Cardiac factors affecting the success of vardenafil in erectile dysfunction

Abstract

Background/aim: To evaluate the predictability of vardenafil success in patients with erectile dysfunction (ED) by using cardiological tests. Materials and methods:Patients diagnosed with ED who did not benefit from lifestyle changes (n = 68) were evaluated with an abridged 5-item version of the International Index of Erectile Function (IIEF-5). The pretreatment and posttreatment IIEF-5 scores were compared with pretreatment data obtained from cardiological examinations.Results: When pretreatment scores were compared with test parameters, mitral flow E/A ratio and tissue Doppler imaging (TDI) Eʹ/ Aʹ, exercise test duration, exercise capacity in MET, and percentage of maximum heart rate were found to be statistically significant. Furthermore, there was a significant negative correlation between mitral flow E/A ratio, TDI Eʹ/Aʹ, exercise test duration, exercise capacity in MET, and the difference in post-and pretreatment IIEF-5 scores. Conclusion:As a diastolic function indicator, TDI Eʹ/Aʹ positively correlates with pretreatment IIEF-5 scores and negatively correlates with the beneficial effect of vardenafil treatment. As a result, the cardiological status of the patient correlates with individual IIEF-5 scores, and it seems to be useful in predicting vardenafil success.

Can myocardial performance index predict early cardiac risks in erectile dysfunction?

“…Some authors have shown cardioprotective effects through regulation of endothelial dysfunction with continuous use of PDE 5 inhibitors, and it has also been shown that there may be positive hemodynamic effects in patients with HF [30]. A recent study showed that the E 0 /A 0 ratio as an indicator of diastolic functions was positively correlated with IIEF-5 scores before treatment and negatively correlated with the beneficial effect of vardenafil therapy [31]. However, these studies are short-lived.…”

Can Impaired Elasticity of Aorta Predict the Success of Vardenafil Treatment in Patients with Erectile Dysfunction?

“…Then, the patients were advised to use 10 mg vardenafil tablet before sexual intercourses for two months (one tablet for each sexual intercourse and use of at least 8 pills within this duration). The patients who used at least 8 ten-milligram vardenafil pills within this duration (maximum 12 pills) were reevaluated in respect to ED severity by the help of IIEF-5 at the end of two-month vardenafil treatment [ 4 ]. The difference between the pretreatment and posttreatment IIEF-5 values was accepted as ΔIIEF-5.…”

“…Until now, there has not been any guideline providing special indication for particular type of PDE5Is. Although there have been few studies searching predictors of PDE5I success, the physicians still do not have clinical parameters defining subjects who may benefit from PDE5Is [ 4 , 5 ].…”