Cardiac autonomic innervation

Jamali, Hina K.; Waqar, Fahad; Gerson, Myron C.

doi:10.1007/s12350-016-0725-7

Cited by 36 publications

(27 citation statements)

References 115 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…is impairment occurs through an imbalance in the autonomic nervous system (ANS), especially in increased sympathetic modulation and decreased vagal tone leading to decreased heart rate variability (HRV) [5,7,10]. e measurement of these patterns can provide a sensitive and early indicator of serious health impairment in obese individuals with a higher risk of multimorbidity and early mortality [9], as they can be indicators of risk of death and cardiovascular disease [2,11,12], such as coronary artery disease, myocardial infarction, sudden death, heart failure and arrhythmias [7,13].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors Associated with Cardiac Autonomic Modulation in Obese Individuals

et al. 2020

View full text Add to dashboard Cite

Obesity leads to an imbalance in the autonomic nervous system, especially in increased sympathetic modulation and decreased vagal tone, and some anthropometric, metabolic, and lifestyle variables may increase the risk of developing cardiovascular disease. Objective. To analyze the association between cardiovascular autonomic modulation and biochemical and anthropometric markers, food intake, and physical activity level in severely obese individuals. Methodology. The present study is a cutout of a randomized clinical trial “Effect of nutritional intervention and olive oil in severe obesity” (DieTBra Trial), where the baseline data were analyzed. Anthropometric data, biochemical exams, heart rate variability (HRV), accelerometry, and 24 h recall (R24H) of obese patients (body mass index BMI ≥35 kg/m2) were collected. Results. 64 obese patients were analyzed, with a mean age of 39.10 ± 7.74 years (27 to 58 years). By HRV analysis, in the frequency domain, the obese had a higher predominance of sympathetic autonomic modulation (low frequency (LF) 56.44 ± 20.31 nu) and lower parasympathetic modulation (high frequency (HF) 42.52 ± 19.18 nu). A negative association was observed between the variables Homeostasis Evaluation Model (HOMA-IR) and HF (p=0.049). In the physical activity analysis, there was a negative association between moderate to vigorous physical activity and the sympathetic component (p=0.043), and for sedentary time (ST), there was a negative association with HF (p=0.049) and LF/HF (p=0.036) and a positive association with LF (p=0.014). For multiple linear regression, waist circumference (WC) and HOMA-IR values were negatively associated with HF (β = −0.685, p=0.010; β = −14.989, p=0.010; respectively). HOMA-IR (β = 0.141, p=0.003) and the percentage of lipids ingested (β = −0.030, p=0.043) were negatively associated with LF/HF. Conclusion. Among the cardiovascular risk variables studied, insulin resistance and central adiposity showed the greatest influence on cardiac autonomic modulation of obese, increasing the risk for cardiovascular disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Risk Factors Associated with Cardiac Autonomic Modulation in Obese Individuals

et al. 2020

View full text Add to dashboard Cite

show abstract

“…5,13 Cardiac autonomic nervous dysfunction may participate in various cardiac pathological processes. 15,16 Generally, the decrease in sympathetic activity or increase of vagus activity will offer a beneficial effect on cardiovascular function. 32 Our previous studies demonstrated that CIHH protects the heart against ischaemia/reperfusion or hypoxia/reoxygenation injury, and CIHH inhibits cardiac β-adrenergic receptor activity in papillary muscle, which suggests that the cardioprotection of CIHH may be correlated with a decrease in sympathetic nerve activity.…”

Section: Discussionmentioning

confidence: 99%

“…Cardiac autonomic nerve regulation plays an important role not only in maintaining normal cardiovascular function, but also in response to hypoxia, 13,14 and may also participate in various cardiac pathological processes, such as heart failure. 15,16 Our previous studies showed that CIHH inhibits cardiac β-adrenergic receptor activity in papillary muscle, hinting that the cardioprotection of CIHH may be correlated with cardiac autonomic regulation. 5 However, it is not clear whether CIHH affects the regulation of cardiac autonomic nervous system, including the sympathetic nervous system and vagus nerve.…”

mentioning

confidence: 99%

Effect of chronic intermittent hypobaric hypoxia on heart rate variability in conscious rats

Shi

Cheng

Ying-cai

et al. 2019

Clin Exp Pharma Physio

View full text Add to dashboard Cite

It was recognized for many years that the incidence of myocardial infarction was obviously low in highland habitant, suggesting that long-term adaptation to altitude hypoxia has cardiac protection. 1 Cumulating evidence demonstrates that exposure to chronic intermittent hypobaric hypoxia (CIHH) simulating altitude hypoxia increases the tolerance of myocardium to ischemia and hypoxia, and exerts a protective effect on the heart. 2,3 Our previous studies showed that CIHH promotes the recovery of damaged cardiac function, reduces the infarct size, and prevents arrhythmia during ischaemia/reperfusion. 2,4-6 In spite of multiple mechanisms and signalling pathways for the cardiac protective role of CIHH have been

show abstract

“…Myocardial sympathetic nerve function may be assessed by scintigraphy with iodine-123 MIBG (I-123 MIBG), a norepinephrine analog possessing identical mechanisms of storage, uptake, and release in neurons. Reduced I-123 MIBG uptake in the myocardium, regional defects, or a higher washout of I-123 MIBG 41,[82][83][84][85][86] correlates with myocardial sympathetic dysfunction, however, warrants further investigation before routine clinical use.…”

Section: Small Fiber Neuropathymentioning

confidence: 99%

The Burden of Neurosarcoidosis: Essential Approaches to Early Diagnosis and Treatment

Voortman

Stern

Saketkoo

et al. 2020

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Neurosarcoidosis (NS) is an often severe, destructive manifestation with a likely under-reported prevalence of 5 to 15% of sarcoidosis cases, and in its active phase demands timely treatment intervention. Clinical signs and symptoms of NS are variable and wide-ranging, depending on anatomical involvement. Cranial nerve dysfunction, cerebrospinal parenchymal disease, aseptic meningitis, and leptomeningeal disease are the most commonly recognized manifestations. However, non-organ-specific potentially neurologically driven symptoms, such as fatigue, cognitive dysfunction, and small fiber neuropathy, appear frequently.Heterogeneous clinical presentations and absence of any single conclusive test or biomarker render NS, and sarcoidosis itself, a challenging definitive diagnosis. Clinical suspicion of NS warrants a thorough systemic and neurologic evaluation hopefully resulting in supportive extraneural physical exam and/or tissue findings. Treatment targets the severity of the manifestation, with careful discernment of whether NS reflects active potentially reversible inflammatory granulomatous disease versus inactive postinflammatory damage whereby functional impairment is unlikely to be pharmacologically responsive. Non-organ-specific symptoms are poorly understood, challenging in deciphering reversibility and often identified too late to respond to conventional immunosuppressive/pharmacological treatment. Physical therapy, coping strategies, and stress reduction may benefit patients with all disease activity levels of NS.This publication provides an approach to screening, diagnosis, disease activity discernment, and pharmacological as well as nonpharmacological treatment interventions to reduce disability and protect health-related quality of life in NS.

show abstract

Cardiac autonomic innervation

Cited by 36 publications

References 115 publications

Risk Factors Associated with Cardiac Autonomic Modulation in Obese Individuals

Risk Factors Associated with Cardiac Autonomic Modulation in Obese Individuals

Effect of chronic intermittent hypobaric hypoxia on heart rate variability in conscious rats

The Burden of Neurosarcoidosis: Essential Approaches to Early Diagnosis and Treatment

Contact Info

Product

Resources

About