Cardiac involvement and cardiovascular risk factors in pediatric primary systemic vasculitides

Şener, Seher; Aydin, Ertan; Batu, Ezgi Deniz

doi:10.1007/s10067-022-06434-2

Cited by 2 publications

(1 citation statement)

References 101 publications

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“…Cardiac involvement is common in paediatric vasculitis like Kawasaki disease and Takayasu arteritis while it is rare in other systemic vasculitis like IgA vasculitis [ 63 ] .…”

Section: Vasculitismentioning

confidence: 99%

Childhood rheumatic diseases: bites not only the joint, but also the heart

Thomas

Aggarwal

2023

Clin Rheumatol

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Cardiovascular involvement in juvenile rheumatic diseases is the primary manifestation in paediatric vasculitis and a major organ manifestation in paediatric connective tissue diseases. Though coronary vasculitis is the prototypical manifestation of Kawasaki disease, it can also be seen in patients with polyarteritis nodosa. Pericarditis is the most common manifestation seen in juvenile rheumatic diseases like systemic onset JIA, and lupus. Cardiac tamponade, valvular insufficiency, aortic root dilatation and arrhythmias are seen rarely. Cardiac involvement is often recognized late in children. The development of cardiac disease in juvenile systemic sclerosis is associated with a poor outcome. In long term, childhood onset of rheumatic diseases predisposes to diastolic dysfunction and premature atherosclerosis during adulthood. Key Points • Pericarditis is the most common cardiac manifestation in SLE and can lead to tamponade. • Conduction defects are common in juvenile mixed connective tissue disease and systemic sclerosis. • Pulmonary hypertension is a significant contributor to mortality in juvenile systemic sclerosis. • In Kawasaki disease, early treatment can reduce risk of coronary artery aneurysms.

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“…Cardiac involvement is common in paediatric vasculitis like Kawasaki disease and Takayasu arteritis while it is rare in other systemic vasculitis like IgA vasculitis [ 63 ] .…”

Section: Vasculitismentioning

confidence: 99%

Childhood rheumatic diseases: bites not only the joint, but also the heart

Thomas

Aggarwal

2023

Clin Rheumatol

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Polyarteritis nodosa mimics Kawasaki disease

Alibrahim,

Mirza,

Khojah

2024

BMJ Case Rep

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Polyarteritis nodosa (PAN) is a rarely seen vasculitis that often affects small-sized and medium-sized arteries. PAN can present with diverse clinical features depending on the organs involved, including potential cardiac involvement. Typical cardiac manifestations of PAN in the paediatric age group include pericarditis, valvular heart disease and coronary artery aneurysms. In contrast to PAN, Kawasaki disease (KD) is often associated with coronary artery abnormalities. Herein, we report a case of a young boy presented with KD-like features, including a coronary artery aneurysm confirmed by an echocardiogram (ECHO) and eventually diagnosed as PAN. The patient was treated with steroids, methotrexate and tocilizumab with improvement of the symptoms. Repeated ECHO revealed the resolution of the coronary artery aneurysms. Our paper highlights a rare presentation of PAN mimicking KD presentation. Physicians should consider PAN in chronic or severe courses of KD or coronary artery aneurysms.

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Cardiac involvement and cardiovascular risk factors in pediatric primary systemic vasculitides

Cited by 2 publications

References 101 publications

Childhood rheumatic diseases: bites not only the joint, but also the heart

Childhood rheumatic diseases: bites not only the joint, but also the heart

Polyarteritis nodosa mimics Kawasaki disease

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