and antiapoptotic Bcl-2 and decreases expression of proapoptotic Bax. E2 copreservation significantly inhibited IRI-induced apoptosis and evidently improved pathological severity in the kidney of rats. E2 copreservation exerts protective activity against IRI-induced pro-inflammatory and proapoptotic effects in kidneys during organ preservation time and improves transplanted kidney function.

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Cardiac arrhythmias secondary to hormone therapy in trans women

Cited by 13 publications

References 37 publications

Burden of arrythmias in transgender patients hospitalized for gender‐affirming surgeries

Burden of arrythmias in transgender patients hospitalized for gender‐affirming surgeries

Gut Microbiota and Metabolites in Atrial Fibrillation Patients and Their Changes after Catheter Ablation

Protective effect of estradiol copreservation against kidney ischemia‐reperfusion injury

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