Cardiac effects of sertindole and quetiapine: Analysis of ECGs from a randomized double-blind study in patients with schizophrenia

Nielsen, Jimmi; Matz, Jørgen; Mittoux, Aurélia; Polcwiartek, Christoffer; Struijk, Johannes; Toft, Egon; Kanters, Jørgen K.; Graff, Claus

doi:10.1016/j.euroneuro.2014.12.005

Cited by 15 publications

(8 citation statements)

References 37 publications

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“…Only a few studies have explored the effects of psychotropics on TpTe (Nielsen et al, 2010(Nielsen et al, , 2015 and our study, for the first time, has extensively investigated the influence of antipsychotics and antidepressants on this parameter. Based on our results, the influence of antipsychotic and antidepressant medications on TpTe and QTd seemed restricted.…”

Section: Stepwise Linear Regression Tptementioning

confidence: 99%

Psychotropic drugs and ventricular repolarisation: The effects on QT interval, T-peak to T-end interval and QT dispersion

et al. 2017

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Section: Stepwise Linear Regression Tptementioning

confidence: 99%

Psychotropic drugs and ventricular repolarisation: The effects on QT interval, T-peak to T-end interval and QT dispersion

et al. 2017

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“…A mean change in QTc interval of −0.5 ± 17.9 ms was observed with quetiapine doses of 400–600 mg/day, but in the same study, 9.6% of patients had increases in QTc interval >20 ms in relation to baseline. 111 In other studies of psychiatric patients, quetiapine was associated with QTc prolongation of 1.3–5.7 ms in relation to baseline. 69 , 91 , 112 In healthy volunteers, quetiapine elicited mean QTc interval increases of 10.2 ms, with prolongation occurring in a dose-dependent manner.…”

Section: Antipsychoticsmentioning

confidence: 86%

“… 85 Many publications in our review did not report the formula used, and of those that did, Bazett’s was more common than Fridericia. In the study by Nielsen et al, 111 QT intervals were corrected with both Fridericia’s and Bazett’s formulas. Whereas the Fridericia formula showed a mean QTc change from baseline of −0.5 ms ± 17.9 ms with quetiapine, Bazett’s formula suggested that QTc interval increased by 7.9 ms ± 21.9 ms. Because of the tendency to overcorrect the QT interval, Bazett’s formula is not recommended by the American Heart Association for electrocardiogram calculations.…”

Section: Discussionmentioning

confidence: 99%

“… 87 Quetiapine was associated with a 4.81-ms (95% CI, 0.34–9.28) greater increase in QTc interval than was olanzapine, with similar QTc effects as for risperidone. 87 The results from individual studies were heterogeneous, with some studies 48 , 111 , 112 showing minimal or no effect on QTc interval and others 91 , 106 , 108 suggesting that quetiapine is associated with mean or median changes from baseline of −5 to +20 ms ( Table 3 ). A mean change in QTc interval of −0.5 ± 17.9 ms was observed with quetiapine doses of 400–600 mg/day, but in the same study, 9.6% of patients had increases in QTc interval >20 ms in relation to baseline.…”

Section: Antipsychoticsmentioning

confidence: 99%

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QTc Interval Prolongation with Therapies Used to Treat Patients with Parkinson’s Disease Psychosis: A Narrative Review

Torres‐Yaghi

Carwin

Carolan

et al. 2021

NDT

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In addition to the classic motor symptoms of Parkinson’s disease (PD), people with PD frequently experience nonmotor symptoms that can include autonomic dysfunction and neuropsychiatric symptoms such as PD psychosis (PDP). Common patient characteristics, including older age, use of multiple medications, and arrhythmias, are associated with increased risk of corrected QT interval (QTc) prolongation, and treatments for PDP (antipsychotics, dementia medications) may further increase this risk. This review evaluates how medications used to treat PDP affect QTc interval from literature indexed in the PubMed and Embase databases. Although not indicated for the treatment of psychosis, dementia therapies such as donepezil, rivastigmine, memantine, and galantamine are often used with or without antipsychotics and have minimal effects on QTc interval. Among the antipsychotics, data suggesting clinically meaningful QTc interval prolongation are limited. However, many antipsychotics have other safety concerns. Aripiprazole, olanzapine, and risperidone negatively affect motor function and are not recommended for PDP. Quetiapine is often sedating, can exacerbate underlying neurogenic orthostatic hypotension, and may prolong the QTc interval. Pimavanserin was approved by the US Food and Drug Administration (FDA) in 2016 and remains the only FDA-approved medication available to treat hallucinations and delusions associated with PDP. However, pimavanserin can increase QTc interval by approximately 5–8 ms. The potential for QTc prolongation should be considered in patients with symptomatic cardiac arrhythmias and those receiving QT-prolonging medications. In choosing a medication to treat PDP, expected efficacy must be balanced with potential safety concerns for individual patients.

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“…Frequently reported side effects of the drug include dizziness, dry mouth, nausea, constipation, lethargy, and increased appetite. Prolonged QT interval [ 3 ] and hematological effects [ 4 ] have been also described as unusual adverse reactions of quetiapine use. Still, quetiapine-associated hyponatremia is generally uncommon and only a few, relevant reports can be found in the literature.…”

Section: Introductionmentioning

confidence: 99%

Quetiapine-Induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Koufakis

2016

Case Reports in Psychiatry

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The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) can be induced by various conditions, including malignant neoplasms, infections, central nervous system disorders, and numerous drugs. We here report a case of a 65-year-old female patient, treated with quetiapine for schizophrenia, who presented with generalized tonic-clonic seizures and was finally diagnosed with quetiapine-induced SIADH. Quetiapine-associated hyponatremia is extremely uncommon and only a few, relevant reports can be found in the literature. This case underlines the fact that patients on antipsychotic medication and more specifically on quetiapine should be closely monitored and routinely tested for electrolyte disorders.

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Cardiac effects of sertindole and quetiapine: Analysis of ECGs from a randomized double-blind study in patients with schizophrenia

Cited by 15 publications

References 37 publications

Psychotropic drugs and ventricular repolarisation: The effects on QT interval, T-peak to T-end interval and QT dispersion

Psychotropic drugs and ventricular repolarisation: The effects on QT interval, T-peak to T-end interval and QT dispersion

QTc Interval Prolongation with Therapies Used to Treat Patients with Parkinson’s Disease Psychosis: A Narrative Review

Quetiapine-Induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone

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