Quetiapine-Induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Koufakis, Theocharis

doi:10.1155/2016/4803132

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Quetiapine has presented a positive re-challenge for causing hyponatremia in the elderly population [ 12 ]. Quetiapine has been associated with causing SIADH [ 17 ]. Atypical antipsychotics such as aripiprazole, quetiapine, clozapine cause hyponatremia due to their serotonin-mediated effects on central 5-HT2 and 5-HT1c receptors which lead to the release of ADH.…”

Section: Discussionmentioning

confidence: 99%

Identification of risk factors associated with hyponatremia in psychiatric patients: a case-control study

Powle

Shet

Mendonca

et al. 2022

Medicine and Pharmacy Reports

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Background and aims. Prompt recognition and optimal management of hyponatremia helps the physician devise a better treatment plan to prevent future complications in patients. Hence this study aims to identify the risk factors associated with hyponatremia in psychiatric patients. Methods. A case-control study was conducted among psychiatric inpatients in a tertiary care teaching hospital. Patients admitted from January 2013 to December 2017 were identified using ICD-10 code F01-F99. Patients with serum sodium levels < 135 mmol/L were considered to have hyponatremia and between 135-145 mmol/L as controls. Factors associated with hyponatremia were identified by multiple logistic regression, and the odds ratio (OR) was calculated. Results. Based on the inclusion and exclusion criteria, 264 cases of hyponatremia and 253 matching controls were included in the study. The mean age of patients with hyponatremia was 56.4 ± 16.8 years compared to 39.6 ± 13.9 years in controls, and 65.7% of them were males. Seizure disorder (OR = 3.14, p = 0.047), bipolar disorder (OR = 6.03, p = 0.001), depression (OR = 4.78, p = 0.0005), use of quetiapine (OR = 2.11, p = 0.007) and insulin (OR = 3.53, p = 0.038) were independent risk factors associated with development of hyponatremia. Conclusions. The chances of developing hyponatremia are increased in psychiatric patients with a seizure disorder, bipolar disorder, depression and using quetiapine or insulin. And they should be monitored carefully.

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Section: Discussionmentioning

confidence: 99%

Identification of risk factors associated with hyponatremia in psychiatric patients: a case-control study

Powle

Shet

Mendonca

et al. 2022

Medicine and Pharmacy Reports

View full text Add to dashboard Cite

show abstract

“…There are few cases of SIADH induced by quetiapine, something that could be related to underdiagnosis and underreporting of this situation. Nonetheless, some cases are collected where quetiapine, together with other factors such as advanced age and polytherapy, is involved in the development of hyponatremia [29][30][31].…”

Section: Quetiapinementioning

confidence: 99%

Hyponatremia and Psychotropic Drugs

Cortés¹,

Muñoz²

2019

Fluid and Electrolyte Disorders

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Given the widespread use of psychotropic drugs in the population, it's important to consider hyponatremia as an avoidable and reversible adverse effect and include the detection of high-risk subjects to establish safer medications, as well as early detection measures in routine clinical practice. Although hyponatremia has been especially associated with serotonergic antidepressants (SSRIs), there is also an elevated risk with tricyclics, duals and heterocyclic antidepressants, due to the different mechanisms of action at the renal tubular level and the release of ADH. Hyponatremia secondary to tricyclics with slow CYP2D6 metabolizers have higher plasma concentrations of antidepressants metabolized by CYP2D6. Hyponatremia secondary to SSRIs appears in the first week of treatment, it is "not dose-dependent" and normalization of natremia occurs between 2 and 20 days after stopping the medication. Bupropion, trazodone, mianserin, reboxetine and agomelatine are a safe alternative. Also antiepileptics have been related to hyponatremia. Both typical and atypical antipsychotics have been exposed to an increased risk of hyponatremia, even after adjusted factors such as age, sex and comorbidity. Other factors that favor the onset of hyponatremia act synergistically with psychotropic drugs, such as: advanced age, female sex, concomitant diuretic intake, low body weight and low sodium levels; NSAID, ACEIs, and warm.

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Schizophrenia and Related Psychoses

2021

The Maudsley Prescribing Guidelines in Psychiatry

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Despite disagreements about nomenclature, patients who develop schizophrenic or schizophrenialike symptoms in later life are often seen in clinical practice. Questions about the etiology of late-life psychotic disorders and about their similarities or differences from early-onset disorders remain unanswered. Neuroimaging techniques have been used to study patients with late onset of psychosis, and in substantial subgroups of patients (from 25% to 100% in various studies) compared with agematched control subjects, structural and functional abnormalities have been found. We review the literature on imaging in late-life schizophrenia and related psychotic disorders, and we present data from our own investigations of patients with these disorders. We discuss the potential usefulness of imaging evaluations in patients with late-onset disorders, and we offer suggestions for future investigations.

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Quetiapine-Induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Cited by 4 publications

References 11 publications

Identification of risk factors associated with hyponatremia in psychiatric patients: a case-control study

Identification of risk factors associated with hyponatremia in psychiatric patients: a case-control study

Hyponatremia and Psychotropic Drugs

Schizophrenia and Related Psychoses

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