Cardiac autonomic neuropathy may play a role in pathogenesis of atherosclerosis in type 1 diabetes mellitus

Mala, Sarka; Potočková, Veronika; Hoskovcová, L; Piťhová, Pavlína; Brabec, Marek; Kulhankova, Jaroslava; Keil, Radan; Riedlbauchová, Lucie; Brož, Jan

doi:10.1016/j.diabres.2017.10.002

Cited by 15 publications

(20 citation statements)

References 22 publications

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“…CAN is a neglected microvascular complication which increases the risk of cardiac arrhythmias, of atherosclerosis progression, and of sudden death [20]. The first abnormality usually observed in the course of CAN is an impairment of parasympathetic function, resulting in an imbalance of the sympathetic/parasympathetic tone that is followed by sympathetic denervation [21].…”

Section: Discussionmentioning

confidence: 99%

Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes

Santos‐Bezerra

Filgueiras

Monteiro

et al. 2020

Mediators of Inflammation

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Background and Aims. Since hyperglycemia promotes inflammation by different pathways and inflammation participates in the development of chronic diabetes complications, we investigated the association between the leukotriene (LT) pathway and microvascular diabetes complications. Methods and Results. Quantitative polymerase chain reaction was employed to quantify the expression of ALOX5 (encodes 5-lipoxygenase), LTB4R (encodes one of the LTB4 receptors), and MYD88 in peripheral blood mononuclear cells from 164 type 1 diabetes (T1D) individuals presenting or not diabetes kidney disease, retinopathy, peripheral neuropathy, and cardiovascular autonomic neuropathy (CAN); 26 nondiabetic subjects were included as controls. LTB4 plasmatic concentrations were also evaluated. The expression of LTB4R was significantly higher in T1D individuals than in controls. T1D individuals with microvascular complications presented lower MYD88 mRNA expression when compared to those without microvascular complications. Higher LTB4 concentrations were found in individuals with CAN versus without CAN. The observation of two distinct subgroups of T1D individuals in the correlation analyses motivated us to evaluate the characteristics of each one of these groups separately. The group presenting higher expression of ALOX5 and of LTB4R also presented higher values of HbA1C, of fructosamine, and of plasmatic LTB4. Conclusion. In the diabetes setting, the LT pathway is not only activated by hyperglycemia but is also modulated by the status of the autonomic nervous system.

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Section: Discussionmentioning

confidence: 99%

Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes

Santos‐Bezerra

Filgueiras

Monteiro

et al. 2020

Mediators of Inflammation

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“…Also in type 2 diabetes, it has been reported that the cardiovascular autonomic response of patients with a reduced ABI is different compared to that of their counterparts showing increased ABI, suggesting that the autonomic nervous system, by regulating HR and vessel diameter, might contribute to both peripheral atherosclerosis and AS (27). Although it has been less studied than in patients with type 2 diabetes, the association between CAN and atherosclerosis has been reported in patients with type 1 diabetes too (12,28). Increased carotid intima thickness was recently related to CAN in individuals with type 1 diabetes (12).…”

Section: Discussionmentioning

confidence: 99%

“…Although it has been less studied than in patients with type 2 diabetes, the association between CAN and atherosclerosis has been reported in patients with type 1 diabetes too (12,28). Increased carotid intima thickness was recently related to CAN in individuals with type 1 diabetes (12). Furthermore, the combination of type 1 diabetes and CAN impacted negatively on carotid intima thickness even more than the sum of the ADVANCE ARTICLE: individual impacts of these traits (12).…”

Section: Discussionmentioning

confidence: 99%

“…Increased carotid intima thickness was recently related to CAN in individuals with type 1 diabetes (12). Furthermore, the combination of type 1 diabetes and CAN impacted negatively on carotid intima thickness even more than the sum of the ADVANCE ARTICLE: individual impacts of these traits (12). Similarly, the Coronary Artery Calcification in Type 1 Diabetes study (28) reported that an abnormal HR variability may be linked to the progression of coronary artery calcification, supporting that the presence of autonomic neuropathy contributes to the process of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between CAN and atherosclerosis is well-known (11)(12)(13). The autonomic nervous system regulates HR and vascular tone and its dysfunction may contribute to the development of atherosclerosis and AS in patients with diabetes mellitus (8).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of Cardiovascular Autonomic Dysfunction With Peripheral Arterial Stiffness in Patients With Type 1 Diabetes

Nattero‐Chávez

López

Díaz

et al. 2019

The Journal of Clinical Endocrinology &Amp; Metabolism

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Advance Articles are PDF versions of manuscripts that have been peer reviewed and accepted but not yet copyedited. The manuscripts are published online as soon as possible after acceptance and before the copyedited, typeset articles are published. They are posted "as is" (i.e., as submitted by the authors at the modification stage), and do not reflect editorial changes. No corrections/changes to the PDF manuscripts are accepted. Accordingly, there likely will be differences between the Advance Article manuscripts and the final, typeset articles. The manuscripts remain listed on the Advance Article page until the final, typeset articles are posted. At that point, the manuscripts are removed from the Advance Article page. DISCLAIMER: These manuscripts are provided "as is" without warranty of any kind, either express or particular purpose, or non-infringement. Changes will be made to these manuscripts before publication. Review and/or use or reliance on these materials is at the discretion and risk of the reader/user. In no event shall the Endocrine Society be liable for damages of any kind arising references to, products or publications do not imply endorsement of that product or publication.

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Quantification of lipoproteins by proton nuclear magnetic resonance spectroscopy (1H-NMRS) improves the prediction of cardiac autonomic dysfunction in patients with type 1 diabetes

Nattero-Chávez,

Insenser,

Amigó

et al. 2024

J Endocrinol Invest

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Cardiac autonomic neuropathy may play a role in pathogenesis of atherosclerosis in type 1 diabetes mellitus

Cited by 15 publications

References 22 publications

Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes

Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes

Association of Cardiovascular Autonomic Dysfunction With Peripheral Arterial Stiffness in Patients With Type 1 Diabetes

Quantification of lipoproteins by proton nuclear magnetic resonance spectroscopy (1H-NMRS) improves the prediction of cardiac autonomic dysfunction in patients with type 1 diabetes

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