Cardiac diastolic dysfunction predicts in-hospital mortality in acute ischemic stroke with atrial fibrillation

Tateishi, Yohei; Tsujino, Akira; Hamabe, Jumpei; Tsuneto, Akira; Maemura, Koji; Tasaki, Osamu; Horie, Nobutaka; Izumo, Tsuyoshi; Hayashi, Kentarō; Nagata, Izumi

doi:10.1016/j.jns.2014.07.011

Cited by 7 publications

(2 citation statements)

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“…NVAF is the unsynchronized contraction of the left atrium leading to the loss of mechanical function of the atrium, which causes blood to form eddies in the atrium, leading to thrombosis. [16][17][18] To date, the mechanism of NVAF remains unclear, but a large number of studies have shown that inflammatory reactions are closely related to the triggering and maintenance of atrial fibrillation. Inflammation can increase the risk of atrial fibrillation in various cardiovascular diseases such as coronary heart disease, heart failure, and hypertension and the anti-inflammatory effect of glucocorticoids can reduce the risk of recurrence of atrial fibrillation within 3 days after radiofrequency ablation.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Platelet-to-Lymphocyte Ratio Combined with CHA2DS2-VASc Score for Nonvalvular Atrial Fibrillation Induced Cardiogenic Cerebral Embolism

Fan,

Gao,

Wang

et al. 2023

JIR

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Aim To determine the predictive significance of the platelet-to-lymphocyte ratio (PLR) combined with the CHA 2 DS 2 -VAS c score for cardiogenic cerebral embolism (CCE) in patients with nonvalvular atrial fibrillation (NVAF). Methods A total of 553 patients with NVAF were included in this retrospective study. The general data, PLR, CHA 2 DS 2 -VAS c score and echocardiography indicators were compared. The risk factors for CCE and the predictive value of PLR and CHA 2 DS 2 -VAS c were analyzed. Stratified analysis was performed based on the cut-off value. Least absolute shrinkage and selection operator (LASSO) regression analysis was utilized to build a model. The relationship between risk score and different anticoagulants was evaluated. Results Multiple regression analysis showed hypertension (OR=3.95, 95% CI=2.12–7.35, p =1.40×10 −5 ), diabetes mellitus (OR=2.95, 95% CI=1.57–5.58, p =7.65×10 −4 ), PLR (OR=1.01, 95% CI=1.00–1.01, p <10 −6 ), creatinine level (OR=1.01, 95% CI=1.00–1.02, p =7.44×10 −3 ), left atrial diameter (LAD) (OR=1.90, 95% CI=1.13–3.19, p =1.51×10 −2 ), ejection fraction (EF) (OR=0.93, 95% CI=0.87–0.98, p =8.06×10 −3 ) and CHA 2 DS 2 -VAS c score (OR=3.79, 95% CI=2.95–4.85, p <10 −6 ) were independent risk factors for CCE. A one-way linear analysis also showed the above seven indexes were significantly correlated with CCE ( F =56.4, p <10 −6 ). The area under the receiver operating characteristic (ROC) curve of PLR and CHA 2 DS 2 -VAS c score was 0.760 (95% CI:0.721–0.800), and 0.855 (95% CI: 0.824–0.886), respectively. Pearson correlation analysis showed that PLR was correlated with CHA 2 DS 2 -VAS c score (r=0.331, p <10 −6 ). Stratified analysis indicated there was a positive correlation between different risk group ( p <10 −6 ). Using the LASSO model, a composite indicator displayed differential power for distinguishing CCE with an AUC value of 0.884 (95% CI: 0.857–0.911). Patient...

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Platelet-to-Lymphocyte Ratio Combined with CHA2DS2-VASc Score for Nonvalvular Atrial Fibrillation Induced Cardiogenic Cerebral Embolism

Fan,

Gao,

Wang

et al. 2023

JIR

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“…Daha önceki çalışmalarda AF hastalarında bozulmuş sol ventrikül diyastolik fonksiyonları ile artmış mortalite arasındaki ilişki bulunmuştur (17,18). Bu çalışmada da tekli ve çok değişkenli analizde diyastolik disfonksiyon AF hastalarında morbidite ve mortalite ile ilişkili bulunmuştur.…”

Section: Tartişma Ve Sonuçunclassified

Atriyal fibrilasyon hastalarında nabız basıncı indeksinin kardiyoembolik olaylar ve mortalite ile ilişkisi

Karadavut¹

2022

Anadolu Kliniği Tıp Bilimleri Dergisi

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Nabız basınç indeksi (NBİ), nabız basıncının (NB) sistolik kan basıncına oranı ile elde edilir. Arteriyel sertlik ve kardiyovasküler hastalıkların (KVH) değerlendirilmesinde NB ölçümlerine göre daha güvenilir ve daha objektif bilgi verir. Bilindiği üzere atriyal fibrilasyonda (AF) vasküler hastalık mevcudiyeti emboli riskini artırmaktadır. Bu çalışmada, KVH prediktörü olan NBİ değerlerini kullanarak AF hastalarında gelişen kardiyoembolik olaylar (KEO) ve/veya mortalite ile ilişkisini incelemeyi amaçladık. Yöntemler: Çalışma, Şubat 2019 ile Haziran 2020 arasında prospektif olarak 191 AF hastası alınarak yapıldı. Hastalar; inme, geçici iskemik atak, periferik emboli ve bunlara bağlı ölüm gerçekleşmeyen (Grup-1, n=156) ve gerçekleşen (Grup-2, n=35) şeklinde ikiye ayrıldı. Bulgular: Grup-2'nin NBİ değerleri Grup-1'e göre anlamlı derecede yüksek olarak tespit edildi (0,38±0,05 ve 0,41±0,04, p<0,001). Çoklu regresyon analizi sonrası NBİ AF hastalarında KEO açısından bağımsız öngörücü olarak bulundu (Olasılık oranı: 2,82 [%95 Güven Aralığı: 1,68-4,71], p<0,001). Ayrıca, yapılan ROC analizinde NBİ, NB'ye göre KEO tahmin etmede daha güçlü bir parametre olarak saptandı (sırasıyla, eğri altındaki alan [AUC]=0,734 ve AUC=0,661). Sonuç: AF hastalarında NBİ istenmeyen KEO ve buna bağlı ölümleri predikte etmek için kullanılabilecek non-invaziv ve ucuz bir fizik muayene bulgusudur.

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Subacute lesion volume as a potential prognostic biomarker for acute ischemic stroke after intravenous thrombolysis

Tateishi

Hamabe

Kanamoto

et al. 2016

Journal of the Neurological Sciences

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Cardiac diastolic dysfunction predicts in-hospital mortality in acute ischemic stroke with atrial fibrillation

Abstract: There is no grant support.

Cited by 7 publications

References 23 publications

Prognostic Value of Platelet-to-Lymphocyte Ratio Combined with CHA2DS2-VASc Score for Nonvalvular Atrial Fibrillation Induced Cardiogenic Cerebral Embolism

Prognostic Value of Platelet-to-Lymphocyte Ratio Combined with CHA2DS2-VASc Score for Nonvalvular Atrial Fibrillation Induced Cardiogenic Cerebral Embolism

Atriyal fibrilasyon hastalarında nabız basıncı indeksinin kardiyoembolik olaylar ve mortalite ile ilişkisi

Subacute lesion volume as a potential prognostic biomarker for acute ischemic stroke after intravenous thrombolysis

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