Cardiac glycosides from shoot cultures of<i>Cryptostegia grandiflora</i>

El-Mawla, Ahmed Mohamed Ahmed Abd

doi:10.4103/0974-8490.60583

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…isolados das culturas de brotos de C. grandiflora (El-Mawla, 2010). Glicosídeos cardíacos, são compostos derivados de esteróides, esses por sua vez são derivados de triterpenos tetracíclicos.…”

Section: Cryptostegia Grandiflora (R Br)unclassified

Látex de plantas da família Apocynaceae: Uma revisão

Melo

Bonilla

Lucena

2021

RSD

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O látex vegetal é excretado pelo sistema de defesa da planta, em resposta a estresses. Em certos casos, o látex pode apresentar toxicidade, mas sua utilização é viável, pois seus componentes podem possuir atividades biológicas variadas, como: antibacteriana; antitumoral; antioxidante; antifúngica, anti-inflamatório; larvicida, dentre outras. Diferentes famílias botânicas produzem látex, uma das principais e mais abrangente é a Apocynaceae. Diante dessa abrangência, torna-se necessário a realização de estudos sobre a aplicabilidade do látex. Deste modo, o presente estudo teve como objetivo promover a busca por trabalhos científicos que descrevessem sobre o uso do látex das espécies: Calotropis procera (Aiton) W.T. Aiton; Cryptostegia grandiflora R. Br; Cryptostegia madagascariensis Bojer; Hancornia speciosa Gomes; Himatanthus drasticus Mart.; Allamanda blanchetti A. DC. por meio de uma revisão bibliográfica. Os trabalhos científicos foram selecionados sob critérios de exclusão e inclusão, nas bases de dados: “Periódicos CAPES”, “Science Direct”, “Scielo”, “PubMed”,”Google Scholar” e “SciFinder” sob um intervalo de tempo de 37 anos (1984-2021), sendo utilizados trabalhos nos idiomas: inglês e português. Os resultados apontam que o látex das espécies, podem atuar como: antimicrobiano, anti-helmíntico, antitumoral, anticâncer, anti-inflamatório, quimioterapêutico, larvicida, inseticida, dentre outras atividades. Conclui-se que, o látex vegetal é uma fonte promissora para a síntese de fármacos, repelentes, cosméticos, e pode estimular pesquisas que visem a extração consciente de recursos naturais.

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Section: Cryptostegia Grandiflora (R Br)unclassified

Látex de plantas da família Apocynaceae: Uma revisão

Melo

Bonilla

Lucena

2021

RSD

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“…Cardiac glycosides in shoot cultures of Cryptostegia grandiflora were identified when grown in modified MS medium [126]. The change in shoot segments and cardiac glycosides content was followed between day zero and day 12 at 2-day intervals.…”

Section: Cardiac Glycosides From Cryptostegiamentioning

confidence: 99%

Bioactive secondary metabolites produced in the author's laboratory by tissue culture techniques

El-Mawla¹

2014

Spatula DD

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Plant tissue culture techniques are used to maintain or grow plant cells, tissues or organs under sterile conditions on a nutrient culture medium of known composition. Plant tissue culture relies on the fact that many plant cells have the ability to regenerate a whole plant. Single cells, plant cells without cell walls (protoplasts), pieces of leaves, stems or roots can often be used to generate a new plant on culture media given the required nutrients and plant hormones. Cultured plant cells can be offered alternative sources over whole plant cultivation for the production of secondary metabolites. The explants, such as plant leaves, stems, roots, meristems etc. were used for cultivation and establishment of plant cell and tissue cultures. Unfortunately, most often plant cell cultures technologies not lead to an enhancement in secondary metabolites production. Therefore, Strain improvement, methods for the selection of high-producing cell lines, and medium optimizations must be considered to improve the production of secondary metabolites. Several types of cell culture methods are being used to produce bioactive compounds. Cell suspension cultures are preferred for production large amounts of cells for quantitative or qualitative analytical studies. This review refers to certain bioactive secondary metabolites produced in the author's laboratory by different tissue cultures techniques. ÖZETBitki dokusu kültür teknikleri bitki hücrelerini, dokularını veya organlarını bilinen bileşenlerde besleyici kültür ortamlarında steril şartlarda korumak ve beslemek için kullanılırlar. Bitki doku kültürleri, birçok bitki hücresinin tüm bir bitkiyi yeniden oluşturma yeteneğine sahip olması gerçeğine dayanır. Tek başlarına hücreler, hücre duvarı (protoplast) olmayan bitki hücreleri, yaprak parçaları, sap veya kökler gerekli besleyiciler ve bitki hormonları verilen kültür ortamlarında yeni bir bitki üretmek için sıklıkla kullanılabilmektedir. Kültüre edilmiş bitki hücreleri, sekonder metabolitlerin üretimi için tüm bitki yetiştirilmesi süresince alternatif bir kaynak olarak ortaya çıkabilir. Bitki yaprakları, kökler, saplar, filizler vb. gibi eksplantlar, bitki hücre ve doku kültürlerinin yetiştirilmesi ve kurulmasında kullanılmaktadır. Maalesef, çoğu zaman bitki hücre kültürü teknolojileri sekonder metabolit üretiminde bir artışa neden olmamaktadır. Bu yüzden suş geliştirme, yüksek üretilebilir hücre hatlarının seçimi için metotlar ve vasat optimizasyonu gibi yöntemler sekonder metabolit üretiminin geliştirilmesi için dikkate alınmalıdır. Biyoaktif bileşiklerin üretimi için birkaç tipte hücre kültürü kullanılmaktatır. Kantitatif ve kalitatif analitik çalışmalarda büyük miktarda hücre üretimi için hücre süspansiyon kültürleri tercih edilmektedir. Bu derleme, farklı doku kültür teknikleri sayesinde laboratuarlarda üretilen belirli biyoaktif sekonder metabolitlere değinmektedir. Anahtar kelimeler: Hücre süspansiyon kültürleri, filiz kültürleri, saçlı kök kültürleri, biyoaktif bileşikler.

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“…Since then this technique has been developed for the production of various secondary metabolites [16][17][18][19]. As a part of our continuing interest concerning the production of biologically active compounds by tissue culture [20][21][22], the present work describes optimum conditions to induce accumulation of hypoglycemic trigonelline and 4-hydroxyisoleucine in cell suspension cultures of Trigonella foenum graecum L.…”

Section: Introductionmentioning

confidence: 99%

Elicitation of Trigonelline and 4-Hydroxyisoleucine with Hypoglycemic Activity in Cell Suspension Cultures of Trigonella foenum graecum L

Mawla¹

2011

TOPROCJ

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Cell suspension cultures of Trigonella foenum graecum L. (fenugreek) were initiated from the cotyledon portions of sterile germinated seeds and maintained on MS medium supplemented with 2, 4-dichlorophenoxy acetic acid (2, 4-D) (1mg/l), kinetin (0.1 mg/l) and sucrose (5%). The changes in cell mass and both trigonelline and 4-hydroxyisoleucine content were followed between days zero and 12. The linear increase in fresh weight was found to be parallel to both trigonelline and 4-hydroxyisoleucine production. Cell suspension cultures treated with 100 μM methyl jasmonate (MJ) for 24 hours showed a noticeable increase in the level of trigonelline and 4-hydroxyisoleucine. The marked improvement in the histological and electron microscopically pictures of pancreas of STZ-diabetic rats fed with extract of cells treated with MJ is coincided with more effective and significant hypoglycemic activity than that for seeds extract. The extract of cultured cells treated with MJ lowered blood glucose from 284 ± 7.4 to 123 ± 8.1 units and increased the insulin level from 4.42 ± 0.23 μU/ml to a high level 8.33 ± 0.41 μU/ml.

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Cardiac glycosides from shoot cultures ofCryptostegia grandiflora

Cited by 5 publications

References 8 publications

Látex de plantas da família Apocynaceae: Uma revisão

Látex de plantas da família Apocynaceae: Uma revisão

Bioactive secondary metabolites produced in the author's laboratory by tissue culture techniques

Elicitation of Trigonelline and 4-Hydroxyisoleucine with Hypoglycemic Activity in Cell Suspension Cultures of Trigonella foenum graecum L

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