Cardiac involvement in Crohn’s disease: Echocardiographic study

Bragagni, Gianpaolo; Brogna, Raffaele; Franceschetti, Paola; Zoli, Giorgio

doi:10.1111/j.1440-1746.2006.04384.x

Cited by 17 publications

(10 citation statements)

References 60 publications

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“…4 Some further studies have also reported an increased frequency of MVP in systemic lupus erythematosus (SLE); 8,9 and recently in Crohn's disease. 10 All these findings imply that an autoimmune mechanism might be involved in the development of MVP. However, the pathogenesis of this disorder remains largely unknown.…”

Section: Introductionmentioning

confidence: 97%

Mitral valve prolapse in young healthy individuals. An early index of autoimmunity?

Evangelopoulos

Toumanidis

Sotou

et al. 2009

Lupus

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Mitral valve prolapse (MVP) is a benign valvular abnormality. However, an increased prevalence of MVP is reported in patients with systemic lupus erythematosus and autoimmune thyroid disease. Our aim was to evaluate whether the presence of MVP in healthy individuals might indicate a premature index of subclinical autoimmune disorder. A total of 75 individuals with MVP and 44 individuals without MVP were identified by echocardiography. Serum samples were examined for various organ and non-organ specific autoantibodies. In all, 35 of the 75 individuals with MVP had at least one autoantibody. ANA were detected in 17/75 in MVP(+) versus 1/44 in the MVP(-), (P < 0.05), and anti-ENA in 6/75 in the MVP(+) versus 0/44 in the control group, P = ns. In the MVP(+) group, thyroid autoantibodies, IgA and IgG RF were found at a statistically significant higher incidence, 16/75, 11/75 and 10/75 versus 1/44, 0/44 and 0/44 in the MVP(-)group, respectively (P < 0.05). The levels of IgG anticardiolipin antibodies were significantly higher in the MVP(+) group, P < 0.05. The presence of organ and non-organ specific autoantibodies in young healthy MVP(+) individuals insinuate the presence of subclinical autoimmunity and might suggest that autoimmune mechanisms might be involved in its pathogenesis. A follow-up of these individuals might elucidate whether MVP constitutes an early index of autoimmunity.

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Section: Introductionmentioning

confidence: 97%

Mitral valve prolapse in young healthy individuals. An early index of autoimmunity?

Evangelopoulos

Toumanidis

Sotou

et al. 2009

Lupus

View full text Add to dashboard Cite

show abstract

“…As a consequence, we hypothesize that both abnormal collagen deposition and endothelial dysfunction could be responsible for MVP. Some studies report an increased prevalence of MVP in connective tissue disorders [24] and in autoimmune disorders such as systemic lupus erythematosus [25] and Crohn's disease [26]. Thus, such findings may also suggest an autoimmune mechanism to be involved in the development of MVP.…”

Section: Discussionmentioning

confidence: 95%

Echocardiographic evaluation in subjects with α₁‐Antitrypsin deficiency

Vizzardi

Corda

Sciatti

et al. 2015

Eur J Clin Investigation

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“…Left ventricular EF was found to be depressed; left atrial enlargement and increased interventricular septum thickness were revealed in adult inflammatory bowel disease patients in previous studies. 31,32 Left ventricular end-systolic dimension has a prognostic importance on reverse remodelling in patients diagnosed with heart failure. 33 Left ventricular myocardial performance parameters were found to be depressed by speckle tracking echocardiography in inflammatory bowel disease.…”

Section: Discussionmentioning

confidence: 99%

Cardiac functions and aortic elasticity in children with inflammatory bowel disease: effect of age at disease onset

Erolu

Polat

2020

Cardiol Young

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Aim:Childhood onset inflammatory bowel disease is more aggressive and has rapidly progressive clinical course than adult inflammatory bowel disease. Early-onset inflammatory bowel disease has more severe clinical progression as a subspecialised group of monogenic inflammatory bowel disease. We studied cardiac functions and aortic elasticity in children with early- and late-onset inflammatory bowel disease in remission period.Methods:Thirty-three paediatric patients were divided into subgroups according to age of disease onset (<10 and >10 years of age). Twenty-five healthy children were admitted as control group. M-Mode echocardiography and pulsed wave Doppler echocardiography were performed. Strain, distensibility, stiffness index of ascending, and abdominal aorta were evaluated.Results:Interventricular septum (mm) and left ventricular end-systolic diameter were higher (6.9 ± 1.2, 26.2 ± 4.6) in early-onset inflammatory bowel disease patients than control patients (6.1 ± 1.27, 22.7 ± 4.12) (p = 0.050, p = 0.050). Mitral E/E′ ratio and myocardial performance index were increased in inflammatory bowel disease and early-onset inflammatory bowel disease groups than control group (p = 0.046, p = 0.04; p = 0.023, p = 0.033). Diastolic functions were found to be impaired in inflammatory bowel disease and early-onset inflammatory bowel disease groups according to control group, while there was no difference between late-onset inflammatory bowel disease and control groups in terms of diastolic functions. Mitral E/A ratio was lower in inflammatory bowel disease patients and early-onset inflammatory bowel disease patients (1.46 ± 0.32, 1.4 ± 0.21) than control patients (1.70 ± 0.27) (p = 0.013, p = 0.004). Aortic elasticity did not differ between groups.Conclusion:Chronic low-grade inflammation has effects on left ventricular diameters and diastolic function in remission period. Aortic elasticity is not affected in our study groups.

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Cardiac involvement in Crohn’s disease: Echocardiographic study

Cited by 17 publications

References 60 publications

Mitral valve prolapse in young healthy individuals. An early index of autoimmunity?

Mitral valve prolapse in young healthy individuals. An early index of autoimmunity?

Echocardiographic evaluation in subjects with α₁‐Antitrypsin deficiency

Cardiac functions and aortic elasticity in children with inflammatory bowel disease: effect of age at disease onset

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Cardiac involvement in Crohn’s disease: Echocardiographic study

Cited by 17 publications

References 60 publications

Mitral valve prolapse in young healthy individuals. An early index of autoimmunity?

Mitral valve prolapse in young healthy individuals. An early index of autoimmunity?

Echocardiographic evaluation in subjects with α1‐Antitrypsin deficiency

Cardiac functions and aortic elasticity in children with inflammatory bowel disease: effect of age at disease onset

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Echocardiographic evaluation in subjects with α₁‐Antitrypsin deficiency